Sigma-1 Receptor Specific Biological Functions, Protective Role, and Therapeutic Potential in Cardiovascular Diseases

Cardiovascular Toxicology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 12, 2025

Язык: Английский

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Afobazole alleviates streptozotocin-induced diabetic nephropathy in rats via hypoglycemic, antioxidant, anti-inflammatory, and anti-apoptotic properties: Role of the S1R/Nrf2 antioxidant axis

Life Sciences, Год журнала: 2025, Номер 363, С. 123410 - 123410

Опубликована: Янв. 20, 2025

Язык: Английский

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Lactobacillus rhamnosus GG Ameliorates Atherosclerosis via Suppression of Oxidative Stress and Inflammation by Reshaping the Gut Microbiota

Biochemical and Biophysical Research Communications, Год журнала: 2025, Номер 751, С. 151417 - 151417

Опубликована: Фев. 5, 2025

Язык: Английский

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Activation of sigma 1 receptor attenuates doxorubicin-induced cardiotoxicity by alleviating oxidative stress, mitochondria dysfunction, ER stress-related apoptosis, and autophagy impairment

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 310, С. 143549 - 143549

Опубликована: Апрель 26, 2025

Язык: Английский

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The use of amino acids and their derivates to mitigate against pesticide-induced toxicity

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 276, С. 116340 - 116340

Опубликована: Апрель 17, 2024

Exposure to pesticides induces oxidative stress and deleterious effects on various tissues in non-target organisms. Numerous models investigating pesticide exposure have demonstrated metabolic disturbances such as imbalances amino acid levels within the organism. One potentially effective strategy mitigate toxicity involves dietary intervention by supplementing exogenous acids their derivates augment body's antioxidant capacity pesticide-induced harm, whose mechanism including bolstering glutathione synthesis, regulating arginine-NO metabolism, mitochondria-related stress, open of ion channels, well enhancing intestinal microecology. Enhancing synthesis through supplementation substrates N-acetylcysteine glycine is regarded a potent achieve this. Selection appropriate or for supplementation, determining an dosage, are utmost importance mitigation harm. More experimentation required that large population samples validate efficacy strategies, determine long-term low-dose exposure. This review provides insights guide future research aimed at preventing alleviating derivates.

Язык: Английский

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Targeting the sigma-1 receptor with pridopidine induces functional neurorestoration in spinal cord ischemia-reperfusion injury

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 12, 2025

Язык: Английский

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Nrf2 and its signaling pathways in sepsis and its complications: A comprehensive review of research progress

Medicine, Год журнала: 2025, Номер 104(16), С. e42132 - e42132

Опубликована: Апрель 18, 2025

Sepsis is a life-threatening condition characterized by organ dysfunction resulting from dysregulated host immune response to infection. It associated with high incidence, intricate pathophysiological mechanisms, and rapidly progressive severity, rendering it leading cause of mortality among patients in intensive care units. The Nuclear Factor Erythroid 2-Related 2 (Nrf2) transcription factor pivotal for maintaining cellular redox homeostasis regulating the expression antioxidant cytoprotective genes. Emerging evidence suggests that activation Nrf2 signaling pathway attenuates sepsis-induced inflammatory responses, oxidative stress, dysfunction, thereby improving clinical outcomes. These findings underscore potential as therapeutic target, offering promising avenue development novel interventions aimed at mitigating complications prognosis sepsis.

Язык: Английский

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Chaperones vs. oxidative stress in the pathobiology of ischemic stroke

Frontiers in Molecular Neuroscience, Год журнала: 2024, Номер 17

Опубликована: Дек. 11, 2024

As many proteins prioritize functionality over constancy of structure, a proteome is the shortest stave in Liebig's barrel cell sustainability. In this regard, both prokaryotes and eukaryotes possess abundant machinery supporting quality healthy stressful conditions. This machinery, namely chaperones, assists folding, refolding, utilization client proteins. The functions chaperones are especially important for brain cells, which highly sophisticated terms structural functional organization. Molecular known to exert beneficial effects diseases including one most threatening widespread pathologies, ischemic stroke. However, whether how they antioxidant defense stroke remains unclear. Herein, we discuss shown fight oxidative stress mechanisms their action. stroke, during intense production free radicals, molecular preserve by interacting with oxidized proteins, regulating imbalanced mitochondrial function, directly fighting stress. For instance, cells recruit Hsp60 Hsp70 provide proper folding newly synthesized proteins-these factors required early response refold damaged polypeptides. Additionally, upregulates some dedicated pathways such as FOXO3 signaling. Small HSPs decrease via attenuation function through involvement regulation Nrf- (Hsp22), Akt Hippo (Hsp27) signaling well mitophagy (Hsp27, Hsp22). A similar has also been proposed Sigma-1 receptor, contributing function. Some can prevent excessive formation reactive oxygen species whereas Hsp90 suggested be responsible pro-oxidant Finally, heat-resistant obscure (Hero) able shield thus preventing possible oxidation.

Язык: Английский

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Sigma-1 receptor signaling: A potential therapeutic approach for ischemic stroke

Journal of Cerebral Blood Flow & Metabolism, Год журнала: 2024, Номер unknown

Опубликована: Сен. 9, 2024

Strokes constitute over 50% of all neurological diseases, standing as the foremost cause physical and mental disability. Currently, there are no widely accepted gold standard treatments for ischemic strokes beyond intravenous thrombolysis mechanical thrombectomy applied during acute therapeutic window. Therefore, need novel targeting crucial signaling mediators involved in stroke is utmost importance. The sigma-1 receptor (S1R), a molecular chaperone located at mitochondria-associated endoplasmic reticulum membranes (MAM), has exhibited neuroprotective effects when modulated by synthetic endogenous agents across various cerebrovascular diseases. In this review, we describe emerging role S1R agonists antagonists regulating blood-brain barrier (BBB) dysfunction, neuroinflammation, neurocognitive impairment following stroke.

Язык: Английский

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CSN6 aggravates inflammation and Myocardial injury in macrophage of sepsis model by MIF

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Июнь 3, 2024

Sepsis, one of the leading causes death in critically ill patients, is characterized by multiple organ dysfunction caused dysregulated immune response to infection. Hence, we investigated that effects CSN6 sepsis and underlying mechanism. RAW264.7 cell inducted with lipopolysaccharide (LPS) adenosine triphosphate (ATP). protein expression macrophage vitro model was increased. We collected 10 patients single analysis expression. aggravated inflammation sepsis. ferroptosis mitochondrial damage induced MIF inhibitor reduced on at 11-ARG, 21-ARG, 31-LEU, 32-ASP linked 280-ASN, 366-SER.In conclusion, aggravates myocardial injury signaling, suggesting targeting this mechanism may be a feasible strategy anti-inflammation for or sepsis-induced injury.

Язык: Английский

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