Current Treatments, Emerging Therapeutics, and Natural Remedies for Inflammatory Bowel Disease

Molecules, Год журнала: 2024, Номер 29(16), С. 3954 - 3954

Опубликована: Авг. 21, 2024

Inflammatory bowel disease (IBD) is a chronic, lifelong disorder characterized by inflammation of the gastrointestinal (GI) tract. The exact etiology IBD remains incompletely understood due to its multifaceted nature, which includes genetic predisposition, environmental factors, and host immune response dysfunction. Currently, there no cure for IBD. This review discusses available treatment options challenges they present. Importantly, we examine emerging therapeutics, such as biologics immunomodulators, that offer targeted strategies While many patients do not respond adequately most biologics, recent clinical trials combining with small-molecule drugs (SMDs) have provided new insights into improving landscape. Furthermore, numerous novel specific therapeutic targets been identified. high cost poses significant barrier treatment, but this challenge may be alleviated development more affordable biosimilars. Additionally, point-of-care protein biomarkers from serum plasma are showing potential enhancing precision diagnosis prognosis. Several natural products (NPs), including crude extracts, small molecules, peptides, demonstrated promising anti-inflammatory activity in high-throughput screening (HTS) systems advanced artificial intelligence (AI)-assisted platforms, molecular docking ADMET prediction. These platforms advancing search alternative therapies derived sources, potentially leading safer fewer side effects.

Язык: Английский

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Rutin Ameliorates Inflammation and Oxidative Stress in Ulcerative Colitis by Inhibiting NLRP3 Inflammasome Signaling Pathway

Cell Biochemistry and Biophysics, Год журнала: 2024, Номер 82(4), С. 3715 - 3726

Опубликована: Авг. 13, 2024

Ulcerative colitis (UC) is an idiopathic inflammatory disease. We intend to explore the mechanism of Rutin in therapy UC. Disease activity index (DAI) and hematoxylin-eosin staining were employed assess therapeutic effect on dextran sulfate sodium-stimulated mice. The proliferation was detected by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide assay. Oxidative stress (OS) assessed measuring reactive oxygen species (ROS), malondialdehyde (MDA), superoxide dismutase (SOD). Inflammatory factors using enzyme-linked immunosorbent assay immunofluorescence staining. mRNA protein expressions real-time quantitative polymerase chain reaction immunoblotting decreased DAI scores ameliorated pathological damage UC mice with levels factors. recovered inhibited fetal human colon cells caused lipopolysaccharide. OS reducing ROS MDA, while enhancing SOD LPS-induced cells. NLRP3 inflammasome cell model. Silencing enhanced inhibitory lipopolysaccharide-induced Conversely, overexpression reversed restraining role OS. ameliorates inhibiting inflammation through suppressing inflammasome.

Язык: Английский

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Cyclic adenosine 3’, 5’-monophosphate (cAMP) signaling is a crucial therapeutic target for ulcerative colitis

Life Sciences, Год журнала: 2024, Номер 353, С. 122901 - 122901

Опубликована: Июль 10, 2024

Язык: Английский

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Genome-Wide Identification of Cell Type-Specific Susceptibility Genes for SLE Through the Analysis of RNA Modification-Associated SNPs

Immunological Investigations, Год журнала: 2024, Номер unknown, С. 1 - 15

Опубликована: Сен. 4, 2024

This study aimed to elucidate the functional genes associated with systemic lupus erythematosus (SLE) in various cell types through utilization of RNAm-SNPs.

Язык: Английский

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