Neutrophil diversity and function in health and disease

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Дек. 5, 2024

Abstract Neutrophils, the most abundant type of granulocyte, are widely recognized as one pivotal contributors to acute inflammatory response. Initially, neutrophils were considered mobile infantry innate immune system, tasked with immediate response invading pathogens. However, recent studies have demonstrated that versatile cells, capable regulating various biological processes and impacting both human health disease. Cytokines other active mediators regulate functional activity by activating multiple receptors on these thereby initiating downstream signal transduction pathways. Dysfunctions in disruptions neutrophil homeostasis been implicated pathogenesis numerous diseases, including cancer disorders, often due aberrant intracellular signaling. This review provides a comprehensive synthesis functions, integrating advancements this field. Moreover, it examines roles signaling pathways involved regulation activity. The pathophysiology diseases emerging therapeutic approaches targeting them also elaborated. addresses current limitations within field research, highlighting critical gaps knowledge warrant further investigation. In summary, seeks establish multidimensional model regulation, providing new perspectives for potential clinical applications research.

Язык: Английский

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Therapeutic Targeting of the Janus Kinase/Signal Transducer and Activator of Transcription Pathway in Cutaneous T-Cell Lymphoma

Cancers, Год журнала: 2025, Номер 17(4), С. 568 - 568

Опубликована: Фев. 7, 2025

Background/Objectives: Cutaneous T-cell lymphoma (CTCL) is a rare group of non-Hodgkin lymphomas characterized by the clonal expansion malignant T cells. While current treatments can alleviate symptoms and significant progress has been made in treating leukemic CTCL, definitive cure remains elusive. Dysregulation Janus kinase/signal transducer activator transcription (JAK/STAT) signaling pathway key driver CTCL pathogenesis. As result, therapeutic strategies targeting JAK/STAT have gained momentum, with increasing use JAK inhibitors other agents that effectively suppress this pathway. These immune-modulating therapies broad effects on physiological processes, inflammation, pathological changes associated both inflammatory diseases cancers. Several inhibitors, originally FDA-approved for conditions, are now being investigated cancer treatment. Methods: In paper, brief review literature dysregulation provided, highlighting clinical preclinical studies involving target Results: Specifically, we focus six currently under investigation-golidocitinib, ruxolitinib, cerdulatinib, tofacitinib, upadacitinib, abrocitinib. Additionally, discuss explore mechanisms underlying inhibition CTCL. Furthermore, reported cases which relapsed or emerged following inhibitor Conclusions: Collectively, these findings support potential utility However, further research needed to evaluate safety risks, minimize adverse effects, optimize strategies.

Язык: Английский

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Rewiring the T cell-suppressive cytokine landscape of the tumor microenvironment: a new frontier for precision anti-cancer therapy

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Авг. 30, 2024

T lymphocytes that infiltrate the tumor microenvironment (TME) often fail to function as effective anti-cancer agents. Within TME, cell-to-cell inhibitory interactions play significant roles in dampening their anti-tumor activities. Recent studies have revealed soluble factors released TME by immune and non-immune cells, well cells themselves, contribute exacerbation of cell exhaustion. Our understanding cytokine landscape interrelationships, impact on cancer development is still at its early stages. In this review, we aim shed light Interleukin (IL) -6, IL-9, IL-10, a small group JAK/STAT signaling-dependent cytokines harboring cell-suppressive effects summarize mechanisms action. Additionally, will explore how advancements scientific research can help us overcoming obstacles posed suppress tumors, with ultimate objective stimulating further investigations for novel therapeutic strategies counteract tumor-promoting

Язык: Английский

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Targeting the JAK-STAT pathway in colorectal cancer: mechanisms, clinical implications, and therapeutic potential

Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12

Опубликована: Ноя. 26, 2024

Colorectal cancer (CRC) remains one of the most prevalent and fatal malignancies worldwide, consistently ranking among top three in terms incidence mortality. Despite notable advancements early detection therapeutic interventions, survival outcomes for advanced-stage CRC are still dismal, largely due to issues such as drug resistance metastasis. Recent research has increasingly implicated JAK-STAT signaling pathway a pivotal contributor pathogenesis. This evolutionarily conserved plays key role transmitting extracellular signals nucleus, thereby modulating gene expression involved numerous fundamental biological processes. In CRC, dysregulation is frequently observed strongly associated with tumor progression, including processes cellular proliferation, apoptosis, metastasis, immune evasion, sustenance stem cells. Given its integral advancement, gained recognition viable target. Extensive evidence from preclinical clinical models supports efficacy safety targeting components pathway, presenting new possibilities patients particularly addressing enhancing treatment outcomes. review offers detailed exploration focusing on regulatory mechanisms CRC-related malignancies. Moreover, it examines association between protein expression, features, prognosis, potential management.

Язык: Английский

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Analysis of the potential biological significance of glycosylation in triple-negative breast cancer on patient prognosis

American Journal of Translational Research, Год журнала: 2024, Номер 16(6), С. 2212 - 2232

Опубликована: Янв. 1, 2024

Breast cancer is the most common malignancy in women, with its prognosis varying greatly according to subtype. Triple-negative breast (TNBC) has worst among all subtypes. Glycosylation a critical factor influencing of patients TNBC. Our aim develop tumor model by analyzing genes related glycosylation predict patient outcomes.

Язык: Английский

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