The imidazoline I2 receptor agonist 2-BFI enhances cytotoxic activity of hydroxychloroquine by modulating oxidative stress , energy-related metabolism and autophagic influx in human colorectal adenocarcinoma cell lines

European Journal of Pharmacology, Год журнала: 2025, Номер unknown, С. 177590 - 177590

Опубликована: Апрель 1, 2025

Язык: Английский

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The Role of Proteomics and Genomics in the Development of Colorectal Cancer Diagnostic Tools and Potential New Treatments

ACS Pharmacology & Translational Science, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

Язык: Английский

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RNA-binding proteins and autophagy in lung cancer: mechanistic insights and therapeutic perspectives

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Апрель 24, 2025

Lung cancer remains a leading cause of cancer-related mortality worldwide. Its progression is intricately associated with the dynamic regulation autophagy and RNA-binding proteins (RBPs), which play crucial roles in mRNA stability, alternative splicing, cellular stress responses. This review aims to systematically analyze mechanisms through RBPs contribute lung explore potential therapeutic strategies targeting these pathways. We reviewed recent studies on molecular by regulate tumor proliferation, metabolic adaptation, their interaction autophagy. The also examines dual cancer, highlighting its context-dependent effects cell survival death. interactions regulatory networks between involve multiple levels regulation. can directly influence processes act as microRNA (miRNA) sponges stability. modulation affects expression autophagy-related genes (ATGs) autophagosome formation. Additionally, participate complex non-coding RNAs (ncRNAs), including long (lncRNAs), circular (circRNAs), other proteins. proposes innovative that combine RBP-targeting approaches (e.g., small molecule inhibitors, CRISPR gene editing) modulators mTOR chloroquine) enhance treatment efficacy. Nanoparticle drug delivery systems epigenetic offer further opportunities for targeted interventions. lays theoretical foundation advancing research provides novel insights into synergistic therapies target both improve outcomes cancer.

Язык: Английский

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The dawn of a new Era: mRNA vaccines in colorectal cancer immunotherapy

International Immunopharmacology, Год журнала: 2024, Номер 132, С. 112037 - 112037

Опубликована: Апрель 9, 2024

Язык: Английский

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Synthesis and Anti-Cancer Investigations of Copper(II) Complexes Based on Adenine

Journal of Molecular Structure, Год журнала: 2024, Номер 1315, С. 138836 - 138836

Опубликована: Июнь 1, 2024

Язык: Английский

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LINC00513 promotes colorectal cancer malignant progression by binding with IGF2BP1 to enhance the stability of connective tissue growth factor mRNA

Epigenomics, Год журнала: 2024, Номер 16(14), С. 985 - 998

Опубликована: Июль 17, 2024

Aim: This study aimed to investigate the role of LINC00513 in colorectal cancer (CRC) progression. Materials & methods: Cell proliferation was evaluated using Counting Kit-8. migration detected with transwell assay. RNA pull-down applied for verifying interactions between LINC00513, IGF2BP1 and connective tissue growth factor (CTGF). Results: CTGF levels were upregulated CRC. Knockdown significantly inhibited malignant behavior CRC cells. increased mRNA stability by binding IGF2BP1. Furthermore, overexpression or reversed inhibitory effect shRNA on Conclusion: promoted cell behaviors through IGF2BP1/CTGF.

Язык: Английский

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Identification of RNA-binding protein RBMS3 as a potential biomarker for immunotherapy in bladder cancer

Cancer Biomarkers, Год журнала: 2024, Номер unknown, С. 1 - 17

Опубликована: Авг. 4, 2024

RNA-binding protein (RBP) plays pivotal roles in the malignant progression of cancer by regulating gene expression. In this paper, we aimed to develop RBP-based prognostic signature and identify critical hub RBPs bladder (BLCA). Firstly, a risk model based on differentially expressed RBP gens (DERBPs) between normal tumor tissues was successfully established, which can predict stromal score drug sensitivity. Then two another models miRNA-correlated or lncRNA-correlated were also RBMS3 identified as overlapping three models. Data from multiple bioinformatics databases revealed that an independent factor for overall survival (OS), associated with immunosuppressive microenvironment (TME) BLCA. Further, Single-cell RNA-Seq (scRNA-Seq) data human altas (HPA) database showed expression (both mRNA protein) up-regulated BLCA cells. Finally, shown be worse response immunotherapy. Overall, is key TME remodeling function may serve target

Язык: Английский

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Effect of colorectal cancer stem cells on the development and metastasis of colorectal cancer

World Journal of Gastrointestinal Oncology, Год журнала: 2024, Номер 16(11), С. 4354 - 4368

Опубликована: Окт. 25, 2024

The relevant mechanism of tumor-associated macrophages (TAMs) in the treatment colorectal cancer patients with immune checkpoint inhibitors (ICIs) is discussed, and application prospects TAMs reversing tolerance ICIs are discussed to provide a reference for related studies. As class drugs widely used clinical tumor immunotherapy, can act on regulatory molecules cells that play an inhibitory role - checkpoints kill tumors form response by activating variety system. sensitivity different types ICI varies greatly. phenotype function microenvironment closely efficacy ICIs. regulate phenotypic TAMs, also affect therapy. important resistance, making full use this target as therapeutic strategy expected improve immunotherapy prognosis cancer.

Язык: Английский

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RNA binding protein RBM22 suppresses non-small cell lung cancer tumorigenesis by stabilizing LATS1 mRNA

Journal of Molecular Histology, Год журнала: 2024, Номер 56(1)

Опубликована: Ноя. 29, 2024

Язык: Английский

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