Cordycepin ameliorates autoimmunity by promoting STING degradation via autophagy pathway

British Journal of Pharmacology, Год журнала: 2024, Номер unknown

Опубликована: Дек. 15, 2024

Stimulator of interferon response cGAMP interactor 1 (STING), a central hub protein cyclic GMP-AMP synthase (cGAS)-STING signalling pathway, has crucial role in regulating type I interferons (IFNs) production and response. Recent studies indicate that excessive activation STING is strongly associated with autoimmune diseases, including systemic lupus erythematosus (SLE). Searching immunomodulators negatively regulate might greatly contribute to the suppression autoimmunity.

Язык: Английский

Novel Azepino[4,5-b]indolone as cGAS Inhibitors for Treating Immune-Mediated Diseases

ACS Medicinal Chemistry Letters, Год журнала: 2024, Номер 15(9), С. 1417 - 1418

Опубликована: Авг. 3, 2024

Provided herein are novel azepino[4,5-

Язык: Английский