Inflammatory bowel disease and neuropsychiatric disorders: Mechanisms and emerging therapeutics targeting the microbiota-gut-brain axis

Pharmacology & Therapeutics, Год журнала: 2025, Номер unknown, С. 108831 - 108831

Опубликована: Фев. 1, 2025

Язык: Английский

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Interaction between serum inflammatory cytokines and brain-derived neurotrophic factor in cognitive function among first-episode schizophrenia patients

World Journal of Psychiatry, Год журнала: 2024, Номер 14(12), С. 1804 - 1814

Опубликована: Ноя. 27, 2024

BACKGROUND The pathogenesis of cognitive impairment in schizophrenia (SCZ) remains unclear. Accumulating studies showed that inflammatory-immune dysregulation and altered brain derived neurotrophic factor (BDNF) levels play a crucial role the psychopathology SCZ. However, their association with dysfunction first-episode SCZ patients has not been thoroughly investigated. AIM To explore interaction effects between function inflammatory cytokines BDNF METHODS current study is cross-sectional case-control investigation recruited 84 (SCZ group) 80 healthy controls (HCs at Huzhou Third Municipal Hospital August 2021 September 2023. ELISA was employed to measure serum interleukin (IL)-1β, IL-4, IL-6, IL-10, BDNF. Chinese brief test (C-BCT) positive negative syndrome scales were measured severity psychiatric symptoms. RESULTS Compared HC group, group exhibited elevated IL-1β IL-6 levels, decreased reduced C-BCT scores (all P < 0.001). In SCZ, negatively correlated (r = -0.324, 0.05). Information processing speed -0.315, 0.05) positively 0.290, 0.05); attention, working memory, comprehensive ability, executive Multiple regression analysis influenced dimensions (β -0.218 -0.327, all attention ability by -0.199 -0.261, ; 0.209, . CONCLUSION Our findings suggested interrelationships immune deficiency might underlie pathological mechanisms impairments patients.

Язык: Английский

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Investigation of the Protective Effects of Aripiprazole on Methylphenidate-induced Neurotoxicity in Rats

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 29, 2025

Язык: Английский

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Zhumeria majdae essential oil attenuates TNBS-induced colitis in rats by regulating inflammatory and apoptotic pathways

Inflammopharmacology, Год журнала: 2024, Номер unknown

Опубликована: Сен. 23, 2024

Язык: Английский

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Peripheral blood complement factors C2 and C3 as biomarkers of clinical efficacy in patients with first-episode schizophrenia after aripiprazole treatment

BMC Psychiatry, Год журнала: 2024, Номер 24(1)

Опубликована: Дек. 31, 2024

Язык: Английский

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