Salvinorin A ameliorates pilocarpine-induced seizures by regulating hippocampal microglia polarization

Journal of Ethnopharmacology, Год журнала: 2024, Номер 335, С. 118697 - 118697

Опубликована: Авг. 16, 2024

Язык: Английский

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Glycyrrhizin as a potential disease-modifying therapy for epilepsy: insights into targeting pyroptosis to exert neuroprotective and anticonvulsant effects

Frontiers in Pharmacology, Год журнала: 2025, Номер 15

Опубликована: Янв. 6, 2025

For patients with epilepsy, antiseizure medication remains the primary treatment; however, it is ineffective in approximately 30% of cases. These experience progressive neuronal damage and poor outcomes. Therefore, there an urgent need for disease-modifying therapy (DMT) that targets pathogenesis epilepsy. Glycyrrhizin has shown potential as a DMT epilepsy due to its multiple diverse mechanisms. Previous studies suggest glycyrrhizin may regulate key processes involved pathogenesis, such neuroinflammation cell death, but effects on pyroptosis have not been reported. This study employed bioinformatics techniques identify molecular treatment then validated using kainic acid-induced status epilepticus mouse model. significantly prolonged seizure latency, reduced duration, alleviated Molecular experiments indicated through mediation high mobility group box 1 (HMGB1)/Toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) signaling pathway. exerts neuroprotective anticonvulsant by regulating via HMGB1/TLR4/NF-κB pathway, offering novel insights into

Язык: Английский

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Dietary protein requirement of Chinese hook snout carp (Opsariichthys bidens) and transcriptomic analysis of the liver in response to different protein diets

Aquaculture Reports, Год журнала: 2025, Номер 40, С. 102637 - 102637

Опубликована: Янв. 16, 2025

Язык: Английский

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HDAC1 Promotes Hippocampal Neuronal Pyroptosis in Epileptic Mice Through the miR-15a-5p/Caspase-1 Axis

Neurochemical Research, Год журнала: 2025, Номер 50(2)

Опубликована: Март 25, 2025

Язык: Английский

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Non-coding RNAs modulate pyroptosis in diabetic cardiomyopathy: A comprehensive review

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142865 - 142865

Опубликована: Апрель 1, 2025

Язык: Английский

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