Salvinorin A ameliorates pilocarpine-induced seizures by regulating hippocampal microglia polarization

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 335, P. 118697 - 118697

Published: Aug. 16, 2024

Language: Английский

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Glycyrrhizin as a potential disease-modifying therapy for epilepsy: insights into targeting pyroptosis to exert neuroprotective and anticonvulsant effects

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 6, 2025

For patients with epilepsy, antiseizure medication remains the primary treatment; however, it is ineffective in approximately 30% of cases. These experience progressive neuronal damage and poor outcomes. Therefore, there an urgent need for disease-modifying therapy (DMT) that targets pathogenesis epilepsy. Glycyrrhizin has shown potential as a DMT epilepsy due to its multiple diverse mechanisms. Previous studies suggest glycyrrhizin may regulate key processes involved pathogenesis, such neuroinflammation cell death, but effects on pyroptosis have not been reported. This study employed bioinformatics techniques identify molecular treatment then validated using kainic acid-induced status epilepticus mouse model. significantly prolonged seizure latency, reduced duration, alleviated Molecular experiments indicated through mediation high mobility group box 1 (HMGB1)/Toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) signaling pathway. exerts neuroprotective anticonvulsant by regulating via HMGB1/TLR4/NF-κB pathway, offering novel insights into

Language: Английский

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Dietary protein requirement of Chinese hook snout carp (Opsariichthys bidens) and transcriptomic analysis of the liver in response to different protein diets

Aquaculture Reports, Journal Year: 2025, Volume and Issue: 40, P. 102637 - 102637

Published: Jan. 16, 2025

Language: Английский

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HDAC1 Promotes Hippocampal Neuronal Pyroptosis in Epileptic Mice Through the miR-15a-5p/Caspase-1 Axis

Neurochemical Research, Journal Year: 2025, Volume and Issue: 50(2)

Published: March 25, 2025

Language: Английский

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Non-coding RNAs modulate pyroptosis in diabetic cardiomyopathy: A comprehensive review

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142865 - 142865

Published: April 1, 2025

Language: Английский

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