Effect of natural products on host cell autophagy induced by Influenza A virus infection DOI Creative Commons

Xiaopan Liu,

Qingsen Wang

Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14

Опубликована: Сен. 30, 2024

Influenza A virus (IAV) can cause seasonal epidemics and global pandemics, posing serious threats to public health, making a deeper understanding of its biological characteristics effective countermeasure strategies essential. Autophagy not only maintains cellular homeostasis but also plays an important role in host defense against IAV infection. However, the relationship between autophagy is complex, antiviral drugs are yet available. Natural products have shown excellent potential disease control due their diversity multi-targeting. This review focuses on discusses targeting autophagic pathways for development new therapies. Particularly, use plant extracts as modulators has garnered attention non-toxic nature cost-effectiveness, which provides strong support future that help inhibit viral infections slow down progression.

Язык: Английский

Exploring the Anti-PANoptosis Mechanism of Dachaihu Decoction Against Sepsis-Induced Acute Lung Injury: Network Pharmacology, Bioinformatics, and Experimental Validation DOI Creative Commons
Zhen Yang,

Xingyu Kao,

Lin Zhang

и другие.

Drug Design Development and Therapy, Год журнала: 2025, Номер Volume 19, С. 349 - 368

Опубликована: Янв. 1, 2025

Dachaihu decoction (DCHD) is a common Chinese medicine formula against sepsis-induced acute lung injury (SALI). PANoptosis novel type of programmed cell death. Nevertheless, The mechanisms DCHD SALI via anti-PANoptosis remains unknown. First, we identified the intersecting targets among DCHD, SALI, and using relevant databases published literature. Then, protein-protein interaction (PPI) network, molecular docking, functional enrichment analysis were conducted. In vivo, cecal ligation puncture (CLP) was used to construct sepsis mouse model, therapeutic effects on evaluated hematoxylin eosin (H&E) staining, quantitative real-time PCR (qRT-PCR), ELISA. Finally, qRT-PCR, immunofluorescence Western blotting verify effect DCHD-containing serum (DCHD-DS) LPS-induced RAW 264.7 macrophages in vitro. 82 by mapping PANoptosis. Enrichment showed that modulating tumor necrosis factor (TNF), AGE-RAGE, phosphoinositide 3-kinase (PI3K)-AKT, Toll-like receptor signaling pathways targeting Casp3, cellular antigen p53 (TP53), B-cell lymphoma 2 (Bcl2), toll-like receptor-4 (TLR4), STAT3, STAT1, RELA, NF-κB1, myeloid leukemia-1 (MCL1), JUN, IL-1β, HSP90AA1, Casp9, Casp8, Bcl2l1. Molecular docking revealed key components have high binding affinity core targets. improved histopathological injury, reduced inflammatory expression, alleviated oxidative stress tissues. vitro, DCHD-DS morphology changes, release pro-inflammatory factors, p65 nucleus aggregation. Furthermore, verified inhibited downregulating PI3K/AKT/NF-κB signalling pathway. attenuates inhibiting control Our study provides solid foundation for investigating its clinical application treatment SALI.

Язык: Английский

Процитировано

1
Paeoniflorin modulates AGEs/RAGE/P38MAPK/ERK/mTOR autophagy pathway to improve cognitive dysfunction in MRL/lpr mice DOI

Honghui Tang,

Teng Ma, Yanxin Wang

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 141765 - 141765

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Targeting FABP4 to Inhibit AGEs‐RAGE/NF‐κB Signalling Effectively Ameliorates Nucleus Pulposus Dysfunction and Angiogenesis in Obesity‐Related Intervertebral Disc Degeneration DOI Creative Commons
Lin Han, Fudong Li, Huiqiao Wu

и другие.

Cell Proliferation, Год журнала: 2025, Номер unknown

Опубликована: Март 16, 2025

ABSTRACT Intervertebral disc degeneration (IVDD) is a primary contributor to low back pain, posing significant social and economic burdens. Increasing evidence shows that obesity contributes IVDD, yet the underlying mechanisms remain elusive. Here, we firstly revealed causal correlation between IVDD via two‐sample mendelian randomization analysis identified fatty acid‐binding protein 4 (FABP4) as potential regulator associate obesity. Elevated FABP4 expression promoted extracellular matrix (ECM) disequilibrium angiogenesis exacerbate progression. Genetically knocking out or pharmacologically inhibiting in high‐fat diet‐induced mice alleviated IVDD. Mechanistically, activated mammalian target of rapamycin complex 1 (mTORC1), which upregulated expression, leading accumulation advanced glycation end‐products (AGEs) intervertebral tissue. AGEs further NF‐κB signalling pathway, exacerbating ECM degradation neovascularization. Conversely, rapamycin‐mediated inhibition mTORC1 suppressed nucleus pulposus cells (NPCs), alleviating vivo. Collectively, our findings reveal critical role obesity‐induced mTORC1‐FABP4 axis during Targeting may represent promising therapeutic strategy for obese individuals.

Язык: Английский

Процитировано

0
NLRP3 Inflammasome-mediated pyroptosis in acute lung injury: Roles of main lung cell types and therapeutic perspectives DOI
Jing Wang, Lulu Li, Zhen‐Ao Zhao

и другие.

International Immunopharmacology, Год журнала: 2025, Номер 154, С. 114560 - 114560

Опубликована: Апрель 7, 2025

Язык: Английский

Процитировано

0
Andrographolide attenuates PM2.5-induced blood–brain barrier damage via antioxidant and PI3K/AKT/mTOR/NRF2 pathways DOI
Kai Kang, Yannan Zhang, Geng Yang

и другие.

International Immunopharmacology, Год журнала: 2025, Номер 157, С. 114764 - 114764

Опубликована: Май 8, 2025

Язык: Английский

Процитировано

0
Isoginkgetin inhibits macrophage activation and ferroptosis of lung epithelial cells under lipopolysaccharide-induced immunological stress via HOXA5-dependent inhibition of the TLR4/NF-κΒ signaling pathway DOI
Jian Lu,

Aiming Li,

Qunying Feng

и другие.

Toxicology and Applied Pharmacology, Год журнала: 2025, Номер unknown, С. 117413 - 117413

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Macrophage‑driven pathogenesis in acute lung injury/acute respiratory disease syndrome: Harnessing natural products for therapeutic interventions (Review) DOI Creative Commons

Jincun Li,

Wenyu Ma,

Zilei Tang

и другие.

Molecular Medicine Reports, Год журнала: 2024, Номер 31(1)

Опубликована: Ноя. 4, 2024

Acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) is a common disease characterized by hypoxemia and distress. It associated with high morbidity mortality. Due to the complex pathogenesis of ALI, clinical management patients ALI/ARDS challenging, resulting in numerous post‑treatment sequelae compromising quality life patients. Macrophages, as class innate immune cells, play an important role ALI/ARDS. In recent years, functions phenotypes macrophages have been better understood due development flow cytometry, immunofluorescence, single‑cell sequencing spatial genomics. However, no macrophage‑targeted drugs for treatment currently exist practice. Natural products are drug development, it has shown that natural compounds from herbal medicine can alleviate caused various factors modulating macrophage abnormalities. present review, modulate abnormalities treat introduced, their mechanisms action, discovered previous five years (2019‑2024), presented. This will provide novel ideas directions further research, develop new

Язык: Английский

Процитировано

1
Effect of natural products on host cell autophagy induced by Influenza A virus infection DOI Creative Commons

Xiaopan Liu,

Qingsen Wang

Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14

Опубликована: Сен. 30, 2024

Influenza A virus (IAV) can cause seasonal epidemics and global pandemics, posing serious threats to public health, making a deeper understanding of its biological characteristics effective countermeasure strategies essential. Autophagy not only maintains cellular homeostasis but also plays an important role in host defense against IAV infection. However, the relationship between autophagy is complex, antiviral drugs are yet available. Natural products have shown excellent potential disease control due their diversity multi-targeting. This review focuses on discusses targeting autophagic pathways for development new therapies. Particularly, use plant extracts as modulators has garnered attention non-toxic nature cost-effectiveness, which provides strong support future that help inhibit viral infections slow down progression.

Язык: Английский

Процитировано

0