Microbial Pathogenesis, Год журнала: 2024, Номер unknown, С. 107227 - 107227
Опубликована: Дек. 1, 2024
Язык: Английский
Molecules, Год журнала: 2025, Номер 30(1), С. 196 - 196
Опубликована: Янв. 6, 2025
Pueraria montana var. lobata (Willd.) Maesen & S.M.Almeida ex Sanjappa Predeep (P. lobata) is a medicinal herb widely used in the food and pharmaceutical industries, studies have shown that P. possesses significant anti-inflammatory pharmacological activities. In this paper, total of 16 compounds were isolated identified from lobata, among which 1–3, 7, 14, for first time. The results an vitro activity screening assay showed 1, 4, 6, 8, 15 able to significantly reduce levels pro-inflammatory cytokines IL-6 IL-1β LPS-induced RAW264.7 macrophages, with most obvious effect produced by compound 6 (formononetin), while formononetin was number macrophages at site inflammation transgenic zebrafish. addition, network analysis revealed closely related autophagy polarization targets such as TNF, EGFR, PTGS2, ESR1. validation experiments could enhance expression LCII/LCI P62 protein, CD86, CD206, further indicated regulating macrophage processes.
Язык: Английский
Процитировано
1
Food Bioscience, Год журнала: 2024, Номер 62, С. 105431 - 105431
Опубликована: Ноя. 8, 2024
Язык: Английский
Процитировано
3
Pharmaceuticals, Год журнала: 2025, Номер 18(3), С. 413 - 413
Опубликована: Март 14, 2025
Astragali Radix (AR), a traditional Chinese herbal medicine, is derived from the dried roots of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao (A. mongholicus, AMM) or Bge membranaceus, AM). According to medicine (TCM) theory, AR believed tonify qi, elevate yang, consolidate body’s surface reduce sweating, promote diuresis and swelling, generate body fluids, nourish blood. It has been widely used treat general weakness chronic illnesses improve overall vitality. Extensive research identified various medicinal properties AR, including anti-tumor, antioxidant, cardiovascular-protective, immunomodulatory, anti-inflammatory, anti-diabetic, neuroprotective effects. With advancements in technology, methods such as computer-aided drug design (CADD) artificial intelligence (AI) are increasingly being applied development TCM. This review summarizes progress on over past decades, providing comprehensive overview its efficacy, botanical characteristics, distribution, chemical constituents, phytochemistry. aims enhance researchers’ understanding pharmaceutical potential, thereby facilitating further utilization.
Язык: Английский
Процитировано
0
Critical Reviews in Food Science and Nutrition, Год журнала: 2025, Номер unknown, С. 1 - 24
Опубликована: Март 27, 2025
The gut barrier, composed of physical, secretory, immunological, and biological components, serves as the first line defense against external threats. commensal microbiota not only functions a barrier to maintain intestinal homeostasis but also produces metabolites that regulate integrity. Increasing evidence suggests dysfunction is linked gastrointestinal diseases, autoimmune disorders, neurological conditions. Plant food-derived bioactive components exhibit diverse bioactivities, including ability modulate improve function, potentially preventing chronic diseases. This review explores mechanisms underlying disruption caused by drugs, diet, pathogenic infections, alcohol. Additionally, it provides comprehensive summary beneficial effects specific plant on function homeostasis, along with their mechanisms. By elucidating these interactions, this offers valuable insights for developing safer, more effective, affordable plant-based strategies prevent or mitigate dysfunction. Understanding role compounds in health may contribute novel dietary interventions aimed at strengthening defenses reducing risk diseases associated impairment.
Язык: Английский
Процитировано
0
Microbial Pathogenesis, Год журнала: 2024, Номер unknown, С. 107227 - 107227
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
1