Utilization of natural products in diverse pathogeneses of diseases associated with single or double DNA strand damage repair
Chinese Medicine,
Год журнала:
2025,
Номер
20(1)
Опубликована: Апрель 7, 2025
Abstract
The
appearance
of
DNA
damage
often
involves
the
participation
related
enzymes,
which
can
affect
onset
and
development
various
diseases.
Several
natural
active
compounds
have
been
found
to
efficiently
adjust
activity
crucial
enzymes
associated
with
single
or
double-strand
damage,
thus
demonstrating
their
promise
in
treating
This
paper
provides
an
in-depth
examination
summary
these
modulation
mechanisms,
leading
a
thorough
review
subject.
connection
between
disease
is
explored
through
analysis
structural
characteristics
compounds.
By
reviewing
how
different
scholarly
sources
describe
identical
structures
using
varied
terminology,
this
study
also
delves
into
effects
on
enzyme
regulation.
offers
potentially
be
used
therapeutically
influence
key
activities
expression
levels,
turn
process
repair
(DDR).
These
shown
not
only
reduce
occurrence
but
boost
efficiency
processes,
presenting
new
therapeutic
opportunities
for
conditions
such
as
cancer
other
pathologies.
Future
research
should
focus
clarifying
exact
mechanisms
maximize
clinical
utility
support
creation
novel
approaches
prevention
treatment.
Graphical
abstract
Язык: Английский
Pharmacology and mechanisms of apigenin in preventing osteoporosis
Lin Sun,
Wang Yincang,
Du Jiazhe
и другие.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 12, 2024
Osteoporosis
(OP)
stands
as
the
most
prevalent
systemic
skeletal
condition
associated
with
aging.
The
current
clinical
management
of
OP
predominantly
depends
on
anti-resorptive
and
anabolic
agents.
Nevertheless,
prolonged
use
some
these
medications
has
been
observed
to
reduce
efficacy
elevate
adverse
effects.
Given
necessity
for
sustained
or
even
lifelong
treatment
OP,
identification
drugs
that
are
not
only
effective
but
also
safe
cost-efficient
is
utmost
significance.
As
disease
paradigms
continue
evolve
recent
advancements
in
research
come
light,
certain
plant-derived
compounds
have
emerged,
presenting
notable
benefits
OP.
This
review
primarily
explores
pharmacological
properties
apigenin
elucidates
its
therapeutic
mechanisms
context
insights
provided
herein
aspire
offer
a
foundation
judicious
forthcoming
research,
particularly
within
scope
Язык: Английский