Diurnal transcriptome landscape of a multi-tissue response to time-restricted feeding in mammals

Cell Metabolism, Год журнала: 2023, Номер 35(1), С. 150 - 165.e4

Опубликована: Янв. 1, 2023

Time-restricted feeding (TRF) is an emerging behavioral nutrition intervention that involves a daily cycle of and fasting. In both animals humans, TRF has pleiotropic health benefits arise from multiple organ systems, yet the molecular basis TRF-mediated not well understood. Here, we subjected mice to isocaloric ad libitum (ALF) or western diet examined gene expression changes in samples taken 22 organs brain regions collected every 2 h over 24-h period. We discovered profoundly impacts expression. Nearly 80% all genes show differential rhythmicity under at least one tissue. Functional annotation these revealed tissue- pathway-specific TRF. These findings resources provide critical foundation for future mechanistic studies will help guide human time-restricted eating (TRE) interventions treat various disease conditions with without pharmacotherapies.

Язык: Английский

---

Circadian clock communication during homeostasis and ageing

Nature Reviews Molecular Cell Biology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 3, 2025

Язык: Английский

---

Circadian regulation of liver function: from molecular mechanisms to disease pathophysiology

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2023, Номер 20(11), С. 695 - 707

Опубликована: Июнь 8, 2023

Язык: Английский

---

Daytime-restricted feeding enhances running endurance without prior exercise in mice

Nature Metabolism, Год журнала: 2023, Номер 5(7), С. 1236 - 1251

Опубликована: Июнь 26, 2023

Язык: Английский

---

Uridine and its role in metabolic diseases, tumors, and neurodegenerative diseases

Frontiers in Physiology, Год журнала: 2024, Номер 15

Опубликована: Фев. 29, 2024

Uridine is a pyrimidine nucleoside found in plasma and cerebrospinal fluid with concentration higher than the other nucleosides. As simple metabolite, uridine plays pivotal role various biological processes. In addition to nucleic acid synthesis, critical glycogen synthesis through formation of diphosphate glucose which promotes production UDP-GlcNAc hexosamine biosynthetic pathway supplies for O-GlcNAcylation. This process can regulate protein modification affect its function. Moreover, has an effect on body temperature circadian rhythms, metabolic rate expression genes. Abnormal levels blood have been people diabetes obesity, suggesting link dysregulation disorders. At present, metabolism lipid controversial, mechanism not clear, but it shows trend long-term damage short-term benefit. Therefore, maintaining homeostasis essential basic functions normal metabolism. article summarizes latest findings about effects potential as therapeutic target treatment

Язык: Английский

---

The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research

Nature Metabolism, Год журнала: 2025, Номер unknown

Опубликована: Март 17, 2025

Язык: Английский

---

Circadian disruption of feeding-fasting rhythm and its consequences for metabolic, immune, cancer, and cognitive processes

Biomedical Journal, Год журнала: 2025, Номер unknown, С. 100827 - 100827

Опубликована: Янв. 1, 2025

The circadian system is composed by a central hypothalamic clock at the suprachiasmatic nuclei (SCN) that communicates with peripheral oscillators for daily coordination of behavior and physiology. SCN entrain to environmental 24-h light-dark (LD) cycle drive rhythms internal synchronizers such as core body temperature, hypothalamic-hypophysary hormones, sympathetic/parasympathetic activity, well behavioral feeding-fasting rhythms, which supply signals setting molecular clocks tissues. Steady phase relationships between keep homeostatic processes microbiota/microbiome composition/activity, metabolic supply/demand, energy balance, immunoinflammatory process, sleep amount quality, psychophysiological stress, etc. Indeed, risk health alterations increase when these are chronically changed prompting disruption (CD), occurring after sudden LD changes (so-called jet-lag), or due activity/feeding-rest/fasting rhythm respect cycles (as humans subjected nightwork, restricting food access rest in mice). Typical pathologies observed animal models CD epidemiological studies include syndrome, type-2 diabetes, obesity, chronic inflammation, cancer, disruption, decrease physical cognitive performance, mood, among others. present review discusses different aspects physiological dysregulations having altered potential translation human health.

Язык: Английский

---

Dietary timing enhances exercise by modulating fat-muscle crosstalk via adipocyte AMPKα2 signaling

Cell Metabolism, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

---

Circadian Regulation of Cardiac Arrhythmias and Electrophysiology

Circulation Research, Год журнала: 2024, Номер 134(6), С. 659 - 674

Опубликована: Март 14, 2024

Circadian rhythms in physiology and behavior are ≈24-hour biological cycles regulated by internal clocks (ie, circadian clocks) that optimize organismal homeostasis response to predictable environmental changes. These present virtually all cells the body, including cardiomyocytes. Many decades ago, clinicians researchers became interested studying daily patterns of triggers for sudden cardiac death, incidence arrhythmias. This review highlights historical contemporary studies examining role day/night timing cardiovascular events, delves into changes these events over last few decades, discusses disease-specific differences events. The current understanding environmental, behavioral, mechanisms regulate electrophysiology is examined with a focus on regulation ion channels channel regulatory genes. Understanding contribution arrhythmia susceptibility death will be essential developing future chronotherapies.

Язык: Английский

---

Meta-analysis of Diurnal Transcriptomics in Mouse Liver Reveals Low Repeatability of Rhythm Analyses

Journal of Biological Rhythms, Год журнала: 2023, Номер 38(6), С. 556 - 570

Опубликована: Июнь 29, 2023

To assess the consistency of biological rhythms across studies, 57 public mouse liver tissue timeseries totaling 1096 RNA-seq samples were obtained and analyzed. Only control groups each study included, to create comparable data. Technical factors in library preparation largest contributors transcriptome-level differences, beyond or experiment-specific such as lighting conditions. Core clock genes remarkably consistent phase all studies. Overlap identified rhythmic studies was generally low, with no pair having over 60% overlap. Distributions phases significant inconsistent but that consistently had acrophase clustering near ZT0 ZT12. Despite discrepancies between single-study analyses, cross-study analyses found substantial consistency. Running compareRhythms on a median only 11% 1 2 Data integrated joint individual variance estimate (JIVE) analysis, which showed top components within-study variation are determined by time day. A shape-invariant model random effects fit identify underlying shape rhythms, including identifying 72 multiple peaks.

Язык: Английский

---