AJP Regulatory Integrative and Comparative Physiology,
Год журнала:
2024,
Номер
327(1), С. R109 - R121
Опубликована: Май 20, 2024
Rhythmic
feeding
behavior
is
critical
for
regulating
phase
and
amplitude
in
the
≈24-h
variation
of
heart
rate
(RR
intervals),
ventricular
repolarization
(QT
core
body
temperature
mice.
We
hypothesized
changes
cardiac
electrophysiology
associated
with
were
secondary
to
temperature.
Telemetry
was
used
record
electrocardiograms
mice
during
ad
libitum-fed
conditions
after
inverting
normal
by
restricting
food
access
light
cycle.
Light
cycle-restricted
modified
24-h
rhythms
RR
QT
intervals,
realign
new
time.
Changes
alone
could
not
account
intervals.
Heart
variability
analysis
inhibiting
β-adrenergic
muscarinic
receptors
suggested
that
intervals
autonomic
signaling.
In
contrast,
closely
mirrored
Studies
at
thermoneutrality
confirmed
daily
interval,
but
primarily
reflected
(even
conditions).
Correcting
interval
differences
helped
unmask
prolongation
starting
a
mouse
model
long
syndrome.
conclude
alters
signaling
regulate
respectively.
Cell Metabolism,
Год журнала:
2023,
Номер
35(1), С. 150 - 165.e4
Опубликована: Янв. 1, 2023
Time-restricted
feeding
(TRF)
is
an
emerging
behavioral
nutrition
intervention
that
involves
a
daily
cycle
of
and
fasting.
In
both
animals
humans,
TRF
has
pleiotropic
health
benefits
arise
from
multiple
organ
systems,
yet
the
molecular
basis
TRF-mediated
not
well
understood.
Here,
we
subjected
mice
to
isocaloric
ad
libitum
(ALF)
or
western
diet
examined
gene
expression
changes
in
samples
taken
22
organs
brain
regions
collected
every
2
h
over
24-h
period.
We
discovered
profoundly
impacts
expression.
Nearly
80%
all
genes
show
differential
rhythmicity
under
at
least
one
tissue.
Functional
annotation
these
revealed
tissue-
pathway-specific
TRF.
These
findings
resources
provide
critical
foundation
for
future
mechanistic
studies
will
help
guide
human
time-restricted
eating
(TRE)
interventions
treat
various
disease
conditions
with
without
pharmacotherapies.
Frontiers in Physiology,
Год журнала:
2024,
Номер
15
Опубликована: Фев. 29, 2024
Uridine
is
a
pyrimidine
nucleoside
found
in
plasma
and
cerebrospinal
fluid
with
concentration
higher
than
the
other
nucleosides.
As
simple
metabolite,
uridine
plays
pivotal
role
various
biological
processes.
In
addition
to
nucleic
acid
synthesis,
critical
glycogen
synthesis
through
formation
of
diphosphate
glucose
which
promotes
production
UDP-GlcNAc
hexosamine
biosynthetic
pathway
supplies
for
O-GlcNAcylation.
This
process
can
regulate
protein
modification
affect
its
function.
Moreover,
has
an
effect
on
body
temperature
circadian
rhythms,
metabolic
rate
expression
genes.
Abnormal
levels
blood
have
been
people
diabetes
obesity,
suggesting
link
dysregulation
disorders.
At
present,
metabolism
lipid
controversial,
mechanism
not
clear,
but
it
shows
trend
long-term
damage
short-term
benefit.
Therefore,
maintaining
homeostasis
essential
basic
functions
normal
metabolism.
article
summarizes
latest
findings
about
effects
potential
as
therapeutic
target
treatment
Circulation Research,
Год журнала:
2024,
Номер
134(6), С. 659 - 674
Опубликована: Март 14, 2024
Circadian
rhythms
in
physiology
and
behavior
are
≈24-hour
biological
cycles
regulated
by
internal
clocks
(ie,
circadian
clocks)
that
optimize
organismal
homeostasis
response
to
predictable
environmental
changes.
These
present
virtually
all
cells
the
body,
including
cardiomyocytes.
Many
decades
ago,
clinicians
researchers
became
interested
studying
daily
patterns
of
triggers
for
sudden
cardiac
death,
incidence
arrhythmias.
This
review
highlights
historical
contemporary
studies
examining
role
day/night
timing
cardiovascular
events,
delves
into
changes
these
events
over
last
few
decades,
discusses
disease-specific
differences
events.
The
current
understanding
environmental,
behavioral,
mechanisms
regulate
electrophysiology
is
examined
with
a
focus
on
regulation
ion
channels
channel
regulatory
genes.
Understanding
contribution
arrhythmia
susceptibility
death
will
be
essential
developing
future
chronotherapies.
Biomedical Journal,
Год журнала:
2025,
Номер
unknown, С. 100827 - 100827
Опубликована: Янв. 1, 2025
The
circadian
system
is
composed
by
a
central
hypothalamic
clock
at
the
suprachiasmatic
nuclei
(SCN)
that
communicates
with
peripheral
oscillators
for
daily
coordination
of
behavior
and
physiology.
SCN
entrain
to
environmental
24-h
light-dark
(LD)
cycle
drive
rhythms
internal
synchronizers
such
as
core
body
temperature,
hypothalamic-hypophysary
hormones,
sympathetic/parasympathetic
activity,
well
behavioral
feeding-fasting
rhythms,
which
supply
signals
setting
molecular
clocks
tissues.
Steady
phase
relationships
between
keep
homeostatic
processes
microbiota/microbiome
composition/activity,
metabolic
supply/demand,
energy
balance,
immunoinflammatory
process,
sleep
amount
quality,
psychophysiological
stress,
etc.
Indeed,
risk
health
alterations
increase
when
these
are
chronically
changed
prompting
disruption
(CD),
occurring
after
sudden
LD
changes
(so-called
jet-lag),
or
due
activity/feeding-rest/fasting
rhythm
respect
cycles
(as
humans
subjected
nightwork,
restricting
food
access
rest
in
mice).
Typical
pathologies
observed
animal
models
CD
epidemiological
studies
include
syndrome,
type-2
diabetes,
obesity,
chronic
inflammation,
cancer,
disruption,
decrease
physical
cognitive
performance,
mood,
among
others.
present
review
discusses
different
aspects
physiological
dysregulations
having
altered
potential
translation
human
health.
Seminars in Liver Disease,
Год журнала:
2022,
Номер
42(02), С. 113 - 121
Опубликована: Март 9, 2022
Circadian
rhythms
are
approximately
24-hour
cycles
of
variation
in
physiological
processes,
gene
expression,
and
behavior.
They
result
from
the
interplay
internal
biological
clocks
with
daily
environmental
rhythms,
including
light/dark
feeding/fasting.
Note
that
liver
metabolic
processes
have
been
known
for
almost
100
years.
Modern
studies
reveal
that,
like
metabolism,
hepatic
expression
is
highly
rhythmic.
Genetic
or
changes
can
disrupt
circadian
liver,
leading
to
disorders
hepatocellular
carcinoma.
In
this
review,
we
summarize
current
understanding
mechanisms
regulating
rhythmic
highlighting
roles
transcription
factors
comprise
core
clock
molecular
as
well
noncanonical
regulators.
We
emphasize
plasticity
it
responds
multiple
inputs
external
environments
potential
medicine
impact
liver-related
diseases.
