Exploring and leveraging aggregation effects on reactive oxygen species generation in photodynamic therapy

Aggregate, Год журнала: 2024, Номер 5(4)

Опубликована: Март 10, 2024

Abstract Aggregate‐level photodynamic therapy (PDT) has attracted significant interest and driven substantial advances in multifunction phototheranostic platforms. As exemplified by two typical instances of aggregation‐caused quenching reactive oxygen species (ROS) aggregation‐induced generation ROS, the aggregation effect plays a role on ROS photosensitizers (PSs), which is worthy in‐depth exploration full utilization. However, contrast to well‐developed researches luminescence, studies concerning are currently relatively nascent disjointed stage, lacking guidance from firmly established research paradigm. To advance this regard, review aims at providing consolidated overview fundamental principles status effects generation. Here, can be organized into main facets. One involves comparison between isolated state aggregated state, mainly conducted methods changing solvent environments adding adjuvants given solvent. The other underscores distinctions different aggregate states, consisting three parts, namely within same or categories based classification single‐component multicomponent aggregates. In endeavor, we will present our views current methodologies that explore how affects highlight design strategies leverage optimize PS regiments. We aspire propel advancement platforms accelerate clinical implementation precision medicine, inspire more contributions aggregate‐level photophysics photochemistry, pushing science materials forward.

Язык: Английский

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Design Strategy of PepNzymes-SH for an Emerging Catalyst with Serine Hydrolase-Like Functionality

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

Serine hydrolases, as a class of green catalysts with hydrolytic and dehydrating activities, hold significant application value in the fields biosynthesis organic synthesis. However, practical applications face numerous challenges, including maintaining enzyme stability managing usage costs. PepNzymes-SH, an emerging catalytic material enzyme-like activity, overcomes operational limitations natural enzymes holds great promise substitute for hydrolases. Unfortunately, systematic review design strategies PepNzymes-SH is currently lacking. The core significance this report lies providing researchers comprehensive understanding theoretical guidance through summarization performance evaluation different PepNzymes-SH. This summarizes simulating enhancing serine hydrolase active sites, oxyanion holes, hydrophobic environmental structures. By comparing their we assess changes brought about by strategies. Furthermore, chemical, biomedicine, are also discussed.

Язык: Английский

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Innovation leading development: a glimpse into three-dimensional bioprinting in Israel

Bio-Design and Manufacturing, Год журнала: 2024, Номер 7(3), С. 358 - 382

Опубликована: Апрель 29, 2024

Язык: Английский

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Harnessing Amino Acid Modularity for Programmable Function in Covalent Peptide Assemblies

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 9, 2025

Covalent peptide assembly leverages robust covalent bonds and dynamic non-covalent interactions to provide enhanced stability introduce diverse functionalities. Nevertheless, it remains significantly challenging achieve modular control over the structural diversity functional complexity while elucidating how specific amino acid sequences contribute these processes. Here, systematic encoding of derivative characteristics is demonstrated through modularity enable precise both in assemblies. By systematically screening single substitutions pentapeptides using tyrosine crosslinking, a library constructs developed. Each construct tailored exhibit distinct properties, including charge repulsion, aggregation-induced quenching, disassembly behavior, redox responsiveness. The strategic manipulation sequence composition, individual assemblies combinatorial systems, enables programmable complexity. This approach yields various module-specific functions, frustrated growth, hierarchical hollow architecture formation, affinity enrichment, stimuli-responsive fluorescence signal amplification. work establishes framework for design materials with functionalities, advancing development next-generation multicomponent technologies characterized by unprecedented adaptability.

Язык: Английский

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Surface Matters: How to Incorporate Conjugates in Lipid Nanoparticles Fighting Glioblastoma

Опубликована: Янв. 1, 2025

Язык: Английский

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Nanoengineered Self-Assembling Peptides with Increased Proteolytic Stability Promote Wound Healing

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Фев. 12, 2025

The copper complex of the tripeptide glycine-histidine-lysine (GHK) has proven benefits in wound healing and tissue remodeling by promoting blood vessel growth increasing skin oxygen levels, but its activity is reduced body fluids due to fast proteolytic cleavage. Herein, we designed several peptides that bear GHK sequence can self-assemble into supramolecular nanostructures aiming for enhanced bioactivity. design involves a phenylalanine (F) backbone known ability form assemblies. We tested either coassembly between structural peptide F4D functional or assembly covalently bound peptides, which via glycine (F4D-GHK) lysine (F4D-KHG, i.e., inverted sequence). All assembled nanotapes, their resistance degradation was different: generated more stable Wound assays demonstrated structures have bioactivity when compared alone. Multiplex immunoassay analyses secretion key regulators process, such as cytokines, matrix metalloproteinases, factors. Altogether our data show incorporation GHK/KHG improves stability, bioactivity, efficacy healing.

Язык: Английский

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Immunostimulatory Hydrogel with Synergistic Blockage of Glutamine Metabolism and Chemodynamic Therapy for Postoperative Management of Glioblastoma

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 20, 2025

Abstract Glioblastoma multiforme (GBM) is one of the most lethal malignant brain tumors in central nervous system. Patients face many challenges after surgery, including tumor recurrence, intracranial pressure increase due to cavitation, and limitations associated with immediate postoperative oral chemotherapy. Here an injected peptide gel situ immunostimulatory functions developed coordinate regulation glutamine metabolism chemodynamic therapy for overcoming these obstacles. The methodology entails crafting injectable scaffolds short molecules, incorporating glutaminase inhibitor CB‐839 copper self‐assembled particles (Cu‐His NPs) renowned their (CDT) efficacy. By fine‐tuning glutamic acid production via metabolic pathways, this system not only heightens therapeutic prowess CDT but also escalates intracellular oxidative stress. This dual mechanism culminates augmented immunogenic cell death within glioblastoma cells improves a conducive immune microenvironment. Based on concept reprogramming, treatment strategy has great potential significantly reduce GBM recurrence prolong median survival murine models.

Язык: Английский

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Nanofibers in Glioma Therapy: Advances, Applications, and Overcoming Challenges

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 4677 - 4703

Опубликована: Апрель 1, 2025

Despite relentless effort to study glioma treatment, the prognosis for patients remains poor. The main obstacles include high rate of recurrence and difficulty passing blood-brain barrier (BBB) therapeutic drugs. Nanomaterials owing their special physicochemical properties have been used in a wide range fields thus far. nanodrug delivery system (NDDS) with ability crossing BBB, targeting site, maintaining drug stability controlling release, has significantly enhanced anti-tumor effect, improving patients. Aligned nanofibers (NFs) are ideal materials establish vitro models microenvironment (GME), enabling exploration mechanism cell migration invasion discover novel targets. Moreover, NFs now widely applications such as radiotherapy, phototherapy, thermotherapy immunotherapy. absolute dominance anti-glioma applications, there still some problems further optimization NDDS, impact interactions between protein corona (PC) on therapy. This paper will shed light latest systems mimicking tumor (TME), discuss how optimize NDDS eliminate or utilize nanomedicine-PC interactions.

Язык: Английский

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Surface Matters: How to Incorporate Conjugates in Lipid Nanoparticles Fighting Glioblastoma

Опубликована: Янв. 1, 2025

Язык: Английский

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Research progress in tumor therapy of carrier-free nanodrug

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 178, С. 117258 - 117258

Опубликована: Авг. 6, 2024

Carrier-free nanodrugs are a novel type of drug constructed by the self-assembly molecules without carrier involvement. They have characteristics small particle size, easy penetration various barriers, targeting tumors, and efficient release. In recent years, carrier-free become hot topic in tumor therapy as they solve problems low loading, poor biocompatibility, uptake efficiency nanodrugs. A series studies shown that play vital role treatment with similar or better effects than Based on literature published past decades, this paper first summarizes progress assembly modes nanodrugs, then describes common therapeutic modalities therapy, finally depicts existing challenges along future trends We hope review can guide design application future.

Язык: Английский

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