Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 10, 2024
Abstract
Afterglow
materials
offer
great
advantages
for
imaging,
including
ultra‐long
luminescent
lifetimes
sustained
signal
after
excitation,
high
signal‐to‐noise
ratios
due
to
minimal
tissue
autofluorescence
interference,
and
the
ability
achieve
deep
penetration
with
near‐infrared
(NIR)
afterglow.
AIEgens,
known
their
potent
singlet
oxygen
(¹O₂)
generation
during
photodynamic
therapy
(PDT),
further
enhance
approach.
Here
is
first
report
on
how
integrate
AIEgens
chemiluminescent
agents
constructing
NIR
afterglow
materials,
enabling
chemiluminescence
resonance
energy
transfer
(
CRET)‐mediated
activation
of
targeted
PDT.
DCL
/
TBQ
nanoparticles
(NPs)
exemplify
this
promising
theranostic
design.
These
NPs
exhibit
selectivity
sensitivity
toward
ONOO
−
,
a
biomarker
associated
tumors,
low
limit
detection
(46.1
n
m
).
Additionally,
boast
impressive
(2
cm)
remarkable
120‐fold
improvement
in
ratio
tumor
imaging.
Most
importantly,
significant
growth
inhibition
capabilities
are
demonstrated.
This
approach
holds
immense
potential
development
next‐generation
agents,
simultaneous
diagnosis
treatment
improved
accuracy
efficacy.
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 9, 2024
Abstract
Bacteria
share
a
longstanding
and
complex
relationship
with
humans,
playing
role
in
protecting
gut
health
sustaining
the
ecosystem
to
cause
infectious
diseases
antibiotic
resistance.
Luminogenic
materials
that
aggregation‐induced
emission
(AIE)
characteristics
have
emerged
as
versatile
toolbox
for
bacterial
studies
through
fluorescence
visualization.
Numerous
research
efforts
highlight
superiority
of
AIE
this
field.
Recent
advances
are
categorized
into
four
areas:
understanding
interactions,
antibacterial
strategies,
diverse
applications,
synergistic
applications
bacteria.
Initial
focuses
on
visualizing
unseen
bacteria
progresses
developing
strategies
involving
electrostatic
amphiphilic
luminogens
(AIEgens),
various
enhance
affinity.
progress
includes
using
photodynamic
photothermal
therapies,
toxicity
studies,
combined
therapies.
Diverse
from
environmental
disinfection
disease
treatment,
utilizing
coatings,
sensors,
wound
healing
materials,
etc.,
also
provided.
Finally,
combining
achieve
enhanced
outcomes
explored.
This
review
summarizes
developmental
trend
is
expected
provide
future
directions
advancing
methodologies.
Advanced Materials,
Год журнала:
2024,
Номер
36(38)
Опубликована: Июль 26, 2024
Abstract
One‐for‐all
phototheranostics
based
on
a
single
molecule
is
recognized
as
convenient
approach
for
cancer
treatment,
whose
efficacy
relies
precise
lesion
localization
through
multimodal
imaging,
coupled
with
the
efficient
exertion
of
phototherapy.
To
unleash
full
potential
phototheranostics,
advancement
in
both
phototheranostic
agents
and
light
delivery
methods
essential.
Herein,
an
integrated
strategy
combining
versatile
featuring
aggregation‐induced
emission,
namely
tBuTTBD,
modified
optical
fiber
to
realize
comprehensive
tumor
diagnosis
“inside‐out”
irradiation
orthotopic
breast
tumor,
proposed
first
time.
Attributed
intense
donor‐acceptor
interaction,
highly
distorted
conformation,
abundant
molecular
rotors,
loose
intermolecular
packing
upon
aggregation,
tBuTTBD
can
synchronously
undergo
second
near‐infrared
(NIR‐II)
fluorescence
photothermal
photodynamic
generation
under
laser
irradiation,
contributing
trimodal
NIR‐II
fluorescence‐photoacoustic
(PA)‐photothermal
imaging‐guided
The
treatment
further
carried
out
following
insertion
fiber,
which
fabricated
by
splicing
flat‐end
air‐core
fiber.
This
configuration
aims
enable
effective
situ
phototherapy
maximizing
energy
utilization
therapeutic
benefits.
work
not
only
enriches
palette
but
also
provides
valuable
insight
exploring
protocol
practical
treatment.
ACS Materials Letters,
Год журнала:
2024,
Номер
6(6), С. 2174 - 2185
Опубликована: Май 6, 2024
Exploring
advanced
photodynamic
strategies
to
surmount
the
firm
reliance
on
oxygen
and
limited
penetration
depth
of
excitation
light
is
great
significance
in
tumor
therapy.
Herein,
a
two-photon
excitable
type
I
photosensitizer
with
aggregation-induced
emission
characteristics,
namely
tBuT2AQ,
rationally
designed
by
simply
equipping
an
anthraquinone
(AQ)
acceptor
rotor-type
electron-donating
triphenylamine
derivatives.
The
AQ
moiety
good
electron-withdrawing
ability
significant
spin–orbit
coupling
effect
could
facilitate
generation
triplet
excitons
triggering
multichannel
intersystem
crossing.
These
further
undergo
electron
transfer
processes
enable
massive
production
reactive
species
because
redox
cycling
behaviors
mediated
carbonyl
groups
moiety.
Moreover,
planar
structure
beneficial
for
allows
deep
into
biological
tissues.
After
being
formulated
nanoparticles
acid-responsive
charge-reversible
polymers,
tBuT2AQ
can
be
accumulated
at
sites
efficiently
performs
highly
effective
treatment.
Abstract
Type
I
photosensitizers
(PSs)
with
the
ability
to
generate
reactive
oxygen
species
(ROS)
containing
superoxide
anion
and
hydroxyl
radical
have
promising
application
potential
for
treating
hypoxia
tumors,
but
deep
mechanism
of
type
II
ROS
converts
in
PSs
is
still
unclear,
it
urgent
reveal
influencing
factors
about
inducing
generation.
Herein,
six
aggregation‐induced
emission
properties,
which
were
fabricated
same
electronic
acceptor
different
donors
“π‐bridge”,
been
successfully
prepared
explore
generating
from
organic
PSs.
Experimental
results
discovered
two
molecular
structure
aggregated
environment
could
decide
efficiency
types
On
level
designing
structure,
we
that
“π‐bridge”
a
lower
energy
lowest
triplet
state
be
beneficial
triggering
production
anion,
donor
triphenylamine
was
an
important
factor
producing
than
another
dimethylamine.
aggregates
PS‐based
polymeric
nanoparticles,
bovine
serum
albumin
improve
largely
generation
anion.
Due
satisfactory
better
biocompatibility,
synthetic
showed
excellent
photodynamic
therapy
outcomes
vitro/vivo.
Nano-Micro Letters,
Год журнала:
2025,
Номер
17(1)
Опубликована: Март 10, 2025
Abstract
The
treatment
of
ammonia
nitrogen
wastewater
(ANW)
has
garnered
significant
attention
due
to
the
ecology,
and
even
biology
is
under
increasing
threat
from
over
discharge
ANW.
Conventional
ANW
methods
often
encounter
challenges
such
as
complex
processes,
high
costs
secondary
pollution.
Considerable
progress
been
made
in
employing
solar-induced
evaporators
for
treatment.
However,
there
remain
notable
barriers
transitioning
fundamental
research
practical
applications,
including
insufficient
evaporation
rates
inadequate
resistance
biofouling.
Herein,
we
propose
a
novel
evaporator,
which
comprises
bio-enzyme-treated
wood
aerogel
that
serves
water
pumping
storage
layer,
cost-effective
multi-walled
carbon
nanotubes
coated
hydrophobic/hydrophilic
fibrous
nonwoven
mat
functioning
photothermal
aggregation-induced
emission
(AIE)
molecules
incorporated
anti-biofouling
agent.
resultant
bioinspired
evaporator
demonstrates
rate
12.83
kg
m
−2
h
−1
when
treating
simulated
containing
30
wt%
NH
4
Cl
1.0
sun
illumination.
AIE-doped
exhibits
remarkable
photodynamic
antibacterial
activity
against
mildew
bacteria,
ensuring
outstanding
biofouling
extended
periods
When
enhanced
by
natural
wind
irradiation,
achieves
an
impressive
exceeding
20
.
This
advancement
represents
promising
viable
approach
effective
removal
wastewater.
Asian Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 10, 2025
Abstract
Phenazinone
chromophore
incorporating
a
carbonyl
group
into
the
skeleton
is
recently
found
to
be
new‐type
halogen‐atom‐free‐photosensitizer
possessing
superior
ability
in
singlet
oxygen
(
1
O
2
)
generation.
In
this
work,
order
gain
insight
substituent
effect
on
optical
properties
and
generation
of
phenazinone‐based
PSs,
we
have
designed
developed
derivative
with
two
5‐formyl‐2‐thienyl
substituents
which
expected
lead
improvement
light
harvesting
efficiencies.
This
work
revealed
that
introduction
phenazinone
leads
bathochromic
shift
photoabsorption
band,
but
thermodynamically
unfavorable
energy
gap
(Δ
E
ST
value
between
S
state
T
n
as
well
low
intersystem
crossing
(ISC)
constant
k
ISC
),
resulting
quantum
yield,
although
possesses
feasible
characteristics
based
El‐Sayed's
rule.
Photodynamic
therapy
(PDT)
is
an
innovative,
non-invasive,
and
selective
treatment
approach
that
has
gained
attention
as
adjunctive
in
periodontitis.
Aggregatibacter
actinomycetemcomitans
opportunistic
periodontopathogen
known
for
its
ability
to
form
biofilms.
The
objective
of
this
vitro
study
was
determine
the
anti-virulence
effect
nano-quercetin
(N-QT)-mediated
PDT
on
expression
a
gene
associated
with
biofilm
formation
A.
actinomycetemcomitans.
After
synthesis
characterization
N-QT
by
transmission
electron
microscopes
(TEM),
dynamic
light
scattering
(DLS),
zeta
potential
analysis,
fourier
transform
infrared
spectroscopy
(FTIR)
effects
different
concentrations
energy
densities
diode
laser
alone
cell
viability
were
evaluated.
then
treated
sub-lethal
doses
emitting
presence
N-QT.
Ultimately,
dose
used
investigate
metabolic
activity
actinomycetemcomitans,
generation
reactive
oxygen
species
(ROS),
changes
rcpA,
qseB,
qseC
genes
using
quantitative
real-time
polymerase
chain
reaction
(qRT-PCR)
method.
According
results,
TEM,
DLS,
potential,
FTIR
confirmed
16
512
µg/mL
irradiation
6
min
density
154.8
J/cm2
caused
significant
decrease
bacterial
count
(P
<
0.05).
8
5-min
achieved
highest
reduction
(42.9%),
while
2
4-min
yielded
lowest
(12.3%).
Using
exposure
4
5
at
103.9
129
J/cm²
led
ROS
levels
2.67-
2.83-fold
higher
than
those
control
cells,
respectively
Additionally,
resulted
2.62-,
2.85-,
3.21-fold
genes,
utilizing
shows
promise
suppressing
cellular
survival
emerges
viable
strategy
targeting
virulence.
