RGD-based self-assembling nanodrugs for improved tumor therapy

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Окт. 1, 2024

RGD-based self-assembling nanodrugs are a promising advancement in targeted cancer therapy, combining the specificity of RGD peptides with benefits nanotechnology. These enhance tumor targeting and cellular uptake while reducing off-target effects. facilitate self-assembly stable nanostructures, ensuring efficient drug delivery. Despite their potential, challenges such as immunogenicity, stability, heterogeneity, manufacturing scalability need to be addressed. Future research should focus on improving biocompatibility, advanced strategies, personalized medicine approaches, innovative techniques. Overcoming these will pave way for successful clinical translation nanodrugs, offering more effective safer treatments.

Язык: Английский

---

Self-Assembly of Metabolite Nanostructures toward Functional Biomaterials

ACS Materials Letters, Год журнала: 2024, Номер 6(2), С. 674 - 696

Опубликована: Янв. 23, 2024

Metabolites have been developed for crystals with diverse morphologies and functionalities. These materials are self-assembled into various nanostructures, exhibiting excellent piezoelectric, semiconducting, optical, thermal, mechanical properties. Due to the metabolites' biocompatibility biodegradability, metabolite-based assemblies found wide applications in wearable technologies, biomedical fields, many other areas. In this paper, we review synthesis methods self-assembly mechanisms of metabolites then discuss their versatile We also highlight recent advances energy harvesting, storage, enabled by metabolite self-assemblies identify current challenges potential directions breakthroughs studying assemblies.

Язык: Английский

---

The preparation of shikonin-based nanomedicine with robust GSH-responsiveness

Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2024, Номер 705, С. 135557 - 135557

Опубликована: Окт. 13, 2024

Язык: Английский

---

Enhancing Chemoimmunotherapy for Colorectal Cancer with Paclitaxel and Alantolactone via CD44-Targeted Nanoparticles: A STAT3 Signaling Pathway Modulation Approach

Asian Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 20(1), С. 100993 - 100993

Опубликована: Ноя. 12, 2024

Chemoimmunotherapy has the potential to enhance chemotherapy and modulate immunosuppressive tumor microenvironment by activating immunogenic cell death (ICD), making it a promising strategy for clinical application. Alantolactone (A) was found augment anticancer efficacy of paclitaxel (P) at molar ratio 1:0.5 (P:A) through induction more potent ICD via modulation STAT3 signaling pathways. Nano drug delivery systems can synergistically combine natural drugs with conventional chemotherapeutic agents, thereby enhancing multi-drug chemoimmunotherapy. To improve targeting ability bioavailability hydrophobic drugs, an amphiphilic prodrug conjugate (HA-PTX) chemically modified (PTX) hyaluronic acid (HA) as backbone. Based on this concept, CD44-targeted nanodrugs (A@HAP NPs) were developed co-delivery A P in colorectal cancer treatment, aiming achieve synergistic toxicity-based chemo-immunotherapy. The uniform size high loading capacity A@HAP NPs facilitated their accumulation within tumors enhanced permeability retention effect well HA-mediated targeting, providing solid foundation subsequent therapy immunoregulation. In vitro vivo studies demonstrated that exhibited cytotoxicity against cells while also remodeling immune-suppressive promoting antigen presentation inducing dendritic maturation, thus offering novel approach

Язык: Английский

---

Liposomal Encapsulation of Chlorambucil with a Terpyridine-Based, Glutathione-Targeted Optical Probe Facilitates Cell Entry and Cancer Cell Death

ACS Applied Bio Materials, Год журнала: 2024, Номер unknown

Опубликована: Дек. 17, 2024

The nitrogen mustard alkylating agent chlorambucil (CBL) is a critical component of chemotherapeutic regimens used in the treatment chronic lymphocytic leukemia. cancer cell-killing actions CBL are limited by glutathione (GSH) conjugation, process catalyzed GSH transferase hGSTA1-1 that triggers efflux from cells. In cell microenvironment, intracellular levels elevated to counterbalance oxidative stress generated due high glycolytic demand. As many drugs trigger death through mechanisms depend on reactive oxygen species (ROS), antioxidant capacity cells also represents barrier anticancer therapies. Here, we demonstrate heightened content can be exploited for cell-selective drug delivery. We successfully synthesized malononitrile conjugate terpyridine-based derivative

Язык: Английский

---

Fluorous Tagged Peptides for Intracellular Delivery and Biomedical Imaging

Macromolecular Bioscience, Год журнала: 2023, Номер 23(7)

Опубликована: Март 15, 2023

Fluorous tagged peptides have shown promising features for biomedical applications such as drug delivery and multimodal imaging. The bioconjugation of fluoroalkyl ligands onto cargo greatly enhances their proteolytic stability membrane penetration via a proposed "fluorine effect". also efficiently deliver other biomolecules DNA siRNA into cells co-assembly strategy. chains on with antifouling properties enable efficient gene in the presence serum proteins. Besides intracellular biomolecule delivery, amphiphilic can be used to stabilized perfluorocarbon-filled microbubbles ultrasound fluorine nucleus fluoroalkyls provides intrinsic probes background-free magnetic resonance Labeling fluorous tags radionuclide 18 F allows tracing biodistribution positron emission tomography This mini-review will discuss mechanism these applications.

Язык: Английский

---

Self-assembling peptides: Perspectives regarding biotechnological applications and vaccine development

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 259, С. 128944 - 128944

Опубликована: Дек. 23, 2023

Self-assembly involves a set of molecules spontaneously interacting in highly coordinated and dynamic manner to form specific supramolecular structure having new clearly defined properties. Many examples this occur nature many more came from research laboratories, with their number increasing every day via ongoing concerning complex biomolecules the possibility harnessing it when developing applications. As phenomenon, self-assembly has been described on very different types (biomolecules including), so review focuses what is known about peptide self-assembly, its origins, forces behind it, how properties resulting material can be tuned relation experimental considerations, some biotechnological applications (in which main protagonists are sequences capable self-assembly) yet regarding development.

Язык: Английский

---

Photocrosslinked Co‐Assembled Amino Acid Nanoparticles for Controlled Chemo/Photothermal Combined Anticancer Therapy

Small, Год журнала: 2023, Номер 20(23)

Опубликована: Дек. 28, 2023

Abstract Nanostructures formed from the self‐assembly of amino acids are promising materials in many fields, especially for biomedical applications. However, their low stability resulting weak noncovalent interactions between acid building blocks limits use. In this work, nanoparticles co‐assembled by fluorenylmethoxycarbonyl (Fmoc)‐protected tyrosine (Fmoc‐Tyr‐OH) and tryptophan (Fmoc‐Trp‐OH) crosslinked ultraviolet (UV) light irradiation. Two methods investigated to induce dimerization tyrosine, irradiating at 254 nm or 365 presence riboflavin as a photo‐initiator. For crosslinking performed nm, both Fmoc‐Tyr‐OH Fmoc‐Trp‐OH generate dimers. contrast, only participates riboflavin‐mediated under irradiation nm. The participation forming dimers leads more stable nanoparticles, allowing also perform further chemical modifications cancer anticancer drug doxorubicin (Dox) is adsorbed onto subsequently coated tannic acid‐iron complex, endowing with glutathione‐responsiveness photothermal properties, control release Dox. A remarkable efficiency obtained vitro vivo tumor‐bearing mice thanks combined chemo‐ treatment.

Язык: Английский

---

Design and Update of Multifunctional Polypeptides and Their Applications for the Prevention of Viral Infections and Cancer Immunotherapies

Polymer Reviews, Год журнала: 2023, Номер 64(2), С. 528 - 574

Опубликована: Ноя. 16, 2023

Polypeptides with repeated amino acid residues are a typical kind of biocompatible polymers and tremendous efforts have been made to synthesize them for diversified medical applications. With the deep integration biomedicine polypeptides, we can foresee progresses in antiviral infections cancer immunotherapies. Those clinical demands encourage us discuss functions-targeted polypeptides foreseeable appearing roles as RNA delivery carriers, broad-spectrum agents, nanovaccines. The functions basically determined by architectures, sequences physicochemical properties while thoughtful understanding on rational design structure-property relationship will move forward systems innovative therapies viral cancers. This review is intended help chemists know which kinds really wanted clinic inform state-of-art polypeptides. focus very recent synthetic methods, modulation architectures properties, clinically-targeted applications immunotherapies, guiding perspectives developing multifunctional

Язык: Английский

---

Immunostimulatory hydrogel with synergistic blockage of glutamine metabolism and chemodynamic therapy for postoperative management of glioblastoma

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Июль 3, 2024

Glioblastoma multiforme (GBM) stands as one of the most lethal malignant brain tumors affecting central nervous system. Post-surgery, patients encounter daunting challenges like tumor recurrence, increased intracranial pressure due to cavitation, and constraints linked with immediate postoperative oral chemotherapy. Herein, we construct an injected peptide gel in situ immunostimulatory functions harmonize regulation glutamine metabolism chemodynamic therapy tackling obstacles. The methodology entails crafting injectable scaffolds short molecules, incorporating glutaminase inhibitor CB-839 copper self-assembled particles (Cu-His NPs) renowned for their (CDT) efficacy. By fine-tuning glutamic acid production via metabolic pathways, our system not only heightens therapeutic prowess CDT but also escalates intracellular oxidative stress. This dual mechanism culminates augmented immunogenic cell death (ICD) within glioblastoma cells improves a conducive immune microenvironment. Anchored on tenets reprogramming, this treatment strategy showcases substantial promise significantly curtailing GBM prolonging median survival murine models.

Язык: Английский

---