Non-alcoholic fatty liver disease and gut microbial dysbiosis- underlying mechanisms and gut microbiota mediated treatment strategies

Reviews in Endocrine and Metabolic Disorders, Год журнала: 2023, Номер 24(6), С. 1189 - 1204

Опубликована: Окт. 16, 2023

Язык: Английский

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Interactions between Dietary Antioxidants, Dietary Fiber and the Gut Microbiome: Their Putative Role in Inflammation and Cancer

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(15), С. 8250 - 8250

Опубликована: Июль 28, 2024

The intricate relationship between the gastrointestinal (GI) microbiome and progression of chronic non-communicable diseases underscores significance developing strategies to modulate GI microbiota for promoting human health. administration probiotics prebiotics represents a good strategy that enhances population beneficial bacteria in intestinal lumen post-consumption, which has positive impact on In addition, dietary fibers serve as significant energy source inhabiting cecum colon. Research articles reviews sourced from various global databases were systematically analyzed using specific phrases keywords investigate these relationships. There is clear association fiber intake improved colon function, gut motility, reduced colorectal cancer (CRC) risk. Moreover, state health reflected reciprocal bidirectional relationships among food, antioxidants, inflammation, body composition. They are known their antioxidant properties ability inhibit angiogenesis, metastasis, cell proliferation. Additionally, they promote survival, immune inflammatory responses, inactivate pro-carcinogens. These actions collectively contribute role prevention. different investigations, supplements containing vitamins have been shown lower risk types. contrast, some evidence suggests taking can increase cancer. Ultimately, collaborative efforts immunologists, clinicians, nutritionists, dietitians imperative designing well-structured nutritional trials corroborate clinical efficacy therapy managing inflammation preventing carcinogenesis. This review seeks explore interrelationships fiber, microbiome, with particular focus potential implications

Язык: Английский

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From Dysbiosis to Hepatic Inflammation: A Narrative Review on the Diet-Microbiota-Liver Axis in Steatotic Liver Disease

Microorganisms, Год журнала: 2025, Номер 13(2), С. 241 - 241

Опубликована: Янв. 23, 2025

The gut microbiota has emerged as a critical player in metabolic and liver health, with its influence extending to the pathogenesis progression of steatotic diseases. This review delves into gut-liver axis, dynamic communication network linking microbiome through metabolic, immunological, inflammatory pathways. Dysbiosis, characterized by altered microbial composition, contributes significantly development hepatic steatosis, inflammation, fibrosis via mechanisms such barrier dysfunction, metabolite production, systemic inflammation. Dietary patterns, including Mediterranean diet, are highlighted for their role modulating microbiota, improving axis integrity, attenuating injury. Additionally, emerging microbiota-based interventions, fecal transplantation bacteriophage therapy, show promise therapeutic strategies disease. However, challenges population heterogeneity, methodological variability, knowledge gaps hinder translational application current findings. Addressing these barriers standardized approaches integrative research will pave way microbiota-targeted therapies mitigate global burden

Язык: Английский

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Chia (Salvia hispanica L.) flour modulates the intestinal microbiota in Wistar rats fed a high-fat and high-fructose diet

Food Research International, Год журнала: 2023, Номер 172, С. 113095 - 113095

Опубликована: Июнь 10, 2023

Язык: Английский

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Game of microbes: the battle within – gut microbiota and multiple sclerosis

Gut Microbes, Год журнала: 2024, Номер 16(1)

Опубликована: Авг. 8, 2024

Multiple sclerosis (MS) is a chronic and progressive autoimmune disease of the central nervous system (CNS), with both genetic environmental factors contributing to pathobiology disease. While human leukocyte antigen (HLA) genes have emerged as strongest factor, consensus on risk are lacking. Recently, trillions microbes residing in our gut (microbiome) potential factor linked MS PwMS show microbial dysbiosis (altered microbiome). Thus, there has been strong emphasis understanding (host environmental) regulating composition microbiota mechanism(s) through which contribute disease, especially immune modulation. A better these interactions will help harness enormous therapeutic approach treating MS.

Язык: Английский

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Nicotinic acid attenuates experimental non-alcoholic steatohepatitis by inhibiting the NLRP3 inflammasome/pyroptosis pathway

Biochemical Pharmacology, Год журнала: 2023, Номер 216, С. 115762 - 115762

Опубликована: Авг. 19, 2023

Язык: Английский

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Emerging Perspectives: The Interplay of Taste Perception and Oral Microbiota Composition in Dietary Preferences and Obesity

Nutrition Research Reviews, Год журнала: 2024, Номер unknown, С. 1 - 10

Опубликована: Окт. 21, 2024

Recent advancements in sensory research have brought to light the intricate relationship between taste perception and oral microbiota, prompting investigations into their influence on human health, particularly context of dietary preferences obesity. This review aims update current understanding how microbiota choices, elucidating shared metabolic pathways food processing bacteria. Further, this outlines mechanisms underlying perception, emphasising role receptors buds shaping experiences influenced by genetic environmental factors. Notably, we explore bidirectional sensitivity, highlighting potential impact microbial composition thresholds implications for habits health outcomes, such as obesity dental caries. However, significant gaps remain, molecular linking with well long-term effects microbiota-targeted interventions. Future should focus longitudinal studies experimental interventions these connections more deeply, offering insights strategies promoting healthier behaviours managing diet-related non-communicable diseases.

Язык: Английский

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Bacterial components‐driven intrahepatic CXCR5^hi B cells are important population for MASH progression through inducing inflammation

The FASEB Journal, Год журнала: 2025, Номер 39(2)

Опубликована: Янв. 15, 2025

Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by severe liver inflammation and fibrosis due to an imbalanced immune response caused enhanced bacterial components. The progression of MASH closely linked increased permeability intestinal mucosal barrier facilitating enter components into hepatic portal venous system. B cells are important for adaptive responses enhance through cytokine production T cell activation. influenced gut microbiota, but the specific populations in their pathologic mechanism remain obscure. Here, we found that numbers highly expressing CXCR5, receptor CXCL13 chemokine, were livers MASH. CXCR5 high non-proliferating naive with inflammatory features mainly residing parenchyma affect pathology. Importantly, revealed induced stimulating TLRs. These stimulator-induced CXCR5hi express TNFα, CD80, MHC class II, leading Consistently, confirmed intravenous injection model. Ultimately, this study elucidates role mechanisms advancing progression.

Язык: Английский

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The Gut Virome and Human Health: From Diversity to Personalized Medicine

Engineering Microbiology, Год журнала: 2025, Номер unknown, С. 100191 - 100191

Опубликована: Фев. 1, 2025

Язык: Английский

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Multiple Sclerosis: A Story of the Interaction Between Gut Microbiome and Components of the Immune System

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 11, 2025

Abstract Multiple sclerosis (MS) is defined as an inflammatory disorder that chronically affects the central nervous system of young people mostly and distributed globally. It associated with degeneration demyelination myelin sheath around nerves, resulting in multiple neurological disability symptoms ranging from mild to severe cases end paralysis sometimes. MS one rising diseases globally unfortunately reduced quality life adding national economic burdens. The definite mechanism not clearly defined; however, all previous researches confirm role immune master contributor pathogenesis. Innate adaptive cells are activated peripherally then attracted toward (CNS) due breakdown blood–brain barrier. Recently, gut-brain axis was shown depend on gut metabolites produced by different microorganisms colon. difference microbiota composition between individuals responsible for diversity secreted affect responses locally or systemically when reach blood circulation brain. may enhance suppress (repeated short forms); consequently, it exacerbate ameliorate symptoms. Recent data showed some can be used adjuvant therapy other diseases. This review sheds light nature possible interaction regulation through axis, hence contributing

Язык: Английский

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