Development of Polymethine Dyes for NIR‐II Fluorescence Imaging and Therapy

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(16)

Опубликована: Март 5, 2024

Fluorescence imaging in the second near-infrared window (NIR-II) is burgeoning because of its higher fidelity monitoring physiological and pathological processes than clinical visible/the fluorescence imaging. Notably, heavily dependent on agents. So far, indocyanine green, one polymethine dyes, with good biocompatibility renal clearance only dye approved by Food Drug Administration, but it shows relatively low NIR-II brightness. Importantly, tremendous efforts are devoted to synthesizing dyes for preclinically clinically. They have shown feasibility customization structure properties fulfill various needs therapy. Herein, a timely update special focus molecular design strategies fluorescent, photoacoustic, multimodal imaging, offered. Furthermore, progress sensing biomarkers even reporting drug release illustrated. Moreover, imaging-guided therapies summarized regarding chemo-, photothermal, photodynamic, approaches. In addition, artificial intelligence pointed out potential expedite development. This comprehensive review will inspire interest among wide audience offer handbook people an dyes.

Язык: Английский

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Bioresponsive drug delivery systems

Drug Discovery Today, Год журнала: 2023, Номер 29(1), С. 103849 - 103849

Опубликована: Дек. 3, 2023

Язык: Английский

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Development of Cyclic and Acyclic Fluorescent Chemosensors for Selective Detection of Ions and Biomolecules in Water

ChemistrySelect, Год журнала: 2025, Номер 10(1)

Опубликована: Янв. 1, 2025

Abstract The intriguing effect of metal ions and biomolecules on various biological entities warrants developing selective sensitive fluorescent chemosensors in water other organic solvents. A review comparable literature related areas, including material chemistry, environmental science, supramolecular indicates that most the research work is carried out varying types existing chemosensor explores use solvents, DMSO/H₂O, methanol, DMF/HEPES systems, photoinduced electron transfer (PET)‐based chemosensors. DMSO DMF are strong polar solvents resulting fluorescence emission. Additionally, dichlorobenzene chlorobenzene employed to form gels with urea compounds, further improving sensor's functionality selectivity. Also, parallel investigations, when as a solvent, revealed decrease binding/ detection ability guest analytes since molecules strongly solvated (hydrated) moieties, whereas non‐polar (or amphiphilic molecules) found aggregations or self‐assemblies. present attempts analyze characterize water‐soluble (FCHs) into cyclic acyclic per their topological structural architectures. In addition, seminal examples synthetic FCHs, included herein, provide an understanding rational designs, fundamental properties, interactions, emerging switchable properties aqueous medium. Thus, knowledge these high affinity selectivity would facilitate synthesis novel FCHs potential future applications.

Язык: Английский

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How Advanced are Self-Assembled Nanomaterials for Targeted Drug Delivery? A Comprehensive Review of the Literature

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 2133 - 2161

Опубликована: Фев. 1, 2025

The development of effective drug delivery systems is a key focus in pharmaceutical research, aiming to enhance therapeutic efficacy while minimizing adverse effects. Self-assembled nanostructures present promising solution due their tunable properties, biocompatibility, and ability encapsulate deliver agents specific targets. This review examines recent advancements drug-based self-assembled for targeted applications, including drug-drug conjugates, polymeric-based architectures, biomolecules, peptides, DNA, squalene conjugates amphiphilic drugs. Various strategies fabricating these are discussed, with an emphasis on the design principles mechanisms underlying self-assembly potential tissues or cells. Furthermore, integration targeting ligands, stimuli-responsive moieties imaging into explored enhanced outcomes real-time monitoring. Challenges such as stability, scalability regulatory hurdles translating from bench bedside also addressed. Drug-based represent platform developing next-generation improved reduced side

Язык: Английский

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Multiscale Metal-based Nanocomposites for Bone and Joint Disease Therapies

Materials Today Bio, Год журнала: 2025, Номер 32, С. 101773 - 101773

Опубликована: Апрель 17, 2025

Bone and joint diseases are debilitating conditions that can result in significant functional impairment or even permanent disability. Multiscale metal-based nanocomposites, which integrate hierarchical structures ranging from the nanoscale to macroscale, have emerged as a promising solution this challenge. These materials combine unique properties of nanoparticles (MNPs), such enzyme-like activities, stimuli responsiveness, photothermal conversion, with advanced manufacturing techniques, 3D printing biohybrid systems. The integration MNPs within polymer ceramic matrices offers degree control over mechanical strength, antimicrobial efficacy, manner drug delivery, whilst concomitantly promoting processes osteogenesis chondrogenesis. This review highlights breakthroughs stimulus-responsive (e.g., photo-, magnetically-, pH-activated systems) for on-demand therapy their biocomposite hybrids containing cells extracellular vesicles mimic native tissue microenvironment. applications these composites extensive, bone defects, infections, tumors, degenerative diseases. emphasizes enhanced load-bearing capacity, bioactivity, be achieved through designs. Notwithstanding potential applications, barriers progress persist, including challenges related long-term biocompatibility, regulatory hurdles, scalable manufacturing. Finally, we propose future directions, machine learning-guided design patient-specific biomanufacturing accelerate clinical translation. bridge innovations macroscale functionality, revolutionary force field biomedical engineering, providing personalized regenerative solutions

Язык: Английский

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Hyaluronic Acid in Nanopharmaceuticals: An Overview

Current Issues in Molecular Biology, Год журнала: 2024, Номер 46(9), С. 10444 - 10461

Опубликована: Сен. 20, 2024

Hyaluronic acid (HA) is a naturally occurring, long, unbranched polysaccharide that plays critical role in maintaining skin structure and hydration. Its unique properties make it valuable component the field of nanopharmaceuticals. The combination HA into nanopharmaceuticals enhances its ability to interact with various therapeutic agents, improving delivery efficacy drugs. HA-based nanoparticles, including solid lipid polymeric nanogels, offer controlled release, enhanced stability, targeted agents. These innovations significantly improve outcomes reduce side effects, making an essential tool modern medicine. In general, HA-modified liposomes enhance drug encapsulation targeting, while nanoparticles (SLNs) provide core for encapsulation, offering release stability. This article provides overview potential applications recent advancements nanopharmaceuticals, emphasizing significant impact on evolving advanced strategies. By delving compatibility this review underscores promising revolutionizing

Язык: Английский

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Harnessing the power of biological macromolecules in hydrogels for controlled drug release in the central nervous system: A review

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 254, С. 127708 - 127708

Опубликована: Ноя. 1, 2023

Язык: Английский

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Ferritin‐Based Supramolecular Assembly Drug Delivery System for Aminated Fullerene Derivatives to Enhance Tumor‐Targeted Therapy

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Дек. 31, 2024

Owing to their attractive antitumor effects, aminated fullerene derivatives are emerging as promising therapeutic drugs for cancer. However, in vivo applications severely limited due cation toxicity. To address this problem, human heavy chain ferritin (HFn), possessing natural biocompatibility is utilized, develop a novel supramolecular assembly drug delivery system. Specifically, tetra[4-(amino)piperidin-1-yl]-C

Язык: Английский

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Integrated oral microgel system ameliorates renal fibrosis by hitchhiking co-delivery and targeted gut flora modulation

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Июнь 1, 2024

Abstract Background Renal fibrosis is a progressive process associated with chronic kidney disease (CKD), contributing to impaired function. Active constituents in traditional Chinese herbs, such as emodin (EMO) and asiatic acid (AA), exhibit potent anti-fibrotic properties. However, the oral administration of EMO AA results low bioavailability limited accumulation. Additionally, while probiotics have been accepted for CKD treatment through gut microbiota modulation, significant challenge lies ensuring their viability upon administration. Therefore, our study aims address both renal imbalance innovative co-delivery strategies. Results In this study, we developed yeast cell wall particles (YCWPs) encapsulating self-assembled nanoparticles (NPYs) embedded them, along Lactobacillus casei Zhang, chitosan/sodium alginate (CS/SA) microgels. The microgels showed controlled release properties loaded NPYs prolonged retention time Zhang ( L. Zhang) intestine. Furthermore, vivo biodistribution that microgel-carried significantly accumulated obstructed kidneys rats, thereby substantially increasing accumulation kidneys. More importantly, hitchhiking delivery based on positive modulation microbiota, synergistic strategy therapeutic modulatory interactions could regulate TGF-β/Smad signaling pathway thus effectively ameliorate unilateral ureteral obstruction (UUO) rats. Conclusion conclusion, work provides new nanodrugs achieve effects targeted flora modulation. Graphical

Язык: Английский

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Metal–organic frameworks as nanoplatforms for combination therapy in cancer treatment

Medical Oncology, Год журнала: 2024, Номер 42(1)

Опубликована: Дек. 9, 2024

Язык: Английский

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