Bladder Cancer, Год журнала: 2023, Номер 9(4), С. 355 - 363
Опубликована: Ноя. 16, 2023
Язык: Английский
Nature Communications, Год журнала: 2023, Номер 14(1)
Опубликована: Дек. 12, 2023
Type-1 and type-3 interferons (IFNs) are important for control of viral replication; however, less is known about the role Type-2 IFN (IFNγ) in anti-viral immunity. We previously observed that lung infection with Mycobacterium bovis BCG achieved though intravenous (iv) administration provides strong protection against SARS-CoV-2 mice yet drives low levels type-1 IFNs but robust IFNγ. Here we examine ongoing IFNγ responses to pre-established bacterial on disease outcomes two murine models. report required iv induced reduction pulmonary loads, an outcome dependent receptor expression by non-hematopoietic cells. Importantly, show prompts epithelial cells upregulate IFN-stimulated genes reported activity IFNγ-dependent manner, suggesting a possible mechanism protection. Finally, confirm properties demonstrating recombinant cytokine itself challenge when administered intranasally. Together, our data response within protective infection, concurrent or recent infections drive may limit pathogenesis supporting prophylactic uses COVID-19 management.
Язык: Английский
Процитировано
28
Clinical Immunology, Год журнала: 2024, Номер 261, С. 109930 - 109930
Опубликована: Фев. 9, 2024
While the efficacy of many current vaccines is well-established, various factors can diminish their effectiveness, particularly in vulnerable groups. Amidst emerging pandemic threats, enhancing vaccine responses critical. Our review synthesizes insights from immunology and epidemiology, focusing on concept trained immunity (TRIM) non-specific effects (NSEs) that confer heterologous protection. We elucidate mechanisms driving TRIM, emphasizing its regulation through metabolic epigenetic reprogramming innate immune cells. Notably, we explore extended protective scope like BCG COVID-19 against unrelated infections, underscoring role reducing neonatal mortality combating diseases malaria yellow fever. also highlight novel strategies to boost efficacy, incorporating TRIM inducers into formulations enhance both specific responses. This approach promises significant advancements development, aiming improve global public health outcomes, especially for elderly immunocompromised populations.
Язык: Английский
Процитировано
10
Pathogens, Год журнала: 2025, Номер 14(1), С. 23 - 23
Опубликована: Янв. 1, 2025
The COVID-19 pandemic has posed a significant threat to global health systems, with extensive impacts across many sectors of society. been responsible for millions deaths worldwide since its first identification in late 2019. Several actions have taken prevent the disease, including unprecedented fast development and vaccination campaigns, which were pivotal reducing symptoms deaths. Given impact pandemic, continuous changes virus, present vaccine technologies, this review analyzes how, so far, we met challenge by emergence new variants discusses how next-generation pan-coronavirus vaccines, enhanced longevity breadth immune responses, may be tackled alternative administration routes antigen delivery platforms. By addressing these critical aspects, aims contribute ongoing efforts achieve long-term control COVID-19, stimulating discussion work on vaccines capable facing future waves infection.
Язык: Английский
Процитировано
2
Pathogens, Год журнала: 2025, Номер 14(2), С. 196 - 196
Опубликована: Фев. 15, 2025
The Bacillus Calmette-Guérin (BCG) vaccine, best known for its role in preventing tuberculosis, has recently garnered attention broader immunomodulatory effects. By inducing trained immunity, BCG reprograms innate immune cells, enhancing their responses to various pathogens. This process, driven by epigenetic and metabolic reprogramming, suggests that may have therapeutic potential far beyond tuberculosis. Emerging evidence points benefits conditions such as autoimmune diseases, cancer, viral infections. Furthermore, modulating activity, been proposed reduce chronic inflammation promote tolerance. review delves into the multifaceted of BCG, highlighting a versatile tool managing wide range diseases.
Язык: Английский
Процитировано
1
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Май 19, 2025
Introduction BCG vaccination can have heterologous or non-specific effects (NSE) that confer resistance against pathogens other than its target Mycobacterium tuberculosis, but the underlying mechanisms are not fully understood. Methods We conducted a systematic review synthesising existing literature on immune mediating heterologous/NSE of BCG. Searches were using MEDLINE and Scopus. Results 1032 original records identified, which 67 deemed eligible. Several potentially relevant pathways although there may be variation by pathogen. Recent studies focused trained immunity whereby innate cells, hematopoietic stem progenitor cells from they derived, undergo epigenetic metabolic reprogramming allowing them to respond more effectively antigen exposures unrelated stimulus. However, processes such as granulopoiesis cross-reactive adaptive also play role. Heterologous NSEs influenced several endogenous exogenous variables. Discussion discuss quality available data, importance understanding protection, implications for strategies. Systematic registration https://www.crd.york.ac.uk/PROSPERO/view/CRD42023400375 , identifier CRD42023400375.
Язык: Английский
Процитировано
1
WIREs Mechanisms of Disease, Год журнала: 2024, Номер 16(4)
Опубликована: Фев. 13, 2024
Abstract Nearly one‐fourth of the global population is infected by Mycobacterium tuberculosis ( Mtb ), and approximately 90%–95% remain asymptomatic as latent infection (LTBI), an estimated 5%–10% those with infections will eventually progress to active (ATB). Although it widely accepted that LTBI transitioning ATB results from a disruption host immune balance weakening protective responses, exact underlying immunological mechanisms promote this conversion are not well characterized. Thus, difficult accurately predict (TB) progression in advance, leaving significant threat TB prevention control. This article systematically explores three aspects related immunoregulatory translational research about LTBI: (1) distinct immunocytological characteristics ATB, (2) diagnostic markers discovery anti‐TB immunity metabolic pathways, (3) vaccine development focus on LTBI. categorized under: Infectious Diseases > Molecular Cellular Physiology Genetics/Genomics/Epigenetics Immune System
Язык: Английский
Процитировано
4
The Journal of Experimental Medicine, Год журнала: 2025, Номер 222(4)
Опубликована: Фев. 28, 2025
BCG is the oldest vaccine in continuous use. While current intradermal vaccination regimens confer limited protection outside context of pediatric extrapulmonary tuberculosis (TB), promising new data indicate that when administered mucosally or intravenously at a higher dose, can induce sterilizing immunity against pulmonary TB nonhuman primates. also known to promote nonspecific host resistance variety unrelated infections and standard immunotherapy for bladder cancer, suggesting this innate immune function may contribute its protective role TB. Here, we propose both mycobacterial-specific off-target effects depend on interplay adaptive cells cytokines they produce, elucidation interaction should be major strategy development more effective BCG-based vaccines immunotherapies.
Язык: Английский
Процитировано
0
Vaccine, Год журнала: 2025, Номер 55, С. 127037 - 127037
Опубликована: Март 21, 2025
Golden Syrian Hamsters are utilized as rodent research models for various bacterial diseases. They highly susceptible to leptospirosis, making hamsters the most common model testing and maintaining virulence of laboratory Leptospira strains well bacterin vaccine efficiency testing. also used modeling features Bacillus Calmette-Guérin (BCG) tuberculosis, they consistently develop granulomas, differing from other BCG animal models. Circulating foamy macrophages have recently been identified in blood following challenge but not controls. It has unknown whether this phenomenon is specific Leptospira/hamster interactions, or will produce circulating response infections. In study, we established that when challenged intraperitoneally with Leptospira. addition macrophages, infected had widespread granuloma formation major organs injection sites which contained resident mineralized bodies, sometimes containing acid fast bacteria.
Язык: Английский
Процитировано
0
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Май 29, 2025
Язык: Английский
Процитировано
0
Reviews in Medical Virology, Год журнала: 2024, Номер 34(1)
Опубликована: Янв. 1, 2024
Abstract Epidemic peaks of respiratory viruses that co‐circulate during the winter‐spring seasons can be synchronous or asynchronous. The occurrence temporal patterns in epidemics caused by some suggests they could negatively interact with each other. These negative interactions may result from a programme innate immune memory, known as trained immunity, which confer broad protective effects against viruses. It is suggested stimulation cells vaccine pathogen induce their long‐term functional reprogramming through an interplay between metabolic and epigenetic changes, influence transcriptional response to secondary challenge. During coronavirus disease 2019 pandemic, circulation most was prevented non‐pharmacological interventions then resumed at unusual periods once sanitary measures were lifted. With time, should find again own ecological niches. This transition period provides opportunity study population level.
Язык: Английский
Процитировано
2