The role of AIM2 in inflammation and tumors DOI Creative Commons

Dalang Yu,

Siping Zheng,

Lina Sui

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Ноя. 12, 2024

Absent in melanoma 2 (AIM2) serves as an intracellular nucleic acid sensor that predominantly detects double-stranded DNA (dsDNA) within the cells. This detection initiates assembly of inflammasome and activates signaling cascade, resulting production inflammatory mediators cleavage Gasdermins. Consequently, these processes culminate responses pyroptotic cell death. AIM2 plays a pivotal role modulating inflammation tumorigenesis, functioning through both inflammasome-dependent independent mechanisms. Its influence on host immune response is dual-faceted, exhibiting promotive inhibitory effects contexts tumors. These are contingent upon specific type expressing nature host’s disease. article seeks to review latest advancements understanding cell-specific functions with objective offering insights for further research informing development targeted therapeutic strategies clinical application.

Язык: Английский

Recent progress of endoplasmic reticulum stress in the mechanism of atherosclerosis DOI Creative Commons
Lin Ni,

Luqun Yang,

Yuanyuan Lin

и другие.

Frontiers in Cardiovascular Medicine, Год журнала: 2024, Номер 11

Опубликована: Июль 12, 2024

The research progress of endoplasmic reticulum (ER) stress in atherosclerosis (AS) is great concern. ER, a critical cellular organelle, plays role important biological processes including protein synthesis, folding, and modification. Various pathological factors may cause ER stress, sustained or excessive triggers the unfolded response, ultimately resulting apoptosis disease. Recently, researchers have discovered importance onset advancement AS. contributes to occurrence AS through different pathways such as apoptosis, inflammatory oxidative autophagy. Therefore, this review focuses on mechanisms development related therapeutic targets, which will contribute deeper understanding disease's pathogenesis provide novel strategies for preventing treating

Язык: Английский

Процитировано

7
Bimetallic peroxide nanoparticles induce PANoptosis by disrupting ion homeostasis for enhanced immunotherapy DOI Creative Commons

Guanghui Hou,

Y.‐J. Chen,

Huali Lei

и другие.

Science Advances, Год журнала: 2024, Номер 10(45)

Опубликована: Ноя. 8, 2024

PANoptosis has recently emerged as a potential approach to improve the immune microenvironment. However, current methods for inducing are limited. Herein, through biological screening, rational use of nutrient metal ions Cu

Язык: Английский

Процитировано

5
PANoptosis: a potential target of atherosclerotic cardiovascular disease DOI Creative Commons

Xiao Jin,

Yanan Zhu,

Lina Xing

и другие.

APOPTOSIS, Год журнала: 2025, Номер unknown

Опубликована: Апрель 26, 2025

Язык: Английский

Процитировано

0
The role of AIM2 in inflammation and tumors DOI Creative Commons

Dalang Yu,

Siping Zheng,

Lina Sui

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Ноя. 12, 2024

Absent in melanoma 2 (AIM2) serves as an intracellular nucleic acid sensor that predominantly detects double-stranded DNA (dsDNA) within the cells. This detection initiates assembly of inflammasome and activates signaling cascade, resulting production inflammatory mediators cleavage Gasdermins. Consequently, these processes culminate responses pyroptotic cell death. AIM2 plays a pivotal role modulating inflammation tumorigenesis, functioning through both inflammasome-dependent independent mechanisms. Its influence on host immune response is dual-faceted, exhibiting promotive inhibitory effects contexts tumors. These are contingent upon specific type expressing nature host’s disease. article seeks to review latest advancements understanding cell-specific functions with objective offering insights for further research informing development targeted therapeutic strategies clinical application.

Язык: Английский

Процитировано

1