A Better Understanding of the Clinical and Pathological Changes in Viral Retinitis: Steps to Improve Visual Outcomes DOI Creative Commons
Nghi M. Nguyen, Christopher D. Conrady

Microorganisms, Год журнала: 2024, Номер 12(12), С. 2513 - 2513

Опубликована: Дек. 5, 2024

Infectious retinitis, though rare, poses a significant threat to vision, often leading severe and irreversible damage. Various pathogens, including viruses, bacteria, tick-borne agents, parasites, fungi, can cause this condition. Among these, necrotizing herpetic retinitis represents critical spectrum of retinal infections primarily caused by herpes viruses such as varicella-zoster virus (VZV), simplex (HSV), cytomegalovirus (CMV). This review underscores the retina’s susceptibility viral infections, focusing on molecular mechanisms through which invade damage tissue, supported clinical preclinical evidence. We also identify existing knowledge gaps propose future research directions deepen our understanding improve therapeutic outcomes.

Язык: Английский

IRF1 amplifies HSV-1-triggered antiviral innate immunity in a feed-forward manner DOI Creative Commons
Ming Gao, Yingjun Qi, Junjie Zhang

и другие.

Cell Insight, Год журнала: 2025, Номер unknown, С. 100255 - 100255

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Herpes simplex virus 1 evades APOBEC1-mediated immunity via its uracil-DNA glycosylase in mice DOI
Akihisa Kato, Hayato Harima,

Yuji Tsunekawa

и другие.

Nature Microbiology, Год журнала: 2025, Номер unknown

Опубликована: Июнь 3, 2025

Язык: Английский

Процитировано

0
RNA Modifications in Pathogenic Viruses: Existence, Mechanism, and Impacts DOI Creative Commons
Yongjin Zou,

Zijun Guo,

Xing‐Yi Ge

и другие.

Microorganisms, Год журнала: 2024, Номер 12(11), С. 2373 - 2373

Опубликована: Ноя. 20, 2024

RNA modification is a key posttranscriptional process playing various biological roles, and one which has been reported to exist extensively in cellular RNAs. Interestingly, recent studies have shown that viral RNAs also contain variety of modifications, are regulated dynamically by host machinery play critical roles different stages the life cycle. In this review, we summarize reports four typical modifications on RNAs, including N6-methyladenosine (m6A), 5-methylcytosine (m5C), N4-acetylcytosine (ac4C), N1-methyladenosine (m1A), describe molecular mechanisms these processes, illustrate their impacts replication, pathogenicity, innate immune responses. Notably, find viruses share some common features generation, regulation, function, highlighting potential for related serve as targets or bases development antiviral therapeutics vaccines.

Язык: Английский

Процитировано

2
A Better Understanding of the Clinical and Pathological Changes in Viral Retinitis: Steps to Improve Visual Outcomes DOI Creative Commons
Nghi M. Nguyen, Christopher D. Conrady

Microorganisms, Год журнала: 2024, Номер 12(12), С. 2513 - 2513

Опубликована: Дек. 5, 2024

Infectious retinitis, though rare, poses a significant threat to vision, often leading severe and irreversible damage. Various pathogens, including viruses, bacteria, tick-borne agents, parasites, fungi, can cause this condition. Among these, necrotizing herpetic retinitis represents critical spectrum of retinal infections primarily caused by herpes viruses such as varicella-zoster virus (VZV), simplex (HSV), cytomegalovirus (CMV). This review underscores the retina’s susceptibility viral infections, focusing on molecular mechanisms through which invade damage tissue, supported clinical preclinical evidence. We also identify existing knowledge gaps propose future research directions deepen our understanding improve therapeutic outcomes.

Язык: Английский

Процитировано

0