Rheumatology Science and Practice,
Год журнала:
2024,
Номер
62(5), С. 445 - 464
Опубликована: Окт. 31, 2024
The
main
indications
for
colchicine
treatment
until
recently
were
gout,
pericarditis,
familial
Mediterranean
fever
and
some
other
auto-inflammatory
diseases.
expansion
of
(repositioning)
the
use
in
direction
prevention
cardiovascular
complications
should
be
considered
as
one
major
events
medicine
XXI
century.
Deciphering
role
inflammation
most
important
mechanism
development
atherosclerosis
has
created
prerequisites
concept
anti-inflammatory
therapy
atherosclerosis,
which
low-dose
can
take
an
place,
complementing
effects
aspirin,
statins
antihypertensive
therapy.
analysis
materials
from
randomized
placebo-controlled
studies
indicates
a
decrease
frequency
patients
with
coronary
heart
disease
(by
31%)
who
have
suffered
myocardial
infarction
23%),
well
33%),
stroke,
need
revascularization
mortality.
low
dose
(0.5
mg/day)
is
approved
by
U.S.
Food
Drug
Administration
disease.
It
assumed
that
future
will
place
pathology
associated
atherosclerotic
vascular
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Сен. 11, 2023
Venous
thromboembolism
(VTE)
is
a
leading
cause
of
preventable
deaths
in
hospitals,
and
its
incidence
not
decreasing
despite
extensive
efforts
clinical
laboratory
research.
thrombi
are
primarily
formed
the
valve
pockets
deep
veins,
where
activated
monocytes
play
crucial
role
bridging
innate
immune
activation
hemostatic
pathways
through
production
inflammatory
cytokines,
chemokines,
tissue
factor
(TF)
–
principal
initiator
coagulation.
In
pocket
inflammation
hypoxia
(sustained/intermittent)
coexist,
however
their
combined
effects
on
immunothrombotic
processes
poorly
understood.
Inflammation
strongly
associated
with
VTE,
while
additional
contribution
remains
largely
unexplored.
To
investigate
this,
we
modelled
intricate
conditions
venous
using
state-of-the-art
chamber
software-controlled
oxygen
cycling.
We
comprehensively
studied
sustained
intermittent
alone,
combination
VTE-associated
stimuli
primary
monocytes.
TF
expression
activity
was
measured
subjected
to
or
IL-1β.
Monocyte
responses
were
further
analyzed
detailed
by
RNA
sequencing
validated
ELISA.
Stimulation
IL-1β
alone
promoted
both
transcription
TF.
Interestingly,
stimulatory
effect
attenuated
hypoxia,
but
hypoxia.
Our
transcriptome
analysis
confirmed
that
limited
pro-inflammatory
response
induced
IL-1β,
triggered
metabolic
shift
Intermittent
had
modest
monocyte
transcript.
However,
significantly
altered
2207
genes
enhanced
IL-1β-stimulatory
several
chemokine
interleukin
(e.g.,
IL-19,
IL-24,
IL-32,
MIF),
as
well
involved
coagulation
(thrombomodulin)
fibrinolysis
(VEGFA,
MMP9,
MMP14
PAI-1).
Increased
CCL2,
IL-6
TNF
following
stimulation
findings
provide
valuable
insights
into
how
different
hypoxic
profiles
shape
shed
new
light
early
events
pathogenesis
thrombosis.
Rheumatology Science and Practice,
Год журнала:
2024,
Номер
62(5), С. 445 - 464
Опубликована: Окт. 31, 2024
The
main
indications
for
colchicine
treatment
until
recently
were
gout,
pericarditis,
familial
Mediterranean
fever
and
some
other
auto-inflammatory
diseases.
expansion
of
(repositioning)
the
use
in
direction
prevention
cardiovascular
complications
should
be
considered
as
one
major
events
medicine
XXI
century.
Deciphering
role
inflammation
most
important
mechanism
development
atherosclerosis
has
created
prerequisites
concept
anti-inflammatory
therapy
atherosclerosis,
which
low-dose
can
take
an
place,
complementing
effects
aspirin,
statins
antihypertensive
therapy.
analysis
materials
from
randomized
placebo-controlled
studies
indicates
a
decrease
frequency
patients
with
coronary
heart
disease
(by
31%)
who
have
suffered
myocardial
infarction
23%),
well
33%),
stroke,
need
revascularization
mortality.
low
dose
(0.5
mg/day)
is
approved
by
U.S.
Food
Drug
Administration
disease.
It
assumed
that
future
will
place
pathology
associated
atherosclerotic
vascular
