Acupuncture attenuates myocardial ischemia/reperfusion injury-induced ferroptosis via the Nrf2/HO-1 pathway

Chinese Medicine, Год журнала: 2025, Номер 20(1)

Опубликована: Май 9, 2025

Abstract Aims To observe the effect of electro-acupuncture (EA) on cardiomyocytes ferroptosis induced by myocardial ischemia/reperfusion injury (MIRI) in mice and to investigate whether this occurs via nuclear factor-E2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) signalling pathway. Materials methods Firstly, Fe 2+ hearts serum from both sham-operated (SO) group MIRI was measured ascertain had occurred group. In second phase, EA administered, with sham acupuncture (SA) as comparator, protective effects cardiac function. Additionally, we studied levels Nrf2 HO-1 within myocardium. third inhibitor ML385 agonist DMF were applied impact inhibiting therapeutic efficacy EA. Results Compared SO group, showed increased iron deposition, along a significant decrease levels. + exhibited significantly improved function reduced accompanied Furthermore, superior that SA Administration partially blocked anti-ferroptotic cardioprotective EA, while treatment similar dimethyl fumarate (DMF) intervention. Conclusion alleviates ferroptosis-induced damage Nrf2/HO-1 pathway, providing modern scientific evidence for application cardiovascular diseases.

Язык: Английский

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Interfering with AQP1 alleviates ferroptosis, improves mitochondrial function and energy metabolic disorder in hypoxia/reoxygenation-induced H9c2 cardiomyocytes via Wnt/β-catenin pathway

Microvascular Research, Год журнала: 2025, Номер unknown, С. 104821 - 104821

Опубликована: Май 1, 2025

Язык: Английский

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Cardiomyocyte mitochondria targeted biomimetic nanozyme system with calcium ion chelating agent to treat myocardial ischemia–reperfusion injury model in mice

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 164177 - 164177

Опубликована: Май 1, 2025

Язык: Английский

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A novel ultrasound-triggered cardiac patch for targeted nitric oxide delivery to promote angiogenesis and reduce inflammation for the treatment of myocardial infarction

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 164172 - 164172

Опубликована: Май 1, 2025

Язык: Английский

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Hydroxysafflor yellow A alleviates ischemic myocardial injury by targeting SF3A1 to improve mitochondrial energy metabolism

European Journal of Pharmacology, Год журнала: 2025, Номер unknown, С. 177789 - 177789

Опубликована: Май 1, 2025

Язык: Английский

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