Peptide amphiphiles alleviate myocardial endoplasmic reticulum stress to enhance cardiomyocyte–macrophage communication and promote macrophage M2 polarization DOI
Wenjie Guo,

Hui-Ming Chen,

Fengjiao Liu

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 378, P. 719 - 734

Published: Dec. 28, 2024

Language: Английский

The cGAS-STING Pathway: A New Therapeutic Target for Ischemia–Reperfusion Injury in Acute Myocardial Infarction? DOI Creative Commons

Mengxiang Tian,

Fengyuan Li,

Haiping Pei

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1728 - 1728

Published: Aug. 2, 2024

The innate immune system is the body's natural defense system, which recognizes a wide range of microbial molecules (such as bacterial DNA and RNA) abnormal within cells misplaced DNA, self-antigens) to play its role. released into cytoplasm activates cyclic GMP-AMP synthase (cGAS)-stimulator interferon genes (STING) signaling pathway initiate an response. Ischemia-reperfusion injury (IRI) after acute myocardial infarction refers phenomenon where tissue suffers further damage upon restoration blood flow. This issue significant clinical problem in treatment infarction, it can diminish effectiveness reperfusion therapy lead deterioration cardiac function. Studies have found that cGAS-STING closely related this phenomenon. Therefore, review aims describe role ischemia-reperfusion summarize current development status inhibitors application nanomaterials elucidate potential therapeutic target.

Language: Английский

Citations

2
Verapamil attenuates myocardial ischemia/reperfusion injury by inhibiting apoptosis via activating the JAK2/STAT3 signaling pathway DOI Open Access
Yang Zhao, Weiyi Huang, Fang Liu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 180, P. 117568 - 117568

Published: Oct. 13, 2024

Language: Английский

Citations

1
SCAI Expert Consensus Statement on the Management of Patients With STEMI Referred for Primary PCI DOI Creative Commons
Jacqueline E. Tamis‐Holland, J. Dawn Abbott, Karim Al‐Azizi

et al.

Journal of the Society for Cardiovascular Angiography & Interventions, Journal Year: 2024, Volume and Issue: 3(11), P. 102294 - 102294

Published: Oct. 7, 2024

ST-elevation myocardial infarction (STEMI) remains a leading cause of morbidity and mortality in the United States. Timely reperfusion with primary percutaneous coronary intervention is associated improved outcomes. The Society for Cardiovascular Angiography & Interventions puts forth this expert consensus document regarding best practices cardiac catheterization laboratory team readiness, arterial access an algorithm to help determine proper STEMI, diagnostic angiography. This statement highlights strengths limitations various therapeutic interventions treat patient STEMI laboratory, reviews different options manage large thrombus burden during management across spectrum anatomical clinical circumstances.

Language: Английский

Citations

1
Inflammation and ischemia-reperfusion injury in STEMI DOI
Ivan Lechner, Martin Reindl,

Bernhard Metzler

et al.

International Journal of Cardiology, Journal Year: 2024, Volume and Issue: unknown, P. 132760 - 132760

Published: Nov. 1, 2024

Language: Английский

Citations

1
Peptide amphiphiles alleviate myocardial endoplasmic reticulum stress to enhance cardiomyocyte–macrophage communication and promote macrophage M2 polarization DOI
Wenjie Guo,

Hui-Ming Chen,

Fengjiao Liu

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 378, P. 719 - 734

Published: Dec. 28, 2024

Language: Английский

Citations

1