Where Microneedle Meets Biomarkers: Futuristic Application for Diagnosing and Monitoring Localized External Organ Diseases

Advanced Healthcare Materials, Год журнала: 2022, Номер 12(5)

Опубликована: Ноя. 22, 2022

Extracellular tissue fluids are interesting biomatrices that have recently attracted scientists' interest. Many significant biomarkers for localized external organ diseases been isolated from this biofluid. In the diagnostic and disease monitoring context, measuring biochemical entities surrounding diseased tissues may give more important clinical value than them at a systemic level. Despite all these facts, pushing fluid-based diagnosis forward to settings faces one major problem: its accessibility. Most extracellular fluid, such as interstitial fluid (ISF), is abundant but hard collect, currently available technologies invasive expensive. This where novel microneedle technology can help tackle obstacle. The ability of minimally invasively access fluid-containing will enable ISF other utilization in diseases. review attempts present current pursuit application systems platform, along with recent progress biomarker detection diagnosing Then, potential use various microneedles future diagnostics discussed by presenting studied cases.

Язык: Английский

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Immunopathogenesis of Atopic Dermatitis: Focus on Interleukins as Disease Drivers and Therapeutic Targets for Novel Treatments

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(1), С. 781 - 781

Опубликована: Янв. 2, 2023

Atopic dermatitis is a chronic, recurrent inflammatory skin disorder manifesting by eczematous lesions and intense pruritus. develops primarily as result of an epidermal barrier defect immunological imbalance. Advances in understanding these pathogenetic hallmarks, particularly the complex role interleukins atopic drivers, resulted achieving significant therapeutic breakthroughs. Novel medications involve monoclonal antibodies specifically blocking function selected small molecules such Janus kinase inhibitors limiting downstream signaling to reduce expression wider array proinflammatory factors. Nevertheless, subset patients remains refractory those treatments, highlighting complexity immunopathogenesis different populations. In this review, we address heterogeneity endotypes phenotypes present novel interleukin-oriented therapies for disease.

Язык: Английский

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Efficacy of Bifidobacterium longum alone or in multi-strain probiotic formulations during early life and beyond

Gut Microbes, Год журнала: 2023, Номер 15(1)

Опубликована: Март 10, 2023

The significance of Bifidobacterium to human health can be appreciated from its early colonization the neonatal gut, where longum represents most abundant species. While relative abundance declines with age, it is further reduced in several diseases. Research into beneficial properties B. has unveiled a range mechanisms, including production bioactive molecules, such as short-chain fatty acids, polysaccharides, and serine protease inhibitors. From intestinal niche, have far-reaching effects body influencing immune responses lungs even skin, well brain activity. In this review, we present biological clinical impacts species on conditions beginning life beyond. available scientific evidence reveals strong rationale for continued research trials that investigate ability treat or prevent diseases across lifespan.

Язык: Английский

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Serum biomarker-based endotypes of atopic dermatitis in China and prediction for efficacy of dupilumab

British Journal of Dermatology, Год журнала: 2023, Номер 188(5), С. 649 - 660

Опубликована: Фев. 9, 2023

Abstract Background Atopic dermatitis (AD) is a highly heterogeneous disease clinically and biologically. Serum biomarkers have been utilized for endotype identification the potential to be predictors treatment. Objectives To explore serum biomarker-based endotypes of Chinese patients with AD identify prediction efficacy dupilumab. Methods Sera from 125 moderate-to-severe 60 normal controls (NC) were analysed 24 cytokines/chemokines using magnetic Luminex assay. After received 16 weeks dupilumab treatment, was evaluated, blood eosinophils, immunoglobulin (Ig) E measured. Results characterized by T-helper (Th)2-dominant that mixed differentially increased Th1-, Th17- Th22-type cytokines/chemokines, it mainly Th2-type positively correlated severity eosinophil counts. Adult (but not adolescent or elderly) showed consistent more significant increase across different types inflammation. The grouped into two clusters unsupervised k-means analysis, which associated Treatment decreased levels most analysed. While there no difference between in dupilumab, baseline CD25/soluble interleukin (sIL)-2Rα, IL-31 IL-36β identified as predictive factors efficacy. Conclusions Our study revealed inflammation-related based on biomarkers. High CD25/sIL-2Rα, might predict good

Язык: Английский

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Single-cell RNA sequencing defines disease-specific differences between chronic nodular prurigo and atopic dermatitis

Journal of Allergy and Clinical Immunology, Год журнала: 2023, Номер 152(2), С. 420 - 435

Опубликована: Май 18, 2023

Язык: Английский

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