Biological Procedures Online,
Год журнала:
2024,
Номер
26(1)
Опубликована: Дек. 19, 2024
Chang-Wei-Qing
(CWQ)
is
a
widely
recognized
Traditional
Chinese
Medicine
(TCM)
formulation
composed
of
Astragalus,
Codonopsis,
Atractylodes,
Poria,
Coix
seed,
Akebia
trifoliata
Koidz,
Sargentodoxa
cuneata,
and
Vitis
quinquangularis
Rehd.
This
has
garnered
significant
interest
for
its
positive
effects
in
mitigating
colorectal
cancer,
when
combined
with
PD-1,
it
affects
some
gut
microbiota
associated
tumor
infiltrating
lymphocytes
cells.
However,
the
biological
rationale
underlying
suppression
colitis-associated
cancer
(CAC)
AOM/DSS-treated
mice
by
CWQ
PD-1
inhibitor
remains
to
be
explored.
Our
aim
explore
chemopreventive
effect
on
CAC,
focus
modulating
microbiota.
A
mouse
model
CAC
was
established
using
azoxymethane
(AOM)
dextran
sulfate
sodium
(DSS)
treatment.
Pathological
evaluation
tissue
samples
included
immunohistochemistry
hematoxylin
eosin
staining.
Intestinal
barrier
function
assessed
transmission
electron
microscopy.
Fecal
metabolites
were
analyzed
through
16
S
rRNA
gene
sequencing
liquid
chromatography-mass
spectrometry,
respectively.
Mice
treated
antibiotics
served
as
models
fecal
transplantation.
suppressed
mice.
therapy
effectively
alleviated
dysbiosis
increasing
microbial
diversity,
enriching
probiotic
populations
such
Limosilactobacillus
Bifidobacterium,
reducing
pathogenic
bacteria
like
Desulfovibrio.
Additionally,
downregulated
NF-kappa
B
signaling
pathway.
The
treatment
also
significantly
improved
intestinal
Transmission
microscopy
group
showed
enhanced
cellular
integrity,
relatively
normal
mitochondrial
structure
intact
membranes,
more
abundant,
unexpanded
endoplasmic
reticulum,
underscoring
protective
this
combination
integrity.
Transcriptomic
analysis
further
demonstrated
that
upregulated
genes
involved
tight
adherens
junctions,
while
downregulating
linked
innate
immune
responses.
can
ameliorate
AOM/DSS
model,
microbiome
potentially
possessing
anti-inflammatory
activity.
Moreover,
improves
function,
thereby
inhibiting
occurrence
development
CAC.
Abstract
Previous
studies
have
shown
a
bidirectional
communication
between
human
gut
microbiota
and
the
brain,
known
as
microbiota–gut–brain
axis
(MGBA).
The
MGBA
influences
host's
nervous
system
development,
emotional
regulation,
cognitive
function
through
neurotransmitters,
immune
modulation,
metabolic
pathways.
Factors
like
diet,
lifestyle,
genetics,
environment
shape
composition
together.
Most
research
explored
how
regulates
host
physiology
its
potential
in
preventing
treating
neurological
disorders.
However,
individual
heterogeneity
of
microbiota,
strains
playing
dominant
role
diseases,
interactions
these
microbial
metabolites
with
central/peripheral
systems
still
need
exploration.
This
review
summarizes
driving
neurodevelopmental
disorders
(autism
spectrum
disorder
attention
deficit/hyperactivity
disorder),
neurodegenerative
diseases
(Alzheimer's
Parkinson's
disease),
mood
(anxiety
depression)
recent
years
discusses
current
clinical
preclinical
microbe‐based
interventions,
including
dietary
intervention,
probiotics,
prebiotics,
fecal
transplantation.
It
also
puts
forward
insufficient
on
provides
framework
for
further
Cellular and Molecular Neurobiology,
Год журнала:
2024,
Номер
44(1)
Опубликована: Окт. 8, 2024
The
increasing
prevalence
of
neurological
disorders
such
as
Alzheimer's,
Parkinson's,
and
multiple
sclerosis
presents
a
significant
global
health
challenge.
Despite
extensive
research,
the
precise
mechanisms
underlying
these
conditions
remain
elusive,
with
current
treatments
primarily
addressing
symptoms
rather
than
root
causes.
Emerging
evidence
suggests
that
gut
permeability
kynurenine
pathway
are
involved
in
pathogenesis
conditions,
offering
promising
targets
for
novel
therapeutic
preventive
strategies.
Gut
refers
to
intestinal
lining's
ability
selectively
allow
essential
nutrients
into
bloodstream
while
blocking
harmful
substances.
Various
factors,
including
poor
diet,
stress,
infections,
genetic
predispositions,
can
compromise
integrity,
leading
increased
permeability.
This
condition
facilitates
translocation
toxins
bacteria
systemic
circulation,
triggering
widespread
inflammation
impacts
via
gut-brain
axis.
axis
(GBA)
is
complex
communication
network
between
central
nervous
system.
Dysbiosis,
an
imbalance
microbiota,
increase
inflammation,
exacerbating
neuroinflammation-a
key
factor
disorders.
pathway,
primary
route
tryptophan
metabolism,
significantly
implicated
this
process.
Dysregulation
context
leads
production
neurotoxic
metabolites,
quinolinic
acid,
which
contribute
neuronal
damage
progression
narrative
review
highlights
potential
progress
understanding
mechanisms.
Interventions
targeting
maintaining
balanced
microbiota
through
probiotics,
lifestyle
modifications
show
promise
reducing
neuroinflammation
supporting
brain
health.
In
addition,
pharmacological
approaches
aimed
at
modulating
directly,
inhibitors
indoleamine
2,3-dioxygenase,
offer
avenues
new
treatments.
Understanding
interconnected
pathways
crucial
developing
effective
strategies
prevent
manage
Nutrients,
Год журнала:
2024,
Номер
16(8), С. 1134 - 1134
Опубликована: Апрель 11, 2024
Human
milk
promotes
the
growth
of
bifidobacteria
in
infant
gut.
Adding
bifidobacterial
species
to
formula
may
contribute
increasing
their
presence
gut
formula-fed
infants.
Therefore,
safety
and
anti-infectious
effects
Bifidobacterium
breve
DSM32583,
a
breast
isolate,
were
assessed
pilot
trial
involving
3-month-old
The
infants
randomly
assigned
either
probiotic
(PG)
or
control
(CG)
groups.
All
consumed
same
formula,
although
it
was
supplemented
with
strain
(1
×
107
cfu/g
formula)
PG.
Overall,
160
(80
per
group)
finished
intervention.
Infants
CG
gained
more
weight
compared
PG
(p
<
0.05),
but
weights
for
age
Z-scores
at
6
months
within
normal
distribution
this
group.
rates
infections
affecting
gastrointestinal
respiratory
tracts
antibiotic
therapy
significantly
lower
population
level
short-chain
fatty
acids
higher
0.05)
fecal
samples
No
adverse
events
related
consumption
observed.
In
conclusion,
administration
an
B.
DSM32583
safe
exerted
potential
beneficial
on
health.
Food & Function,
Год журнала:
2024,
Номер
15(7), С. 3653 - 3668
Опубликована: Янв. 1, 2024
Pretreatment
with
Bifidobacterium
longum
GL001
alleviates
inflammation
and
oxidative
stress
damage
induced
by
IIR
in
rats,
improves
the
gut
microbiota
intestinal
tissue
metabolism
rats.
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(50), С. 27679 - 27700
Опубликована: Ноя. 26, 2024
The
burgeoning
field
of
microbiome
research
has
profoundly
reshaped
our
comprehension
human
health,
particularly
highlighting
the
potential
probiotics
and
fecal
microbiota
transplantation
(FMT)
as
therapeutic
interventions.
While
benefits
traditional
are
well-recognized,
efficacy
mechanisms
remain
ambiguous,
FMT's
long-term
effects
still
being
investigated.
Recent
advancements
in
high-throughput
sequencing
have
identified
gut
microbes
with
significant
health
benefits,
paving
way
for
next-generation
(NGPs).
These
NGPs,
engineered
through
synthetic
biology
bioinformatics,
designed
to
address
specific
disease
states
enhanced
stability
viability.
This
review
synthesizes
current
on
NGP
stability,
challenges
delivery,
their
applications
preventing
treating
chronic
diseases
such
diabetes,
obesity,
cardiovascular
diseases.
We
explore
physiological
characteristics,
safety
profiles,
action
various
strains
while
also
addressing
opportunities
presented
by
integration
into
clinical
practice.
NGPs
revolutionize
microbiome-based
therapies
improve
outcomes
is
immense,
underscoring
need
further
optimize
ensure
safety.
