Epithelial barrier hypothesis: Effect of the external exposome on the microbiome and epithelial barriers in allergic disease

Allergy, Год журнала: 2022, Номер 77(5), С. 1418 - 1449

Опубликована: Фев. 2, 2022

Environmental exposure plays a major role in the development of allergic diseases. The exposome can be classified into internal (e.g., aging, hormones, and metabolic processes), specific external chemical pollutants or lifestyle factors), general broader socioeconomic psychological contexts) domains, all which are interrelated. All factors we exposed to, from moment conception to death, part exposome. Several hundreds thousands new chemicals have been introduced modern life without our having full understanding their toxic health effects ways mitigate these effects. Climate change, air pollution, microplastics, tobacco smoke, changes loss biodiversity, alterations dietary habits, microbiome due modernization, urbanization, globalization constitute surrounding environment Some disrupt epithelial barriers skin mucosal surfaces, disruptions linked last few decades increasing prevalence severity inflammatory diseases such as atopic dermatitis, food allergy, rhinitis, chronic rhinosinusitis, eosinophilic esophagitis, asthma. barrier hypothesis provides mechanistic explanation how explain rapid increase autoimmune In this review, discuss affecting planet's context 'epithelial hypothesis,' including climate emphasize on addition, roles increased fatty acid consumption environmental substances (detergents, airborne pollen, ozone, nanoparticles, tobacco) discussed. Considering emerging data recent studies, suggest stringent governmental regulations, global policy adjustments, patient education, establishment individualized control measures threats decrease disease.

Язык: Английский

---

Immune-mediated disease caused by climate change-associated environmental hazards: mitigation and adaptation

Frontiers in Science, Год журнала: 2024, Номер 2

Опубликована: Апрель 4, 2024

Global warming and climate change have increased the pollen burden frequency intensity of wildfires, sand dust storms, thunderstorms, heatwaves—with concomitant increases in air pollution, heat stress, flooding. These environmental stressors alter human exposome trigger complex immune responses. In parallel, pollutants, allergens, other factors increase risks skin mucosal barrier disruption microbial dysbiosis, while a loss biodiversity reduced exposure to diversity impairs tolerogenic development. The resulting dysregulation is contributing an immune-mediated diseases such as asthma allergic diseases, autoimmune cancer. It now abundantly clear that multisectoral, multidisciplinary, transborder efforts based on Planetary Health One approaches (which consider dependence health environment natural ecosystems) are urgently needed adapt mitigate effects change. Key actions include reducing emissions improving quality (through fossil fuel use), providing safe housing (e.g., weatherization), diets (i.e., diversity) agricultural practices, increasing green spaces. There also pressing need for collaborative, multidisciplinary research better understand pathophysiology context New data science techniques, biomarkers, economic models should be used measure impact disease, inform mitigation adaptation efforts, evaluate their effectiveness. Justice, equity, diversity, inclusion (JEDI) considerations integral these address disparities

Язык: Английский

---

Climate change and allergies

Allergo Journal International, Год журнала: 2022, Номер 31(4), С. 114 - 120

Опубликована: Июнь 1, 2022

Abstract The climate crisis poses a major challenge to human health as well the healthcare system and threatens jeopardize medical progress made in recent decades. However, addressing change may also be greatest opportunity for global 21st century. its consequences, such rising temperatures, forest fires, floods, droughts, changes quality quantity of food water, directly indirectly affect physical mental health. More intense frequent heat waves declining air have been shown increase all-cause mortality, especially among most vulnerable. Climate warming alters existing ecosystems favors biological invasions by species that better tolerate drought. Pathogen profiles are changing, transmission spread vector-borne diseases increasing. neophytes Europe, ragweed, is creating new pollen sources allergen exposure allergy sufferers. In addition, overall milder weather, combination with pollution increased CO 2 levels, changing production allergenicity pollen. phenomenon thunderstorm asthma occurring more frequently. view increasing prevalence allergic due change, early causal immunomodulatory therapy therefore all important. During consultation, patients can receive individual advice on adaptation resilience benefits reduction—for their own planet’s Almost 5% greenhouse gas emissions Europe come from sector. It thus has central responsibility climate-neutral sustainable transformation.

Язык: Английский

---

Pollen season trends as markers of climate change impact: Betula, Quercus and Poaceae

The Science of The Total Environment, Год журнала: 2022, Номер 831, С. 154882 - 154882

Опубликована: Март 29, 2022

The incidences of respiratory allergies are at an all-time high. Pollen aeroallergens can reflect changing climate, with recent studies in Europe showing some, but not all, pollen types increasing severity, season duration and experiencing earlier onset. This study aimed to identify trends the UK over last twenty-six years for a range sites, focus on key Poaceae (grass), Betula (birch) Quercus (oak) examine relationship these meteorological factors. seasons show no significant onset, first high day or production Midlands region is being driven by warmer temperatures previous June July. starting earlier, due temperature sunshine totals April, becoming more severe. lasting longer, although climate drivers this were identified. occurring central regions trend all variables December, January, May June. Severity spatially temporally variable. Important changes that will impact health allergy sufferers, severe longer seasons. Most identified caused total. However, neither nor longer. reasons included lack change some monthly variables, land-use change, such as grassland replaced urban areas woodland.

Язык: Английский

---

Public Health Implications of Drought in a Climate Change Context: A Critical Review

Annual Review of Public Health, Год журнала: 2023, Номер 44(1), С. 213 - 232

Опубликована: Янв. 10, 2023

Extreme weather events are expected to increase due climate change, which could pose an additional burden of morbidity and mortality. In recent decades, drought severity has increased in several regions around the world, affecting health by increasing risk water-, food-, vector-borne diseases, malnutrition, cardiovascular respiratory illness, mental disorders, Drought frequency worsen across large as a result decrease precipitation temperature atmospheric evaporative demand, posing pressing challenge for public health. Variation impacts among countries communities is multiple factors, such aging, socioeconomic status, access care, gender, population resilience. Integrative proactive action plans focused on management required, resources should be transferred developing reduce their vulnerability risk.

Язык: Английский

---

TFOS Lifestyle: Impact of contact lenses on the ocular surface

The Ocular Surface, Год журнала: 2023, Номер 29, С. 175 - 219

Опубликована: Май 4, 2023

Язык: Английский

---

Understanding the connections between climate change, air pollution, and human health in Africa: Insights from a literature review

Journal of Environmental Science and Health Part C, Год журнала: 2023, Номер 41(3-4), С. 77 - 120

Опубликована: Окт. 2, 2023

Climate change and air pollution are two interconnected global challenges that have profound impacts on human health. In Africa, a continent known for its rich biodiversity diverse ecosystems, the adverse effects of climate particularly concerning. This review study examines implications health well-being in Africa. It explores intersection these factors their impact various outcomes, including cardiovascular disease, respiratory disorders, mental health, vulnerable populations such as children elderly. The highlights disproportionate groups emphasizes need targeted interventions policies to protect Furthermore, it discusses role exacerbating potential long-term consequences public also addresses importance considering temperature precipitation changes modifiers pollution. By synthesizing existing research, this aims shed light complex relationships highlight key findings, knowledge gaps, solutions mitigating region. insights gained from can inform evidence-based mitigate promote sustainable development

Язык: Английский

---

Is exposure to pollen a risk factor for moderate and severe asthma exacerbations?

Allergy, Год журнала: 2023, Номер 78(8), С. 2121 - 2147

Опубликована: Март 24, 2023

Limited number of studies have focused on the impact pollen exposure asthma. As a part EAACI Guidelines Environment Science, this first systematic review relationship to asthma exacerbations aimed bridge knowledge gap in view implementing recommendations prevention. We searched electronic iPubMed, Embase, and Web Science databases using set MeSH terms related synonyms identified 73 eligible that were included for systemic review. When possible, meta-analyses conducted. Overall meta-analysis suggests outdoor may an effect exacerbation, but caution is needed due low their heterogeneity. The strongest associations found between attacks, asthma-related ED admissions or hospitalizations, increase grass concentration previous 2-day overall children aged less than 18 years age. Tree visits lagged up 7-day individuals younger years. Rare data show among subjects under age, 3 days lower lung function. Further research considering modifiers sensitization, hay fever, asthma, air pollution, green spaces, pre-existing medications urgently warranted better evaluate impacts exacerbation. Preventive measures relation should be integrated control as continues climate change.

Язык: Английский

---

Climate change and respiratory health: a European Respiratory Society position statement

European Respiratory Journal, Год журнала: 2023, Номер 62(2), С. 2201960 - 2201960

Опубликована: Авг. 1, 2023

Tweetable abstract

Climate change is a major threat to lung patients, causing more frequent and extreme weather events, prolonged aeroallergen seasons, poorer air quality. ERS calls on the health community policymakers act now prepare for complex future.https://bit.ly/3pO27Ne

Язык: Английский

---

Global warming and implications for epithelial barrier disruption and respiratory and dermatologic allergic diseases

Journal of Allergy and Clinical Immunology, Год журнала: 2023, Номер 152(5), С. 1033 - 1046

Опубликована: Сен. 9, 2023

Язык: Английский

---