From heart to gut: Exploring the gut microbiome in congenital heart disease DOI Creative Commons
Yuze Liu, Yuan Huang, Qiyu He

и другие.

iMeta, Год журнала: 2023, Номер 2(4)

Опубликована: Окт. 30, 2023

Abstract Congenital heart disease (CHD) is a prevalent birth defect and significant contributor to childhood mortality. The major characteristics of CHD include cardiovascular malformations hemodynamical disorders. However, the impact extends beyond circulatory system. Evidence has identified dysbiosis gut microbiome in patients with CHD. Chronic hypoxia inflammation associated affect microbiome, leading alterations its number, abundance, composition. aside from providing essential nutrients, engages direct interactions host immune system indirect via metabolites. abnormal or products can translocate into bloodstream through an impaired barrier, inflammatory state. Metabolites such as short‐chain fatty acids trimethylamine N ‐oxide, also play important roles development, treatment, prognosis This review discusses role immunity, neurodevelopment, perioperative period By fostering better understanding cross‐talk between this aims contribute improve clinical management outcomes for patients.

Язык: Английский

Cognitive and behavioral benefits of 2′-fucosyllactose in growing mice: the roles of 5-hydroxytryptophan and gut microbiota DOI Creative Commons

Liuying Zhu,

Zhiyi Zhang, Ting Luo

и другие.

Microbiome, Год журнала: 2025, Номер 13(1)

Опубликована: Апрель 12, 2025

2'-Fucosyllactose (2'-FL) is one of the major oligosaccharides found in human breast milk, with several recognized beneficial effects on host. Extensive research has indicated positive 2'-FL cognitive development brain, yet its molecular mechanisms have remained elusive. This study aimed to assess impact gut-brain axis microbiota and function growing mice, along potential action. Following long-term supplementation for 4 weeks, was enhance memory mice (3 weeks old) as assessed through Y-maze, novel object recognition, water maze tests. Analysis via 16S rRNA sequencing revealed significant alterations gut diversity composition induced by 2'-FL, notably increasing relative abundance Bacteroides Lactobacillus genera. Additionally, significantly elevated levels 5-hydroxytryptamine (5-HT) 5-hydroxytryptophan (5-HTP) hippocampal tissue. However, antibiotic intervention abolished advantage conferred highlighting critical role mediating effects. Similarly, short-term 7 days rapid changes preceding improvements, further suggesting a causal relationship between characteristics cognition. Further, vitro experiments mouse feces suggested that may influence tryptophan hydroxylase inhibit activity decarboxylase, potentially leading increased accumulation 5-HTP. indirectly enterochromaffin cells promoting short-chain fatty acid production, which could support 5-HTP synthesis. Elevated produced system enters bloodstream, crosses blood-brain barrier, brain 5-HT levels. offers preliminary evidence cognitive-promoting be closely associated 5-HT. The findings suggest contribute modulating enhancing brain. Video Abstract.

Язык: Английский

Процитировано

0
Sex-and stage-specific effect of prenatal exposure to organophosphate esters with children's physical growth patterns and adiposity rebound timing: Modification by breastfeeding DOI

Xing Wang,

Juan Tong, Li Han

и другие.

Journal of Hazardous Materials, Год журнала: 2025, Номер 493, С. 138309 - 138309

Опубликована: Апрель 17, 2025

Язык: Английский

Процитировано

0
Gut microbiota modulation: a key determinant of atopic dermatitis susceptibility in children DOI Creative Commons

Huimiao Tang,

Wenxin Li, Yidan Xu

и другие.

Frontiers in Microbiology, Год журнала: 2025, Номер 16

Опубликована: Апрель 28, 2025

Atopic dermatitis is a chronic inflammatory skin condition with higher incidence rate among children. In recent years, the role of gut microbiota in pathogenesis atopic has garnered increasing attention. This review systematically delineates research advancements structural characteristics children and its influencing factors. Studies have revealed significant differences structure between healthy controls, characterized by reduction microbial diversity, decrease beneficial bacteria, an increase harmful bacteria. Dietary patterns, environmental factors, birth antibiotic use, gestational diabetes mellitus are factors could impact hence susceptibility to dermatitis. Moreover, this explores interplay immune system dermatitis, potential inform more effective probiotic treatment strategies for

Язык: Английский

Процитировано

0
The importance of gut microbiome in the perinatal period DOI Creative Commons

Giulia Catassi,

Sandra G. García,

Annamaria Sara Occhionero

и другие.

European Journal of Pediatrics, Год журнала: 2024, Номер unknown

Опубликована: Окт. 3, 2024

Язык: Английский

Процитировано

3
From heart to gut: Exploring the gut microbiome in congenital heart disease DOI Creative Commons
Yuze Liu, Yuan Huang, Qiyu He

и другие.

iMeta, Год журнала: 2023, Номер 2(4)

Опубликована: Окт. 30, 2023

Abstract Congenital heart disease (CHD) is a prevalent birth defect and significant contributor to childhood mortality. The major characteristics of CHD include cardiovascular malformations hemodynamical disorders. However, the impact extends beyond circulatory system. Evidence has identified dysbiosis gut microbiome in patients with CHD. Chronic hypoxia inflammation associated affect microbiome, leading alterations its number, abundance, composition. aside from providing essential nutrients, engages direct interactions host immune system indirect via metabolites. abnormal or products can translocate into bloodstream through an impaired barrier, inflammatory state. Metabolites such as short‐chain fatty acids trimethylamine N ‐oxide, also play important roles development, treatment, prognosis This review discusses role immunity, neurodevelopment, perioperative period By fostering better understanding cross‐talk between this aims contribute improve clinical management outcomes for patients.

Язык: Английский

Процитировано

9