Biomolecules,
Год журнала:
2023,
Номер
14(1), С. 57 - 57
Опубликована: Дек. 31, 2023
The
combustion
of
fossil
fuels
contributes
to
air
pollution
(AP),
which
was
linked
about
8.79
million
global
deaths
in
2018,
mainly
due
respiratory
and
cardiovascular-related
effects.
Among
these,
particulate
(PM2.5)
stands
out
as
a
major
risk
factor
for
heart
health,
especially
during
vulnerable
phases.
Our
prior
study
showed
that
premature
exposure
1,2-naphthoquinone
(1,2-NQ),
chemical
found
diesel
exhaust
particles
(DEP),
exacerbated
asthma
adulthood.
Moreover,
increased
concentration
1,2-NQ
contributed
airway
inflammation
triggered
by
PM2.5,
employing
neurogenic
pathways
related
the
up-regulation
transient
receptor
potential
vanilloid
1
(TRPV1).
However,
impact
early-life
(1,2-NQ)
on
atrial
fibrillation
(AF)
has
not
yet
been
investigated.
This
aims
investigate
how
inhaling
early
life
affects
autonomic
adrenergic
system
role
played
TRPV1
these
disturbances.
C57Bl/6
neonate
male
mice
were
exposed
(100
nM)
or
its
vehicle
at
6,
8,
10
days
life.
Early
impairs
responses
right
atria
without
markedly
affecting
cholinergic
responses.
ECG
analysis
revealed
altered
rhythmicity
young
mice,
suggesting
sympathetic
nervous
activity.
Furthermore,
affected
β1-adrenergic
agonist-mediated
positive
chronotropism,
prevented
metoprolol,
β1
blocker.
Capsazepine,
blocker
but
TRPC5
blocker,
reversed
1,2-NQ-induced
cardiac
changes.
In
conclusion,
AP
results
an
elevated
developing
dysfunction,
potentially
leading
arrhythmia
age.
ABSTRACT
Invasive
mold-associated
cutaneous
disease
is
a
rare
but
potentially
catastrophic
consequence
of
trauma.
However,
invertebrate
bites
are
not
well
recognized
as
mechanism
for
the
inoculation
fungi
into
subcutaneous
tissue
that
can
also
result
in
severe
infections.
Invertebrates
often
carry
with
human
pathogenic
potential
part
their
microbiome,
and
break
skin,
providing
conduit
them
to
penetrate
tissues
where
establishment
infection
produce
serious
skin
soft
fungal
diseases.
In
this
essay,
we
review
existing
data
bite-associated
invasive
infections
(IBA-cIFIs)
consider
consequences
global
warming
on
epidemiology.
Climate
changes
will
be
associated
range
invertebrates
adaptation
microbes
warmer
temperatures.
Fungal
higher
temperatures
defeat
mammalian
protective
barrier
both
more
different
IBA-cIFIs.
Health Science Reports,
Год журнала:
2025,
Номер
8(4)
Опубликована: Апрель 1, 2025
ABSTRACT
Background
and
Aims
Human
activities
have
greatly
influenced
global
temperatures,
leading
to
climate
change
warming.
This
narrative
review
aims
explore
the
relationship
between
immune
system,
focusing
on
how
environmental
stressors
can
affect
regulation,
both
hyperactivity
suppression.
Methods
A
comprehensive
search
was
conducted
in
PubMed
Google
Scholar
for
peer‐reviewed
studies
published
up
June
2024.
The
terms
included
“climate
change,”
“human
health,”
“infection,”
“immunity,”
“disease.”
Inclusion
criteria
were
based
relevance,
originality,
accessibility.
Results
Exposure
elevated
temperatures
significantly
impair
system
cells,
an
overproduction
of
signaling
molecules
that
promote
inflammation.
Temperature
fluctuations
been
shown
influence
various
aspects
adaptive
response,
including
cell
mobilization,
antigen
processing
presentation,
lymphocyte
trafficking
activation,
functionality
B
T
cells.
Notably,
some
research
suggests
heat
stress
negatively
impacts
differentiation,
replication,
proportion,
resulting
decreased
immunoglobulin
cytokine
production,
contributing
immunosuppression.
Additionally,
change‐related
exposures
compromise
epithelial
barriers
skin,
lungs,
gut,
microbial
dysbiosis,
dysregulation.
Furthermore,
factors
such
as
temperature
variations,
humidity,
air
pollutant
levels
may
exacerbate
prevalence
infectious
diseases,
measles
HIV,
with
varying
acute,
chronic,
latent
infections,
further
variability.
Conclusion
Climate
change,
particularly
increased
function,
heightened
inflammatory
responses,
Future
should
focus
developing
sustainable
management
strategies
enhance
health
resilience
face
ongoing
climatic
changes.
Rhinitis
arises
from
either
allergic
or
non-allergic
inflammation
of
the
nasal
mucosa,
characterized
by
infiltration
inflammatory
cells
into
tissue
and
secretions,
along
with
structural
alterations
in
mucosa.
The
pathways
through
which
air
pollution
affects
rhinitis
may
diverge
those
affecting
asthma.
This
article
aims
to
review
effects
diverse
pollutants
on
nose,
correlation
climate
change
pollution,
how
they
aggravate
symptoms
patients
rhinitis.
Abstract
The
skin
serves
as
the
first
protective
barrier
for
nonspecific
immunity
and
encompasses
a
vast
network
of
skin‐associated
immune
cells.
Atopic
dermatitis
(AD)
is
prevalent
inflammatory
disease
that
affects
individuals
all
ages
races,
with
complex
pathogenesis
intricately
linked
to
genetic,
environmental
factors,
dysfunction
well
dysfunction.
Individuals
diagnosed
AD
frequently
exhibit
genetic
predispositions,
characterized
by
mutations
impact
structural
integrity
barrier.
This
leads
release
alarmins,
activating
type
2
pathway
recruiting
various
cells
skin,
where
they
coordinate
cutaneous
responses.
In
this
review,
we
summarize
experimental
models
provide
an
overview
its
therapeutic
interventions.
We
focus
on
elucidating
intricate
interplay
between
system
regulatory
mechanisms,
commonly
used
treatments
AD,
aiming
systematically
understand
cellular
molecular
crosstalk
in
AD‐affected
skin.
Our
overarching
objective
novel
insights
inform
potential
clinical
interventions
reduce
incidence
AD.
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Май 22, 2024
ABSTRACT
Objectives
A
nationwide
study
of
the
impact
high
temperature
on
respiratory
disease
hospitalizations
among
older
adults
(65+)
living
in
large
urban
centers.
Methods
Daily
rates
short-stay,
inpatient
were
examined
with
respect
to
variations
ZIP-code-level
daily
mean
120
largest
US
cities
between
2000-2017.
For
each
city,
we
estimated
cumulative
associations
(lag-days
0-6)
warm-season
temperatures
(June-September)
and
cause-specific
using
time-stratified
conditional
quasi-Poisson
regression
distributed
lag
non-linear
models.
We
meta-regression
updated
city-specific
via
best
linear
unbiased
prediction.
With
stratified
models,
explored
effect
modification
by
age,
sex,
race
(Black/white).
Results
reported
as
percent
change
at
(95th
percentile)
compared
median
for
outcome,
demographic-group,
metropolitan
area.
Excess
hospitalization
days
above
temperatures.
At
temperatures,
observed
increases
all-cause
[1.2
(0.4,
2.0)],
primarily
driven
an
increase
tract
infections
[1.8
(0.6,
3.0)],
chronic
diseases/respiratory
failure
(0.0,
2.4)].
East
North
Central,
New
England,
Mid-Atlantic,
Pacific
accounted
98.5%
excess
burden.
By
demographic
group,
disproportionate
burdens
heat-related
oldest
beneficiaries
(85+
years),
Black
South
Atlantic
cities.
Conclusion
This
found
robust
impacts
inflammatory
fibrotic
diseases
adults.
The
geographic
variation
suggests
that
contextual
factors
account
burdens.
