Antioxidant and Anti-Inflammatory Effects of Carotenoids in Mood Disorders: An Overview

Antioxidants, Год журнала: 2023, Номер 12(3), С. 676 - 676

Опубликована: Март 9, 2023

Depression has a multifactorial etiology comprising family history and unemployment. This review aims to summarize the evidence available for antioxidant anti-inflammatory effects of carotenoids in mood disorders. article’s methodologies were based on search PubMed database all linked published papers. Epidemiological studies indicate that diet rich vegetables, fruits, nuts, fish, olive oil may prevent development depression. Antioxidant supplementation been found combat various stress-induced psychiatric disorders, including depression anxiety. A growing body indicates have both anti-inflammatory. Studies also suggest poor dietary intake, particularly low intakes fruit vegetables high fast food other convenience foods, increase risk developing Thus, interventions potential help mitigate mental health decline general population those with Considering effects, it is expected they might exert promising antidepressant effect. Nevertheless, further (including interventional mechanistic studies) assessing effect preventing alleviating symptoms are needed.

Язык: Английский

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Balancing the Mind: Toward a Complete Picture of the Interplay between Gut Microbiota, Inflammation and Major Depressive Disorder

Brain Research Bulletin, Год журнала: 2024, Номер 216, С. 111056 - 111056

Опубликована: Авг. 24, 2024

The intricate interplay existing between gut microbiota and homeostasis extends to the realm of brain, where emerging research underscores significant impact on mood regulation overall neurological well-being vice-versa, with inflammation playing a pivotal role in mediating these complex interactions. This comprehensive review explores inflammation, alterations microbiota, their major depressive disorder (MDD). It provides cohesive framework for puzzle pieces this triad, emphasizing recent advancements understanding inflammatory states' contribution features. Two directions communication brain depression are discussed, serving as potential modulator. Therapeutic implications were discussed well, drawing insights from interventional studies effects probiotics bacterial composition symptoms. Ultimately, will attempt provide complete valuable future therapeutic interventions MDD.

Язык: Английский

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Association of the newly proposed dietary index for gut microbiota and depression: the mediation effect of phenotypic age and body mass index

European Archives of Psychiatry and Clinical Neuroscience, Год журнала: 2024, Номер unknown

Опубликована: Окт. 8, 2024

Язык: Английский

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Causal effects of gut microbiota on the risk of periodontitis: a two-sample Mendelian randomization study

Frontiers in Cellular and Infection Microbiology, Год журнала: 2023, Номер 13

Опубликована: Май 25, 2023

Introduction The oral cavity and the gut tract are interconnected, both contain abundant natural microbiota. Gut microbiota may interact with flora participate in development of periodontitis. However, specific role certain taxa for periodontitis has not been investigated. Mendelian Randomization is an ideal method to explore causal relationships avoiding reverse causality potential confounding factors. Thus, we conducted a two-sample study comprehensively reveal genetic effect on Methods SNPs strongly associated 196 (18,340 individuals) were selected as instrument variables, (17,353 cases 28,210 controls) was used outcome. analyzed via random inverse variance-weighted, weighted median, MR-Egger. sensitivity analyses using Cochran’s Q tests, funnel plots, leave-one-out analyses, MR-Egger intercept tests. Results Nine ( Prevotella 7, Lachnospiraceae UCG-008, Enterobacteriales , Pasteurellales Enterobacteriaceae Pasteurellaceae Bacteroidales S24.7 group, Alistipes Eisenbergiella ) predicted play enhancing risk p < 0.05). Besides, two Butyricicoccus Ruminiclostridium 6) have potentially inhibitive effects No significant estimation heterogeneity or pleiotropy detected. Conclusion Our demonstrates provides guidance clinical intervention

Язык: Английский

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The relationship between major depression and migraine: A bidirectional two-sample Mendelian randomization study

Frontiers in Neurology, Год журнала: 2023, Номер 14

Опубликована: Апрель 14, 2023

Previous epidemiological and other studies have shown an association between major depressive disorder (MDD) migraine. However, the causal relationship them remains unclear. Therefore, this study aimed to investigate MDD migraine using a bidirectional, two-sample Mendelian randomization (MR) approach.

Язык: Английский

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The bidirectional interaction between antidepressants and the gut microbiota: are there implications for treatment response?

International Clinical Psychopharmacology, Год журнала: 2024, Номер 40(1), С. 3 - 26

Опубликована: Фев. 6, 2024

This review synthesizes the evidence on associations between antidepressant use and gut microbiota composition function, exploring microbiota's possible role in modulating treatment outcomes. Antidepressants exert an influence measures of microbial diversity. The most consistently reported differences were β-diversity those exposed to antidepressants not exposed, with longitudinal studies supporting a potential causal association. Compositional alterations users include increase Bacteroidetes phylum, Christensenellaceae family, Bacteroides Clostridium genera, while decrease was found Firmicutes Ruminococcaceae Ruminococcus genus. In addition, attenuate depressed healthy individuals, modulate serotonin transport, metabolic functions. These lyxose degradation, peptidoglycan maturation, membrane methylerythritol phosphate pathways, alongside gamma-aminobutyric acid metabolism. Importantly, baseline increased α-diversity abundance Roseburia Faecalibacterium are associated response, emerging as promising biomarkers. highlights for predictor response emphasizes need further research elucidate mechanisms underlying antidepressant-microbiota interactions. More homogeneous standardized techniques required confirm these initial findings.

Язык: Английский

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Metabolites and Coronary heart disease: A Two Sample Mendelian Randomization

International Journal of Cardiology Cardiovascular Risk and Prevention, Год журнала: 2025, Номер unknown, С. 200365 - 200365

Опубликована: Янв. 1, 2025

Язык: Английский

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A novel framework for assessing causal effect of microbiome on health: long-term antibiotic usage as an instrument

Gut Microbes, Год журнала: 2025, Номер 17(1)

Опубликована: Янв. 23, 2025

Assessing causality is undoubtedly one of the key questions in microbiome studies for upcoming years. Since randomized trials human subjects are often unethical or difficult to pursue, analytical methods derive causal effects from observational data deserve attention. As simple covariate adjustment not likely account all potential confounders, idea instrumental variable (IV) analysis worth exploiting. Here we propose a novel framework antibiotic regression (AB-IVR) estimating relationships between and various diseases. We rely on recent showing that treatment has cumulative long-term effect microbiome, resulting individuals with higher usage have more perturbed microbiome. apply AB-IVR method Estonian Biobank show role numerous diseases including migraine, depression irritable bowel syndrome. plethora sensitivity analyses identified robust ways further methodological developments.

Язык: Английский

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Association between gut microbiota and primary ovarian insufficiency: a bidirectional two-sample Mendelian randomization study

Frontiers in Endocrinology, Год журнала: 2023, Номер 14

Опубликована: Июнь 22, 2023

Background Recent studies have indicated a potential correlation between intestinal bacteria and primary ovarian insufficiency (POI). However, the causal relationship gut microbiota (GM) POI remains unclear. Methods A bidirectional two-sample Mendelian randomization (MR) study was conducted to investigate GM POI. Data on were based MiBioGen consortium's summary statistics from most comprehensive genome-wide association meta-analysis date (n=13,266), data obtained R8 release of FinnGen consortium, containing total 424 cases 181,796 controls. variety analytical methods, including inverse variance weighting, maximum likelihood, MR-Egger, weighted median, constrained likelihood model averaging Bayesian information criterion, utilized explore connection The Cochran's Q used evaluate heterogeneity instrumental variables. MR-Egger MR-pleiotropy residual sum outlier (PRESSO) methods identify horizontal pleiotropy MR Steiger test strength relationships. reverse performed targeted GMs which with in forward evaluation. Results analysis that Eubacterium (hallii group) (odds ratio [OR]=0.49, 95% confidence interval [CI]: 0.26–0.9, P=0.022) (ventriosum (OR=0.51, CI: 0.27–0.97, P=0.04) had protective effects POI, Intestinibacter (OR=1.82, 1.04–3.2, P=0.037) Terrisporobacter (OR=2.47, 1.14–5.36, detrimental no significant influence four GMs. No or observed performance Conclusion This revealed link group), Intestinibacter, Additional clinical trials are needed gain clearer understanding beneficial their mechanisms action.

Язык: Английский

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Causal associations between human gut microbiota and cholelithiasis: a mendelian randomization study

Frontiers in Cellular and Infection Microbiology, Год журнала: 2023, Номер 13

Опубликована: Май 25, 2023

There was some evidence that gut microbiota closely related to cholelithiasis, but the causal relationship between them remained unclear. In this study, we try use Two-sample Mendelian randomization (MR) clarify potential and cholelithiasis.Summary Genome-Wide Association Studies (GWAS) statistical data for obtained from MiBioGen, of cholelithiasis UK Biobank (UKB). MR analyses were performed assess causalities mainly using inverse-variance weighted (IVW) method. Sensitivity used determine robustness results. Reverse examine reverse association.Our research results, based primarily on IVW method, support existence a nine microbial taxa cholelithiasis. We observed positive association Genus Butyrivibrio (p=0.032), Lachnospiraceae_UCG_001 (p=0.015), Ruminococcaceae_NK4A214_group (p=0.003), Ruminococcaceae_UCG_011 (p=0.010) while Order Rhodospirillales (p=0.031), Actinomyces (p=0.010), Phascolarctobacterium (p=0.036), Rikenellaceae_RC9_gutgroup (p=0.023), Ruminococcaceae_UCG_013 (p=0.022) may be associated with reduced risk did not find 9 specific taxa.This is first mendelian study explore which provide new ideas theoretical basis prevention treatment in future.

Язык: Английский

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