Ketamine and Nitrous Oxide DOI
Alvin M. Janski, Vasilis Hristidis, Charles F. Zorumski

и другие.

Elsevier eBooks, Год журнала: 2023, Номер unknown

Опубликована: Дек. 19, 2023

Язык: Английский

Redefining Ketamine Pharmacology for Antidepressant Action: Synergistic NMDA and Opioid Receptor Interactions? DOI
Marjorie R. Levinstein,

Reece C. Budinich,

Jordi Bonaventura

и другие.

American Journal of Psychiatry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

Ketamine is a racemic compound and medication comprised of (S)-ketamine (R)-ketamine enantiomers its metabolites. It has been used for decades as dissociative anesthetic, analgesic, recreational drug. More recently, ketamine, enantiomers, metabolites have or are being investigated the treatment refractory depression, well comorbid disorders such anxiety, obsessive-compulsive, opioid use disorders. Despite complex pharmacology, ketamine referred to an N-methyl-d-aspartate (NMDA) receptor antagonist. In this review, authors argue that ketamine's pharmacology should be redefined include receptors endogenous system. They also highlight potential mechanism action depression attributed bifunctional, synergistic interactions involving NMDA receptors.

Язык: Английский

Процитировано

3

Therapeutic mechanisms of psychedelics and entactogens DOI
Boris D. Heifets, David E. Olson

Neuropsychopharmacology, Год журнала: 2023, Номер 49(1), С. 104 - 118

Опубликована: Июль 24, 2023

Язык: Английский

Процитировано

30

Perspectives in treatment-resistant depression: esketamine and electroconvulsive therapy DOI
P. Baldinger, Marie Spies, Ina Bozic

и другие.

Wiener klinische Wochenschrift, Год журнала: 2024, Номер unknown

Опубликована: Апрель 17, 2024

Язык: Английский

Процитировано

5

Intravenous Ketamine Treatment for Depression: One-year Retrospective Study from a Tertiary Care Psychiatry Center from India DOI Creative Commons

Ekta Yadav,

Bheemsain Tekkalaki,

Kavita P. Gadadavar

и другие.

Indian Journal of Psychological Medicine, Год журнала: 2025, Номер unknown

Опубликована: Апрель 29, 2025

Major depressive disorder (MDD) is a debilitating mental health condition characterized by significant morbidity and mortality. The emergence of ketamine infusion therapy has provided promising, rapidly acting treatment option. We aimed to assess the effectiveness as an adjunct in patients with depression study patient's profile undergoing real-world clinical setting. This was retrospective chart review. A total 28 who received at tertiary care hospital were included this analysis. Hamilton Depression Rating Scale (HAMD) utilized symptomatology. statistically reduction HAMD scores observed post-treatment (P < .0001). Notably, 53.6% achieved therapeutic response (≥50% decrease score), while 39.3% attained remission (HAMD score 7) after average 4.6 infusions. Furthermore, substantial suicidal ideation 71.4% patients. finding indicates that safe effective for depression.

Язык: Английский

Процитировано

0

Attitudes and Perceptions of Portuguese Psychiatrists and Psychologists on the Clinical Use of Ketamine DOI Creative Commons
Pedro Mota, Jorge Encantado, Lina Carvalho

и другие.

Acta Médica Portuguesa, Год журнала: 2025, Номер 38(5), С. 297 - 306

Опубликована: Май 2, 2025

Introduction: Ketamine has garnered attention for its rapid efficacy in alleviating depressive symptoms treatment-resistant depression, offering a novel mechanism as non-monoaminergic agent. Despite potential, limited research explored mental health professionals’ perspectives on use. This study assesses the attitudes, knowledge, and concerns of Portuguese psychiatrists psychologists regarding clinical application ketamine depression.Methods: A cross-sectional survey was conducted from June 2022 to January 2024 among psychologists. The anonymous online questionnaire assessed perceptions ketamine’s therapeutic utility, risks, knowledge sources. Statistical analyses examined subgroup differences by age, sex, profession, prior psychedelic use.Results: Among 156 participants (mean age = 37.2; 68.6% female), 53.8% were psychologists, 46.2% or trainees Psychiatry. Only 35.9% reported substantial while 59% open integrating it clinically. majority expressed interest training, though 73% raised about inadequate professional training. Significant emerged, with reporting higher levels openness compared younger professionals showed greater training usage.Conclusion: There favorable attitude toward use yet educational gaps remain. Customized addressing background is essential safe effective integration depression. Further studies should focus longitudinal outcomes treatment under standardized protocols ensure safety practice.

Язык: Английский

Процитировано

0

Ketamine for depressive symptoms: A retrospective chart review of a private ketamine clinic DOI Creative Commons
Vidette Juby,

Saaeda Paruk,

Mitsuaki Tomita

и другие.

South African Journal of Psychiatry, Год журнала: 2024, Номер 30

Опубликована: Фев. 8, 2024

There is currently no published evidence demonstrating the effectiveness and safety of subanaesthetic doses ketamine, when administered intravenously as an adjunct treatment for depressive symptoms, in a real world setting South Africa.

Язык: Английский

Процитировано

2

Pluripotential GluN1 (NMDA NR1): Functional Significance in Cellular Nuclei in Pain/Nociception DOI Open Access

Terry A. McNearney,

Karin N. Westlund

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(17), С. 13196 - 13196

Опубликована: Авг. 25, 2023

The N-methyl-D-aspartate (NMDA) glutamate receptors function as plasma membrane ionic channels and take part in very tightly controlled cellular processes activating neurogenic inflammatory pathways. In particular, the NR1 subunit (new terminology: GluN1) is required for many neuronal non-neuronal cell functions, including plasticity, survival, differentiation. Physiologic levels of agonists NMDA receptor activation are normal functions such development, learning, memory. When present excess, binding to produces neuronal/CNS/PNS long-term potentiation, conditions acute pain, ongoing severe intractable potential excitotoxicity pathology. GluNR1 (116 kD) necessary anchor component directing ion channel heterodimer formation, trafficking, nuclear localization that directs functionally specific functions. Emerging studies report relevance GluN1 composition specifically has major physiologic tissue and/or subnuclear functioning assignments. shift from a surface assigns promoter immediate early gene behavior with access potentially nucleolar narrative review addresses translocation GluN1, focusing particularly on examples role nociceptive processes.

Язык: Английский

Процитировано

4

Prolonged ketamine therapy differentially rescues psychobehavioural deficits via modulation of nitro-oxidative stress and oxytocin receptors in the gut-brain-axis of chronically-stressed mice DOI
Edem Ekpenyong Edem,

Oluwatomisn Adeyosola Oguntala,

Daniel Akinwale Ikuelogbon

и другие.

Psychoneuroendocrinology, Год журнала: 2023, Номер 158, С. 106370 - 106370

Опубликована: Авг. 23, 2023

Язык: Английский

Процитировано

2

Embracing pragmatism for ketamine insurance coverage: Leveraging real-world evidence DOI
L. Alison McInnes, Tobias F. Marton,

Jimmy Qian

и другие.

Journal of Affective Disorders, Год журнала: 2024, Номер 352, С. 199 - 200

Опубликована: Фев. 11, 2024

Язык: Английский

Процитировано

0

Improvement of Mental Health Symptoms in Response to Ketamine Therapy in Medicaid-Eligible Patients DOI Open Access

Bonnett CJ,

Jaclyn Bonder,

Rakesh K. Jain

и другие.

Journal of Psychiatry and Mental Health, Год журнала: 2024, Номер 8(1)

Опубликована: Янв. 1, 2024

Since 2020 there has been an expansion in the number of studies highlighting positive effect that Ketamine for Non-Anesthetic Indications (KNAI) can have on patients suffering with mental health disorders. Medicaid programs cover a large community face significant disparities and suffer more frequently from conditions. Many these conditions are exacerbated due to socioeconomic stressors, lack access care, poor support systems. Our case study focuses 289 Medicaid-eligible ketamine treatment had their symptoms. These participants established diagnosis Generalized Anxiety Disorder (GAD), Major Depressive (MDD) and/or Post Traumatic Stress (PTSD) prior beginning treatment. The GAD-7, PHQ-9, PCL-5 surveys were utilized assessment symptomatology this cohort patients. instruments all deployed at end six-session Induction Series treatments. comparison scores screening pre-and post-treatment demonstrated clinically reduction three cohorts listed above.

Язык: Английский

Процитировано

0