The Effects and Mechanisms of n-3 and n-6 Polyunsaturated Fatty Acids in the Central Nervous System
Cellular and Molecular Neurobiology,
Год журнала:
2025,
Номер
45(1)
Опубликована: Март 17, 2025
The
brain
is
rich
in
fatty
acids
(FAs),
with
polyunsaturated
(PUFAs),
such
as
docosahexaenoic
acid
(C22:6n-3,
DHA)
and
arachidonic
(C20:4n-6,
ARA),
the
former
predominantly
stored
form
of
phosphatidylcholine,
phosphatidyl
ethanolamine
(PE,
diacyl
plasma
phospholipid
proform),
phosphatidylserine
(PS),
while
latter
mainly
found
phosphoglycerides
(EPG)
contributes
to
constitute
most
phosphoglycerides.
When
required
by
body,
PUFAs
are
liberated
from
membrane
phospholipids
(either
directly
or
via
their
metabolites,
which
generated
a
series
enzymatic
reactions)
participate
various
cerebral
physiological
processes.
derivatives
play
crucial
roles
modulating
numerous
bodily
functions,
including
neuronal
signal
transmission,
neurogenesis,
neuroinflammation,
glucose
uptake
brain,
thereby
sustaining
fundamental
function.
Although
have
been
implicated
spectrum
neurological
disorders,
acute
injury
(TBI),
multiple
sclerosis
(MS),
neurodegenerative
diseases,
role
conditions
depression,
Alzheimer's
disease
(AD),
Parkinson's
(PD)
particularly
noteworthy.
These
disorders
closely
linked
critical
cognition,
memory,
inflammatory
Given
substantial
body
research
elucidating
involvement
pathogenesis
progression
these
this
review
will
specifically
concentrate
on
impact
within
contexts.
Язык: Английский
The relationships of resting-state brain entropy (BEN), ovarian hormones and behavioral inhibition and activation systems (BIS/BAS)
NeuroImage,
Год журнала:
2025,
Номер
312, С. 121226 - 121226
Опубликована: Апрель 21, 2025
Язык: Английский
Integrative flavoromics-GC-MS/IMS approach to study the formation mechanism of fishy flavor in skipjack tuna oil induced by oxidation and heat
Food Chemistry X,
Год журнала:
2025,
Номер
unknown, С. 102577 - 102577
Опубликована: Май 1, 2025
Язык: Английский
Recommendations for nutritional supplements for dry eye disease: current advances
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Май 30, 2024
Dry
eye
disease
(DED)
represents
a
prevalent
ocular
surface
disease.
The
development
of
effective
nutritional
management
strategies
for
DED
is
crucial
due
to
its
association
with
various
factors
such
as
inflammation,
oxidative
stress,
deficiencies
in
polyunsaturated
fatty
acids
(PUFAs),
imbalanced
PUFA
ratios,
and
vitamin
insufficiencies.
Extensive
research
has
explored
the
impact
oral
supplements,
varying
composition
dosage,
on
symptoms
DED.
main
components
these
supplements
include
fish
oils
(Omega-3
acids),
vitamins,
trace
elements,
phytochemical
extracts.
Beyond
well-known
nutrients,
it
necessary
explore
whether
novel
nutrients
might
contribute
more
management.
This
review
provides
comprehensive
update
therapeutic
potential
presents
new
perspectives
combination
treatment.
Язык: Английский
Comparison of Omega-3 polyunsaturated fatty acids bioavailability in fish oil and krill oil: Network Meta-analyses
Food Chemistry X,
Год журнала:
2024,
Номер
24, С. 101880 - 101880
Опубликована: Окт. 5, 2024
Background
and
Aims:
Fish
oil
krill
are
primary
sources
of
Omega-3
polyunsaturated
fatty
acids
(PUFAs),
differing
in
their
molecular
forms
bioavailability.
Understanding
these
differences
can
optimize
therapeutic
use.
This
study
aims
to
compare
the
bioavailability
PUFAs
fish
using
a
network
meta-analysis
approach.
By
evaluating
various
dosages,
seeks
identify
most
effective
dosing
regimens
maximize
health
benefits.
Methods:
The
adhered
explanation
PRISMA
2015
(registered
PROSPERO
ID:
CRD42024532536).
risk
bias
was
evaluated
PEDro
scale.
incorporated
data
from
studies
published
between
2003
2023,
sourced
five
databases:
ClinicalTrials.gov,
PubMed,
Cochrane
CENTRAL,
International
Clinical
Trials
Registry
Platform-World
Health
Organization,
Embase.
Statistical
analysis
conducted
advanced
models
R
software
ensure
rigorous
evaluation
Results:
Out
26
high-quality
studies,
findings
reveal
superior
compared
oil.
Specifically,
above
3000
mg,
re-esterified
triacylglycerol
or
ethyl
ester
formulations
(100-2900
mg),
(100-1900
mg)
significantly
enhanced
index.
At
lower
dosages
(under
2000
shows
absorption
Using
at
doses
2900
mg
may
be
for
reducing
Tmax.
However,
this
finding
should
interpreted
with
caution
due
high
heterogeneity
limited
statistical
significance.
highest
AUC
values
were
observed
phospholipid/free
acid
formulation.
Emulsion
more
increasing
Cmax
than
other
formulations.
These
results
supported
by
robust
evidence
(Egger's
test,
p
>
0.05),
highlighting
effectiveness
specific
optimizing
absorption.
Conclusion:
research
highlights
importance
understanding
suggest
that
low-dose
emulsions
potentially
safer
alternatives
high-dose
oil,
minimizing
adverse
effects.
Язык: Английский
Omega-3 polyunsaturated fatty acids in depression: insights from recent clinical trials
Current Opinion in Clinical Nutrition & Metabolic Care,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 24, 2024
This
review
examines
evidence
from
recent
clinical
trials
on
the
therapeutic
potential
of
omega-3
polyunsaturated
fatty
acids
(PUFAs)
in
major
depressive
disorder
(MDD).
We
focus
effects
MDD
with
comorbidities,
younger
populations,
and
high-inflammation
presentations.
PubMed,
Cochrane,
Embase
databases
were
systematically
searched
for
studies
published
between
May
2022
2024.
The
search
was
conducted
randomized
controlled
using
PUFAs
participants
a
diagnosis
depression.Higher
doses
eicosapentaenoic
acid
(EPA)
(>1
g/day)
improved
measures
depression,
particularly
elevated
inflammation
markers,
comorbid
cardiovascular
diseases,
late-life
onset,
children
adolescent
populations.
Improvements
symptoms
associated
increases
PUFA-derived
anti-inflammatory
proresolving
lipid
mediators.
As
adjuvant
treatments,
have
benefits
mood,
cognitive
metabolic
functions,
kynurenine
serotonin
pathways,
alterations
corticolimbic
functional
connectivity.
While
suggests
promise,
high-dose
EPA
inflammatory
subtypes,
more
research
is
needed
to
establish
optimal
dosing
regimens,
treatment
duration,
patient
subgroups
most
likely
benefit.
Future
should
sex
differences,
long-term
effects,
synergies
other
treatments.
Язык: Английский
Comparison of Omega-3 Polyunsaturated Fatty Acids Bioavailability in Fish Oil and Krill Oil: Network Meta-Analyses
Опубликована: Янв. 1, 2024
Язык: Английский
Dietary omega-3 intake and cognitive function in older adults
The International Journal of Psychiatry in Medicine,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 15, 2024
Objective
Dietary
habits
have
long
been
known
to
be
a
critical
factor
influencing
cognitive
health,
especially
among
older
adults.
Despite
extensive
research
on
various
dietary
components,
the
impact
of
omega-3
polyunsaturated
fatty
acids
(PUFAs)
function
has
not
yet
thoroughly
investigated.
This
seeks
determine
whether
more
intake
PUFAs
correlates
with
improved
in
Methods
Data
were
analyzed
from
National
Health
and
Nutrition
Examination
Survey
(NHANES),
which
included
2430
elderly
participants
aged
60
above.
The
association
between
consumption
outcomes
was
evaluated
using
linear
regression
models.
Smoothing
curves
threshold
effect
analysis
employed
examine
nonlinear
associations.
Subgroup
studies
conducted
demonstrate
strength
reliability
correlation
factors
affecting
them.
Results
fully
adjusted
model
demonstrated
significant
positive
correlations
scores
all
3
assessments
performed.
Specifically,
final
model,
beta
coefficients
for
CERAD
Word
Learning
test,
Animal
Fluency
Test,
Digit
Symbol
Substitution
Test
0.53
(95%
CI:
0.33-0.72;
P
<
0.0001),
0.29
0.12-0.47;
=
0.001),
0.61
0.19-1.03;
0.0045),
respectively.
Conclusion
Increased
positively
independently
associated
adults,
suggesting
that
may
help
prevent
decline
aging.
Prospective
are
needed
direct
this
association.
Язык: Английский
Comparative Bioavailability of Omega-3 Polyunsaturated Fatty Acids in Fish Oil and Krill Oil: A Network Meta-Analysis
SSRN Electronic Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Background
and
aims:
Despite
the
known
health
benefits
of
Omega-3
polyunsaturated
fatty
acids
(PUFAs),
comparative
bioavailability
these
nutrients
from
fish
oil
(FO)
krill
(KO)
remains
inadequately
explored.
This
study
addresses
gap
by
evaluating
various
forms
doses
PUFAs
in
FO
KO,
utilizing
a
network
meta-analysis
approach.Methods:
The
adhered
to
PRISMA
2015
guidelines.
risk
bias
was
evaluated
using
PEDro
scale.
incorporated
data
studies
published
between
1993
2023,
analyzed
different
assessing
daily
categorized
into
three
levels
based
on
their
DHA+EPA
content.
Statistical
analysis
conducted
advanced
models
R
software
ensure
rigorous
evaluation
bioavailability.
PROSPERO
ID:
CRD42024532536.Results:
Out
40
high-quality
studies,
findings
this
reveal
superior
KO
compared
at
equivalent
doses.
Specifically,
above
3000
mg,
re-esterified
triacylglycerol
(100
-
4000
mg)
ethyl
ester
(2000
significantly
enhanced
levels,
DHA
EPA,
with
highest
AUC
values
observed
phospholipid/free
acid
form
1900
emulsion
mg).
These
results
were
supported
robust
statistical
evidence
(Egger's
test,
p
>
0.05),
highlighting
effectiveness
specific
formulations
optimizing
absorption.
Conclusion:
is
first
systematically
compare
across
wide
range
Notably,
higher
FO,
specifically
those
exceeding
such
as
ranging
100
2900
have
shown
effectively
enhance
O3i,
DHA,
EPA;
although
focused
low
mg.
Future
research
should
further
investigate
dose-response
relationship
oils
better
inform
clinical
dietary
Язык: Английский