Dietary omega-3 intake and cognitive function in older adults DOI
Bingdian Wang,

D. Li,

Cuicui Peng

et al.

The International Journal of Psychiatry in Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 15, 2024

Objective Dietary habits have long been known to be a critical factor influencing cognitive health, especially among older adults. Despite extensive research on various dietary components, the impact of omega-3 polyunsaturated fatty acids (PUFAs) function has not yet thoroughly investigated. This seeks determine whether more intake PUFAs correlates with improved in Methods Data were analyzed from National Health and Nutrition Examination Survey (NHANES), which included 2430 elderly participants aged 60 above. The association between consumption outcomes was evaluated using linear regression models. Smoothing curves threshold effect analysis employed examine nonlinear associations. Subgroup studies conducted demonstrate strength reliability correlation factors affecting them. Results fully adjusted model demonstrated significant positive correlations scores all 3 assessments performed. Specifically, final model, beta coefficients for CERAD Word Learning test, Animal Fluency Test, Digit Symbol Substitution Test 0.53 (95% CI: 0.33-0.72; P < 0.0001), 0.29 0.12-0.47; = 0.001), 0.61 0.19-1.03; 0.0045), respectively. Conclusion Increased positively independently associated adults, suggesting that may help prevent decline aging. Prospective are needed direct this association.

Language: Английский

The Effects and Mechanisms of n-3 and n-6 Polyunsaturated Fatty Acids in the Central Nervous System DOI Creative Commons
Jiajia Tian, Yating Zhang, Xudong Zhao

et al.

Cellular and Molecular Neurobiology, Journal Year: 2025, Volume and Issue: 45(1)

Published: March 17, 2025

The brain is rich in fatty acids (FAs), with polyunsaturated (PUFAs), such as docosahexaenoic acid (C22:6n-3, DHA) and arachidonic (C20:4n-6, ARA), the former predominantly stored form of phosphatidylcholine, phosphatidyl ethanolamine (PE, diacyl plasma phospholipid proform), phosphatidylserine (PS), while latter mainly found phosphoglycerides (EPG) contributes to constitute most phosphoglycerides. When required by body, PUFAs are liberated from membrane phospholipids (either directly or via their metabolites, which generated a series enzymatic reactions) participate various cerebral physiological processes. derivatives play crucial roles modulating numerous bodily functions, including neuronal signal transmission, neurogenesis, neuroinflammation, glucose uptake brain, thereby sustaining fundamental function. Although have been implicated spectrum neurological disorders, acute injury (TBI), multiple sclerosis (MS), neurodegenerative diseases, role conditions depression, Alzheimer's disease (AD), Parkinson's (PD) particularly noteworthy. These disorders closely linked critical cognition, memory, inflammatory Given substantial body research elucidating involvement pathogenesis progression these this review will specifically concentrate on impact within contexts.

Language: Английский

Citations

0
The relationships of resting-state brain entropy (BEN), ovarian hormones and behavioral inhibition and activation systems (BIS/BAS) DOI
Donghui Song, Ze Wang

NeuroImage, Journal Year: 2025, Volume and Issue: 312, P. 121226 - 121226

Published: April 21, 2025

Language: Английский

Citations

0
Recommendations for nutritional supplements for dry eye disease: current advances DOI Creative Commons

Ying Cong,

Yibing Zhang,

Yutong Han

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 30, 2024

Dry eye disease (DED) represents a prevalent ocular surface disease. The development of effective nutritional management strategies for DED is crucial due to its association with various factors such as inflammation, oxidative stress, deficiencies in polyunsaturated fatty acids (PUFAs), imbalanced PUFA ratios, and vitamin insufficiencies. Extensive research has explored the impact oral supplements, varying composition dosage, on symptoms DED. main components these supplements include fish oils (Omega-3 acids), vitamins, trace elements, phytochemical extracts. Beyond well-known nutrients, it necessary explore whether novel nutrients might contribute more management. This review provides comprehensive update therapeutic potential presents new perspectives combination treatment.

Language: Английский

Citations

2
Comparison of Omega-3 polyunsaturated fatty acids bioavailability in fish oil and krill oil: Network Meta-analyses DOI Creative Commons
Thi-Phuong-Thao Pham, Thi-Van Hoang,

Phuc-Thao-Nguyen Cao

et al.

Food Chemistry X, Journal Year: 2024, Volume and Issue: 24, P. 101880 - 101880

Published: Oct. 5, 2024

Background and Aims: Fish oil krill are primary sources of Omega-3 polyunsaturated fatty acids (PUFAs), differing in their molecular forms bioavailability. Understanding these differences can optimize therapeutic use. This study aims to compare the bioavailability PUFAs fish using a network meta-analysis approach. By evaluating various dosages, seeks identify most effective dosing regimens maximize health benefits. Methods: The adhered explanation PRISMA 2015 (registered PROSPERO ID: CRD42024532536). risk bias was evaluated PEDro scale. incorporated data from studies published between 2003 2023, sourced five databases: ClinicalTrials.gov, PubMed, Cochrane CENTRAL, International Clinical Trials Registry Platform-World Health Organization, Embase. Statistical analysis conducted advanced models R software ensure rigorous evaluation Results: Out 26 high-quality studies, findings reveal superior compared oil. Specifically, above 3000 mg, re-esterified triacylglycerol or ethyl ester formulations (100-2900 mg), (100-1900 mg) significantly enhanced index. At lower dosages (under 2000 shows absorption Using at doses 2900 mg may be for reducing Tmax. However, this finding should interpreted with caution due high heterogeneity limited statistical significance. highest AUC values were observed phospholipid/free acid formulation. Emulsion more increasing Cmax than other formulations. These results supported by robust evidence (Egger's test, p > 0.05), highlighting effectiveness specific optimizing absorption. Conclusion: research highlights importance understanding suggest that low-dose emulsions potentially safer alternatives high-dose oil, minimizing adverse effects.

Language: Английский

Citations

2
Omega-3 polyunsaturated fatty acids in depression: insights from recent clinical trials DOI
Simon C. Dyall, Ikbal Andrian Malau,

Kuan-Pin Su

et al.

Current Opinion in Clinical Nutrition & Metabolic Care, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 24, 2024

This review examines evidence from recent clinical trials on the therapeutic potential of omega-3 polyunsaturated fatty acids (PUFAs) in major depressive disorder (MDD). We focus effects MDD with comorbidities, younger populations, and high-inflammation presentations. PubMed, Cochrane, Embase databases were systematically searched for studies published between May 2022 2024. The search was conducted randomized controlled using PUFAs participants a diagnosis depression.Higher doses eicosapentaenoic acid (EPA) (>1 g/day) improved measures depression, particularly elevated inflammation markers, comorbid cardiovascular diseases, late-life onset, children adolescent populations. Improvements symptoms associated increases PUFA-derived anti-inflammatory proresolving lipid mediators. As adjuvant treatments, have benefits mood, cognitive metabolic functions, kynurenine serotonin pathways, alterations corticolimbic functional connectivity. While suggests promise, high-dose EPA inflammatory subtypes, more research is needed to establish optimal dosing regimens, treatment duration, patient subgroups most likely benefit. Future should sex differences, long-term effects, synergies other treatments.

Language: Английский

Citations

1
Comparison of Omega-3 Polyunsaturated Fatty Acids Bioavailability in Fish Oil and Krill Oil: Network Meta-Analyses DOI
Thi-Phuong-Thao Pham, Thi-Van Hoang,

Phuc-Thao-Nguyen Cao

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

1
Comparative Bioavailability of Omega-3 Polyunsaturated Fatty Acids in Fish Oil and Krill Oil: A Network Meta-Analysis DOI
Thi-Phuong-Thao Pham,

Phuc-Thao-Nguyen Cao,

Thi-Thuy-Duong Le

et al.

SSRN Electronic Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Background and aims: Despite the known health benefits of Omega-3 polyunsaturated fatty acids (PUFAs), comparative bioavailability these nutrients from fish oil (FO) krill (KO) remains inadequately explored. This study addresses gap by evaluating various forms doses PUFAs in FO KO, utilizing a network meta-analysis approach.Methods: The adhered to PRISMA 2015 guidelines. risk bias was evaluated using PEDro scale. incorporated data studies published between 1993 2023, analyzed different assessing daily categorized into three levels based on their DHA+EPA content. Statistical analysis conducted advanced models R software ensure rigorous evaluation bioavailability. PROSPERO ID: CRD42024532536.Results: Out 40 high-quality studies, findings this reveal superior KO compared at equivalent doses. Specifically, above 3000 mg, re-esterified triacylglycerol (100 - 4000 mg) ethyl ester (2000 significantly enhanced levels, DHA EPA, with highest AUC values observed phospholipid/free acid form 1900 emulsion mg). These results were supported robust statistical evidence (Egger's test, p > 0.05), highlighting effectiveness specific formulations optimizing absorption. Conclusion: is first systematically compare across wide range Notably, higher FO, specifically those exceeding such as ranging 100 2900 have shown effectively enhance O3i, DHA, EPA; although focused low mg. Future research should further investigate dose-response relationship oils better inform clinical dietary

Language: Английский

Citations

0
Dietary omega-3 intake and cognitive function in older adults DOI
Bingdian Wang,

D. Li,

Cuicui Peng

et al.

The International Journal of Psychiatry in Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 15, 2024

Objective Dietary habits have long been known to be a critical factor influencing cognitive health, especially among older adults. Despite extensive research on various dietary components, the impact of omega-3 polyunsaturated fatty acids (PUFAs) function has not yet thoroughly investigated. This seeks determine whether more intake PUFAs correlates with improved in Methods Data were analyzed from National Health and Nutrition Examination Survey (NHANES), which included 2430 elderly participants aged 60 above. The association between consumption outcomes was evaluated using linear regression models. Smoothing curves threshold effect analysis employed examine nonlinear associations. Subgroup studies conducted demonstrate strength reliability correlation factors affecting them. Results fully adjusted model demonstrated significant positive correlations scores all 3 assessments performed. Specifically, final model, beta coefficients for CERAD Word Learning test, Animal Fluency Test, Digit Symbol Substitution Test 0.53 (95% CI: 0.33-0.72; P < 0.0001), 0.29 0.12-0.47; = 0.001), 0.61 0.19-1.03; 0.0045), respectively. Conclusion Increased positively independently associated adults, suggesting that may help prevent decline aging. Prospective are needed direct this association.

Language: Английский

Citations

0