Improving Social and Personal Rhythm Dysregulation in Young and Old Adults with Bipolar Disorder: Post-Hoc Analysis of a Feasibility Randomized Controlled Trial Using Virtual Reality-Based Intervention
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(13), С. 3786 - 3786
Опубликована: Июнь 27, 2024
Introduction:
Rehabilitative
interventions
employing
technology
play
a
crucial
role
in
bipolar
disorder
(BD)
treatment.
The
study
aims
to
appraise
the
virtual
reality
(VR)-based
cognitive
remediation
(CR)
and
interpersonal
rhythm
approaches
treatment
outcomes
of
BD
across
different
age
groups.
Methods:
Post-hoc
analysis
12-week
randomizedcontrolled
cross-over
feasibility
trial
involving
people
with
mood
disorders
(BD,
DSM-IV)
aged
18–75
years
old:
thirty-nine
exposed
experimental
VR-based
CR
vs
25
waiting
list
controls.
People
relapse,
epilepsy
or
severe
eye
diseases
(due
potential
VR
risks
exposure)
were
excluded.
Biological
Rhythms
Interview
Assessment
Neuropsychiatry
(BRIAN)
was
used
measure
outcome.
Results:
Cases
controls
did
not
statistically
significantly
differ
sex
distributions.
Personal
scores
improved
over
follow-up
control
group
(APC
=
8.7%;
F
111.9;
p
<
0.0001),
both
young
(18–45
years)
5.5%;
70.46;
0.0001)
and,
lesser
extent,
older
(>46
adults
10.5%;
12.110;
0.002).
Conclusions:
This
observed
synchronization
personal
social
rhythms
individuals
after
intervention,
particularly
activity,
daily
activities,
chronotype,
greater
benefits
younger
population.
Язык: Английский
Co-morbid cannabis use disorder and chronotype are associated with mood symptom onset in people with bipolar disorder
Journal of Psychiatric Research,
Год журнала:
2024,
Номер
180, С. 327 - 332
Опубликована: Ноя. 4, 2024
Comorbid
cannabis
use
disorder
(CUD)
is
disproportionately
high
in
people
with
bipolar
(BD)
and
has
been
associated
worsening
of
BD
symptoms.
However,
many
report
regularly
using
to
ameliorate
symptoms,
including
sleep
disturbances.
Sleep
circadian
rhythm
disturbances
are
hallmark
features
that
often
precede
the
onset
mood
Genetic
studies
indicate
disruption
may
predispose
individuals
towards
both
problematic
BD,
rather
than
directly
impacting
To
further
disentangle
these
hypotheses,
we
aimed
investigate
relationship
between
chronotype,
Data
from
212
participants
I
Pharmacogenomics
Bipolar
Disorder
study
dataset
were
analyzed
for
this
study.
Participants
stratified
by
those
diagnosed
co-morbid
CUD
symptom
variables,
mean
number
episodes
per
year
age
depression
mania
The
Basic
Language
Morningness
scale
(BALM)
was
used
assess
chronotype.
There
no
interaction
morningness
levels
on
however
lower
independently
earlier
onset.
patients
who
reported
initiating
post
had
an
compared
prior
These
findings
could
provide
evidence
be
underlying
factor
predisposes
toward
BD.
Язык: Английский