The Influence of Cecal Microbiota Transplantation on Chicken Injurious Behavior: Perspective in Human Neuropsychiatric Research
Biomolecules,
Год журнала:
2024,
Номер
14(8), С. 1017 - 1017
Опубликована: Авг. 16, 2024
Numerous
studies
have
evidenced
that
neuropsychiatric
disorders
(mental
illness
and
emotional
disturbances)
with
aggression
(or
violence)
pose
a
significant
challenge
to
public
health
contribute
substantial
economic
burden
worldwide.
Especially,
social
disorganization
inequality)
associated
childhood
adversity
has
long-lasting
effects
on
mental
health,
increasing
the
risk
of
developing
disorders.
Intestinal
bacteria,
functionally
as
an
endocrine
organ
second
brain,
release
various
immunomodulators
bioactive
compounds
directly
or
indirectly
regulating
host’s
physiological
behavioral
homeostasis.
Under
challenges,
stress-induced
dysbiosis
increases
gut
permeability
causes
serial
reactions:
releasing
neurotoxic
compounds,
leading
neuroinflammation
neuronal
injury,
eventually
aggressive,
violent,
impulsive
behavior
in
humans
animals
via
complex
bidirectional
communication
microbiota–gut–brain
(MGB)
axis.
The
dysregulation
MGB
axis
also
been
recognized
one
reasons
for
prevalence
injurious
behaviors
(feather
pecking,
aggression,
cannibalistic
pecking)
chickens.
However,
existing
knowledge
preventing
treating
these
both
chickens
is
not
well
understood.
In
previous
studies,
we
developed
non-mammal
model
abnormal
investigation
by
rationalizing
microbiota
Based
our
earlier
success,
perspective
article
outlines
possibility
reducing
through
modifying
cecal
transplantation,
potential
providing
biotherapeutic
rationale
among
individuals
restoring
diversity
function.
Язык: Английский
Targeting the gut microbiota-inflammation-brain axis as a potential therapeutic strategy for psychiatric disorders: A Mendelian randomization analysis
Journal of Affective Disorders,
Год журнала:
2025,
Номер
374, С. 150 - 159
Опубликована: Янв. 13, 2025
Язык: Английский
Proteome-wide Mendelian randomization and colocalization analysis identify therapeutic targets for cutaneous melanoma
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Март 11, 2025
Abstract
Background:
Cutaneous
melanoma
(CM)
is
the
deadliest
form
of
skin
cancer.
Mendelian
randomization
(MR)
and
local
analysis
have
been
widely
used
in
search
for
therapeutic
targets
diseases.
Methods:
Plasma
proteins
data
were
obtained
from
UK
Biobank
Pharmaceutical
Proteomics
Project
(UKB-PPP)
database.
The
GWAS
CM
extracted
Finnish
(R10)
Proteome-wide
MR
to
assess
causal
relationship
between
plasma
CM.
Colocalization
was
identify
variants
shared
A
phenotype-wide
association
study
(PheWAS)
potential
adverse
effects
that
could
treat
on
2480
phenotypes
Results:
revealed
5,6-hydroxyindole-2-carboxylate
oxidase
(TYRP1)
(OR:
0.23,
95%
CI:
0.12-0.44)
dipeptidase
1(DPEP1)
0.63,
associated
with
evidence
colocalization
supported
an
inverse
DPEP1
levels
risk
CM,
but
TYRP1
low
grade.
PheWAS
suggested
as
a
target
may
cause
dementia.
Conclusions:
Our
investigation
examined
relationships
two
providing
comprehensive
understanding
targets.
Язык: Английский
Unlocking the mind-gut connection: Impact of human microbiome on cognition
Cell Host & Microbe,
Год журнала:
2024,
Номер
32(8), С. 1248 - 1263
Опубликована: Авг. 1, 2024
Язык: Английский
Ageing, Proteostasis, and the Gut: Insights into Neurological Health and Disease
Ageing Research Reviews,
Год журнала:
2024,
Номер
unknown, С. 102504 - 102504
Опубликована: Сен. 1, 2024
Язык: Английский
Uncovering Molecular and Genetic Drivers of Dental Caries Via scRNA-seq and Mendelian Randomisation
International Dental Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 1, 2024
Dental
caries
remains
a
prevalent
oral
health
problem
globally,
influenced
by
environmental,
genetic,
and
microbial
factors.
Traditional
studies
have
emphasised
colonisation
dietary
sugars,
neglecting
the
intricate
molecular
genetic
interactions.
This
study
aimed
to
integrate
single-cell
RNA
sequencing
(scRNA-seq)
with
Mendelian
randomisation
(MR)
elucidate
factors
contributing
susceptibility
progression
of
dental
caries.
Язык: Английский
Exerkine irisin mitigates cognitive impairment by suppressing gut-brain axis-mediated inflammation
Journal of Advanced Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 1, 2024
Язык: Английский
An approach to finding specific forms of dysbiosis that associate with different disorders
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 25, 2024
Abstract
Background
Many
disorders
display
dysbiosis
of
the
enteric
microbiome,
compared
with
healthy
controls.
Different
share
a
pattern
that
may
reflect
‘reverse
causation’,
due
to
non-specific
effects
illness-in-general.
Combining
range
into
an
‘aggregate
non-healthy
active
control’
(ANHAC)
group
should
highlight
such
dysbiosis.
Differential
between
ANHAC
and
specific
then
treatment
or
bowel
dysfunction,
potentially
be
causal.
Here,
we
illustrate
this
logic
by
testing
if
individual
genera
can
differentiate
from
two
diagnostic
groups.
Methods
We
constructed
ANAHC
(n=17)
had
14
different
disorders.
used
random
forest
analyses
test
differential
other
have
no
known
pathology,
but:
(i)
symptoms
illness
(Myalgic
Encephalomyelitis
/
Chronic
Fatigue
Syndrome
–
ME/CFS
n
=
38);
(ii)
both
dysfunction
(ME/CFS
comorbid
Irritable
Bowel
IBS
n=27).
Results
differentiated
co-morbid
IBS.
However,
only
-
Roseburia
Dialister
discriminated
ME/CFS.
Conclusions
associate
forms
dysbiosis,
over-and-above
contribute
in
via
reverse
causation.
has
illness-in-general,
but
lacks
pathology
definitive
could
cause
Therefore,
[230
words]
Contribution
field
The
is
largely
consistent
unrelated
disorders,
which
suggests
it
mainly
reflects
secondary
illness-in-general
(e.g.
changes
activity
levels,
diet).
faecal
microbiome
transplantation
(FMT)
therapeutic
some
This
implies
unique
features
those
propose
way
assess
causal
discriminate
group.
Dysbiosis
control
for
on
so
potentially-causal
approach
provide
insight
pathogenetic
mechanisms
help
design
FMT
counteract
them.
Язык: Английский