An approach to finding specific forms of dysbiosis that associate with different disorders DOI Creative Commons
Jonathan Williams, Inga Williams, Karl Morten

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 25, 2024

Abstract Background Many disorders display dysbiosis of the enteric microbiome, compared with healthy controls. Different share a pattern that may reflect ‘reverse causation’, due to non-specific effects illness-in-general. Combining range into an ‘aggregate non-healthy active control’ (ANHAC) group should highlight such dysbiosis. Differential between ANHAC and specific then treatment or bowel dysfunction, potentially be causal. Here, we illustrate this logic by testing if individual genera can differentiate from two diagnostic groups. Methods We constructed ANAHC (n=17) had 14 different disorders. used random forest analyses test differential other have no known pathology, but: (i) symptoms illness (Myalgic Encephalomyelitis / Chronic Fatigue Syndrome – ME/CFS n = 38); (ii) both dysfunction (ME/CFS comorbid Irritable Bowel IBS n=27). Results differentiated co-morbid IBS. However, only - Roseburia Dialister discriminated ME/CFS. Conclusions associate forms dysbiosis, over-and-above contribute in via reverse causation. has illness-in-general, but lacks pathology definitive could cause Therefore, [230 words] Contribution field The is largely consistent unrelated disorders, which suggests it mainly reflects secondary illness-in-general (e.g. changes activity levels, diet). faecal microbiome transplantation (FMT) therapeutic some This implies unique features those propose way assess causal discriminate group. Dysbiosis control for on so potentially-causal approach provide insight pathogenetic mechanisms help design FMT counteract them.

Language: Английский

The Influence of Cecal Microbiota Transplantation on Chicken Injurious Behavior: Perspective in Human Neuropsychiatric Research DOI Creative Commons
Yuechi Fu, H.W. Cheng

Biomolecules, Journal Year: 2024, Volume and Issue: 14(8), P. 1017 - 1017

Published: Aug. 16, 2024

Numerous studies have evidenced that neuropsychiatric disorders (mental illness and emotional disturbances) with aggression (or violence) pose a significant challenge to public health contribute substantial economic burden worldwide. Especially, social disorganization inequality) associated childhood adversity has long-lasting effects on mental health, increasing the risk of developing disorders. Intestinal bacteria, functionally as an endocrine organ second brain, release various immunomodulators bioactive compounds directly or indirectly regulating host’s physiological behavioral homeostasis. Under challenges, stress-induced dysbiosis increases gut permeability causes serial reactions: releasing neurotoxic compounds, leading neuroinflammation neuronal injury, eventually aggressive, violent, impulsive behavior in humans animals via complex bidirectional communication microbiota–gut–brain (MGB) axis. The dysregulation MGB axis also been recognized one reasons for prevalence injurious behaviors (feather pecking, aggression, cannibalistic pecking) chickens. However, existing knowledge preventing treating these both chickens is not well understood. In previous studies, we developed non-mammal model abnormal investigation by rationalizing microbiota Based our earlier success, perspective article outlines possibility reducing through modifying cecal transplantation, potential providing biotherapeutic rationale among individuals restoring diversity function.

Language: Английский

Citations

5
Targeting the gut microbiota-inflammation-brain axis as a potential therapeutic strategy for psychiatric disorders: A Mendelian randomization analysis DOI

Wenjing Wu,

Shuhan Li, Zengjie Ye

et al.

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: 374, P. 150 - 159

Published: Jan. 13, 2025

Language: Английский

Citations

0
Proteome-wide Mendelian randomization and colocalization analysis identify therapeutic targets for cutaneous melanoma DOI Creative Commons
Wenjing Luo, Di Zhou, Fang He

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Abstract Background: Cutaneous melanoma (CM) is the deadliest form of skin cancer. Mendelian randomization (MR) and local analysis have been widely used in search for therapeutic targets diseases. Methods: Plasma proteins data were obtained from UK Biobank Pharmaceutical Proteomics Project (UKB-PPP) database. The GWAS CM extracted Finnish (R10) Proteome-wide MR to assess causal relationship between plasma CM. Colocalization was identify variants shared A phenotype-wide association study (PheWAS) potential adverse effects that could treat on 2480 phenotypes Results: revealed 5,6-hydroxyindole-2-carboxylate oxidase (TYRP1) (OR: 0.23, 95% CI: 0.12-0.44) dipeptidase 1(DPEP1) 0.63, associated with evidence colocalization supported an inverse DPEP1 levels risk CM, but TYRP1 low grade. PheWAS suggested as a target may cause dementia. Conclusions: Our investigation examined relationships two providing comprehensive understanding targets.

Language: Английский

Citations

0
Unlocking the mind-gut connection: Impact of human microbiome on cognition DOI
Anna Castells‐Nobau, Jordi Mayneris‐Perxachs, José Manuel Fernández‐Real

et al.

Cell Host & Microbe, Journal Year: 2024, Volume and Issue: 32(8), P. 1248 - 1263

Published: Aug. 1, 2024

Language: Английский

Citations

3
Ageing, Proteostasis, and the Gut: Insights into Neurological Health and Disease DOI

Mahmood Akbar,

Pranoy Toppo,

Aamir Nazir

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102504 - 102504

Published: Sept. 1, 2024

Language: Английский

Citations

1
Uncovering Molecular and Genetic Drivers of Dental Caries Via scRNA-seq and Mendelian Randomisation DOI Creative Commons
Jian Wang, Yu Zhou,

William Xu

et al.

International Dental Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Dental caries remains a prevalent oral health problem globally, influenced by environmental, genetic, and microbial factors. Traditional studies have emphasised colonisation dietary sugars, neglecting the intricate molecular genetic interactions. This study aimed to integrate single-cell RNA sequencing (scRNA-seq) with Mendelian randomisation (MR) elucidate factors contributing susceptibility progression of dental caries.

Language: Английский

Citations

1
Exerkine irisin mitigates cognitive impairment by suppressing gut-brain axis-mediated inflammation DOI Creative Commons
Hu Zhang, Jiling Liang,

Jielun Huang

et al.

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

0
An approach to finding specific forms of dysbiosis that associate with different disorders DOI Creative Commons
Jonathan Williams, Inga Williams, Karl Morten

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 25, 2024

Abstract Background Many disorders display dysbiosis of the enteric microbiome, compared with healthy controls. Different share a pattern that may reflect ‘reverse causation’, due to non-specific effects illness-in-general. Combining range into an ‘aggregate non-healthy active control’ (ANHAC) group should highlight such dysbiosis. Differential between ANHAC and specific then treatment or bowel dysfunction, potentially be causal. Here, we illustrate this logic by testing if individual genera can differentiate from two diagnostic groups. Methods We constructed ANAHC (n=17) had 14 different disorders. used random forest analyses test differential other have no known pathology, but: (i) symptoms illness (Myalgic Encephalomyelitis / Chronic Fatigue Syndrome – ME/CFS n = 38); (ii) both dysfunction (ME/CFS comorbid Irritable Bowel IBS n=27). Results differentiated co-morbid IBS. However, only - Roseburia Dialister discriminated ME/CFS. Conclusions associate forms dysbiosis, over-and-above contribute in via reverse causation. has illness-in-general, but lacks pathology definitive could cause Therefore, [230 words] Contribution field The is largely consistent unrelated disorders, which suggests it mainly reflects secondary illness-in-general (e.g. changes activity levels, diet). faecal microbiome transplantation (FMT) therapeutic some This implies unique features those propose way assess causal discriminate group. Dysbiosis control for on so potentially-causal approach provide insight pathogenetic mechanisms help design FMT counteract them.

Language: Английский

Citations

0