Neuroprotective Herbs for the Management of Alzheimer’s Disease

Biomolecules, Год журнала: 2021, Номер 11(4), С. 543 - 543

Опубликована: Апрель 8, 2021

Background-Alzheimer's disease (AD) is a multifactorial, progressive, neurodegenerative that characterized by memory loss, personality changes, and decline in cognitive function. While the exact cause of AD still unclear, recent studies point to lifestyle, diet, environmental, genetic factors as contributors progression. The pharmaceutical approaches developed date do not alter More than two hundred promising drug candidates have failed clinical trials past decade, suggesting its causes may be highly complex. Medicinal plants herbal remedies are now gaining more interest complementary alternative interventions valuable source for developing AD. Indeed, several scientific described use various medicinal their principal phytochemicals treatment This article reviews subset herbs anti-inflammatory, antioxidant, cognitive-enhancing effects. Methods-This systematically investigated role neuroprotective bioactive compounds dementia associated with Alzheimer's pre-Alzheimer's disease. PubMed Central, Scopus, Google Scholar databases articles were collected, abstracts reviewed relevance subject matter. Conclusions-Medicinal great potential part an overall program prevention It hoped these can used discovery programs identifying safe efficacious small molecules

Язык: Английский

---

Traditional fermented foods with anti-aging effect: A concentric review

Food Research International, Год журнала: 2020, Номер 134, С. 109269 - 109269

Опубликована: Апрель 23, 2020

Язык: Английский

---

Immunosenescence and Inflamm-Aging: Clinical Interventions and the Potential for Reversal of Aging

Cureus, Год журнала: 2024, Номер unknown

Опубликована: Янв. 31, 2024

Inflammation is often associated with the impairment of ability to sustain consequences physical, chemical, nutritional, and antigenic triggers inflammation. The process immunosenescence may only partially be explained by senescence cells, tissues, or organism, and, hence, hallmarks markedly differentially affected history an individual's pathogenic encounter. a key component immunosenescence, which itself direct consequence aging. This review article highlights therapeutic interventions for slowing processes inflamm-aging possible reversal aging includes domains immunomodulatory interventions, vaccination strategies, nutritional stem cell therapies, personalized medicine, microbiome positive effects physical activity exercise.

Язык: Английский

---

An Ayurgenomics Approach: Prakriti-Based Drug Discovery and Development for Personalized Care

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Апрель 1, 2022

Originating in ancient India, Ayurveda is an alternative medicinal approach that provides substantial evidence for a theoretical-level analysis of all aspects life. Unlike modern medicine, based upon tridoshas ( Vata, pitta, and Kapha ) Prakriti. On the other hand, research genes involved at proteomics, metabolomics, transcriptome levels are referred to as genomics . Geoclimatic regions (deshanupatini), familial characteristics (kulanupatini), ethnicity (jatiprasakta) have been shown affect phenotypic variability. The combination with known ayurgenomics provided new insights into tridosha may pave way precision medicine (personalized medicine). Through successful coordination “omics,” Prakriti -based treatments can help change existing situation health care. refers individual’s behavioral trait, which established moment birth cannot be fully altered during one’s existence. Ayurvedic methodologies on three aspects: aushadhi (medication), vihara (lifestyle), ahara (diet). A foundation preventative improvement life quality longevity accomplished through these ayurvedic characteristics. In this perspective, we try understand prakriti’s use personalized how integrate it programs drug development discovery.

Язык: Английский

---

Traditional medicine herbs as natural product matrices in cancer chemoprevention: A trans pharmacological perspective (scoping review)

Phytotherapy Research, Год журнала: 2023, Номер 37(4), С. 1539 - 1573

Опубликована: Фев. 14, 2023

Abstract Emerging evidence on molecular biology related to tumors, inflammation, and immunity, highlights their architectural commonality shifting cancer treatment paradigms toward more economical prevention than treatment. Statistical surveys reveal exponentially growing herbal drug supplementation in worldwide as vast pre‐clinical clinical data unravel multi‐mechanistic pharmacology. The integrative oncological approach calls for “holistic” principles be amalgamated into care. New development from herbs need not limited by the archetypal ‘RCT‐Standardization’ bottlenecks. Based comprehensive literature scoping per Prisma‐ScR guidelines, we herein concurrently reviewed evidence‐based research reports of selected Indian Traditional Medicine (ITM) anticancer repute parallel with holistic therapeutics; a rationalistic exploration ITM's scientific genre. Their synergy effect revisited using trans‐pharmacological validates seemingly simplistic health/disease equation model, showing fresh new avenue re‐purposing whole complexes management. Herbal drugs ITM are natural matrices whose dynamics interaction etiopathology conceptually mechanistically integrative. Lateral perspective same laid out this review holds key effectual tangible chemopreventives/new targets/leads if pharmacological tools.

Язык: Английский

---

Involvement of mitochondria in Alzheimer’s disease pathogenesis and their potential as targets for phytotherapeutics

Mitochondrion, Год журнала: 2024, Номер 76, С. 101868 - 101868

Опубликована: Март 9, 2024

Alzheimer's disease (AD) is the leading cause of dementia around globe. The disease's genesis multifaceted, and its pathophysiology complicated. Malfunction mitochondria has been regarded as one intracellular events that are substantially damaged in onset AD likely a common trait other neurodegenerative illnesses. Several mitochondrial characteristics begin to diminish with age, eventually reaching state significant functional failure concurrent beginning diseases, however, exact timing these processes unknown. Mitochondrial malfunction multitude negative repercussions, including reduced calcium buffering secondary excitotoxicity contributing synaptic dysfunction, also free radical production, activation permeability transition. Hence considered therapeutic target disorders such Alzheimer's. Traditional medicinal systems practiced different countries employing various plants postulated have potent role therapy management memory impairment amnesia, well AD. Although, chemical assessment clinical studies using or plant products demonstrated efficacy for AD, precise mechanism action still obscure. Therefore, this review discusses contribution towards pathogenesis considering phytotherapeutics potential strategy.

Язык: Английский

---

Efficacy and Tolerability of Ashwagandha Root Extract in the Elderly for Improvement of General Well-being and Sleep: A Prospective, Randomized, Double-blind, Placebo-controlled Study

Cureus, Год журнала: 2020, Номер unknown

Опубликована: Фев. 23, 2020

Background Ashwagandha is an excellent adaptogen that being used since ancient times in Ayurvedic medicine. Traditionally, it for various ailments and general well-being, including the treatment of geriatric patients. Managing quality life (QoL) remains a challenge elderly population, especially joint pain management, sleep, well-being. With growing global QoL management with efficient medication supplementation major healthcare requirement. Objective The objective this study was to assess safety, efficacy, tolerability (Withania somnifera (L.) Dunal.) root extract on improvement health sleep people. Methods This 12-week, prospective, randomized, double-blind, placebo-controlled conducted individuals either gender aged between 65-80 years. Participants were randomized receive at dose 600 mg/day (n = 25) orally, or identical placebo capsules same 12 weeks. Efficacy assessed using WHOQOL-BREF questionnaire, quality, mental alertness rising, Physician's Global Assessment Therapy (PGAET). safety clinical adverse events reporting Patient's Tolerability (PGATT). Results Statistically significant (P<0.0001) observed group compared placebo. mean (SD) total score improved from 140.53 (8.25) baseline 161.84(9.32) end study. individual domain scores also improved. At baseline, rising comparatively low both groups. However, upon intervention, increase (P<0.034) when group. Overall wellbeing, population. experimental population displayed good test product reported as safe beneficial by participants. Conclusion outcomes suggest improving QoL, self-assessed recommended could be effective

Язык: Английский

---

Predicting Ayurveda-Based Constituent Balancing in Human Body Using Machine Learning Methods

IEEE Access, Год журнала: 2020, Номер 8, С. 65060 - 65070

Опубликована: Янв. 1, 2020

Human Body constitution ( prakriti ) defines what is in harmony with human nature and will cause to move out of balance experience illness. xmlns:xlink="http://www.w3.org/1999/xlink">Tridosha the three basic energies or principles that determine function our body on physical emotional levels. The are known as xmlns:xlink="http://www.w3.org/1999/xlink">VATT , xmlns:xlink="http://www.w3.org/1999/xlink">PITT xmlns:xlink="http://www.w3.org/1999/xlink">KAPH . Each individual has a unique all these energies. Some people be predominant one, while others mixture two more. xmlns:xlink="http://www.w3.org/1999/xlink">Ayurveda-dosha studies have been used for long time, but quantitative reliability measurement diagnostic methods still lags behind. A careful appropriate analysis leads an effective treatment. To collect meaningful data set, questionnaire 28 different characteristics validated by Ayurveda experts. Authors calculate Cronbach alpha xmlns:xlink="http://www.w3.org/1999/xlink">VATT-Dosha xmlns:xlink="http://www.w3.org/1999/xlink">PITT-Dosha xmlns:xlink="http://www.w3.org/1999/xlink">KAPH-Dosha 0.94, 0.98 0.98, respectively check questionnaire. analyzed questionnaires 807 healthy persons aged 20-60 years found 62.1% men 37.9% women. class imbalance problem resolved oversampling equally distributed set randomly selected 405 actual experiment. Using computer algorithms, we divide (8:2) into training 324 test 81 persons. Model trained using traditional machine learning techniques classification Artificial Neural Network (ANN), K-Nearest Neighbour (KNN), Support Vector Machine (SVM), Naive Bayes (NB) Decision Tree (DT). System also implemented ensemble several recognition. Evaluation measures such root mean square error (RMSE), precision, recall, F-score, accuracy calculated analyzed. On analyzing results authors find best tested CatBoost, which tuned hyper parameters achieves 0.96 0.95 F-score rate. experimental result shows proposed model based clearly surpasses conventional methods. conclude advances boosting algorithms could give leading future.

Язык: Английский

---

Unlocking the role of Herbal Cosmeceutical in Anti-ageing and Skin Ageing Associated Diseases

Cutaneous and Ocular Toxicology, Год журнала: 2024, Номер 43(3), С. 211 - 226

Опубликована: Июль 2, 2024

The process of skin ageing is a natural biological phenomenon characterised by the emergence wrinkles, age spots, sagging skin, and dryness over time. increasing significance in physical attractiveness has heightened skincare concerns. Anti-ageing cosmetics play pivotal role nurturing enhancing its quality, promoting overall health. Today, have evolved beyond mere aesthetics are now integral to individual wellness. contemporary quest for perpetual youth intensified, prompting deeper exploration into process. This comprehensive delves various elements involved ageing, encompassing cells such as stem endothelial cells, blood vessels, soft tissues, signalling pathways. molecular basis including biochemical factors like reactive oxygen species, damaged DNA, free radicals, ions, proteins (mRNA), scrutinised alongside relevant animal models. article critically analyzes outcomes utilising herbal components, emphasising their advantageous anti-ageing properties. contributing mechanistic perspectives, management approaches involving cosmeceutical, associated complications (especially cardiovascular diseases, Parkinson's, Alzheimer's, etc.) succinctly addressed. In addition, manuscript further summarises recent patented innovations toxicity cosmeceuticals disorders. Despite progress, research imperative unlock full potential components agents.

Язык: Английский

---

From kitchen to clinic: Pharmacotherapeutic potential of common spices in Indian cooking in age-related neurological disorders

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Ноя. 10, 2022

Aging is described as an advanced time-related collection of changes that may negatively affect with the risk several diseases or death. a main factor age-related neurological disorders, including neurodegenerative (Alzheimer’s disease, Parkinson’s and dementia), stroke, neuroinflammation, neurotoxicity, brain tumors, oxidative stress, reactive oxygen species (ROS). Currently available medications for disorders lead to side effects, such headache, diarrhea, nausea, gastrointestinal (GI) diseases, dyskinesia, hallucinosis. These days, studies on plant efficacy in traditional medicine are being conducted because herbal affordable, safe, culturally acceptable easily accessible. The Indian system called Ayurveda uses herbs medicinal plants treat various disorders. This review aims summarize data neuroprotective potential following common spices widely used Ayurveda: cumin ( Cuminum cyminum (L.), Apiaceae), black Nigella sativa Ranunculaceae), pepper Piper nigrum Piperaceae), curry leaf tree Murraya koenigii Spreng Rutaceae), fenugreek Trigonella foenum-graecum Fabaceae), fennel Foeniculum vulgare Mill, cardamom Elettaria cardamomum (L.) Maton, Zingiberaceae), cloves Syzygium aromaticum Merr. &amp; L.M.Perry, Myrtaceae), coriander Coriandrum sativum Apiaceae)

Язык: Английский

---