The Interplay of Nutrition, the Gut Microbiota and Immunity and Its Contribution to Human Disease

Biomedicines, Год журнала: 2025, Номер 13(2), С. 329 - 329

Опубликована: Янв. 31, 2025

Nutrition, the gut microbiota and immunity are all important factors in maintenance of health. However, there is a growing realization complex interplay between these elements coalescing nutrition-gut microbiota-immunity axis. This regulatory axis critical for health with disruption being implicated broad range diseases, including autoimmune disorders, allergies mental disorders. new perspective continues to underpin number innovative therapeutic strategies targeting different this treat relevant diseases. review describes inter-relationships nutrition, immunity. It then details several human diseases where has been identified presents examples how various may be targeted therapeutically as alternate treatment

Язык: Английский

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Depression and anxiety in patients with atopic dermatitis

Annals of Allergy Asthma & Immunology, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Hope and Team Medicine

The Journal of Allergy and Clinical Immunology In Practice, Год журнала: 2024, Номер 12(10), С. 2646 - 2647

Опубликована: Июль 6, 2024

Язык: Английский

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Lung-specific SFTPC mutations lead to neurodevelopmental disorders with neuroinflammation

Biochemical and Biophysical Research Communications, Год журнала: 2025, Номер 753, С. 151479 - 151479

Опубликована: Фев. 11, 2025

Язык: Английский

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SOMATIC AND PSYCHOSOMATIC PATHOLOGY INTERFERENCE IN MEDICAL REHABILITATION

Romanian Journal of Medical Rehabilitation Physical Medicine and Balneoclimatology, Год журнала: 2025, Номер 1(3), С. 192 - 200

Опубликована: Фев. 15, 2025

The need for knowledge of the field in context MR, underdiagnosis mixed pathology situations, slow evolution, fear disease and slide towards extreme virtual situations are reasons to understand much better pathological provide customized solutions with case application. In history medical studies, psychosomatic conception has presented few but extremely fast dynamic last two centuries, through acquisition applied knowledge. A lot studies try define PS there numerous questions related causality some sufferings. It remains a situation that still faces many clinical cases. These require presentation agora, multitude data, repeatability connection somatic, both theoretical practical recognition definition diagnostic establishment an adapted therapeutic conduct. rehabilitation, somatic-psychological interference occurs frequently major impact evolution recovery aspects. From point view it is difficult take into account psycho-behavioral level clinical-functional analysis decision diagnosis. justification objectives cores confusions stage results targets QoL, defined by five criteria, three them being level.

Язык: Английский

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Genomic Structural Equation Modeling Elucidates the Shared Genetic Architecture of Allergic Disorders

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Background The intricate shared genetic architecture underlying allergic disorders—including asthma, atopic dermatitis, contact rhinitis, conjunctivitis, urticaria, anaphylaxis, and eosinophilic esophagitis—remains incompletely characterized. Methods Our study employed genomic structural equation modeling (Genomic SEM) to define the common factor representing of disorders. Coupled with diverse post-GWAS analytical methods, we aimed discover susceptible loci investigate associations external traits. Furthermore, explored enriched pathways, cellular layers, elements, investigated putative plasma protein biomarkers. Polygenic risk score (PRS) analyses, leveraging our integrated GWAS data, were conducted assess chromosomal-level for Results A well-fitted SEM revealing We identified a total 2038 genome-wide significant SNP (p < 5e-8), including 31 previously unreported loci. Fine-mapping variants gene sets pinpointed 2 causal candidate genes. Genetic correlation analyses further illuminated multiple traits, notably psychiatric Preliminary findings four Conclusion Notably, this presents first comprehensive characterization disorders through analysis an unmeasured composite phenotype, providing novel insights into etiological pathways across these conditions.

Язык: Английский

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Mental health for the allergist

Annals of Allergy Asthma & Immunology, Год журнала: 2025, Номер 134(5), С. 497 - 498

Опубликована: Май 1, 2025

Язык: Английский

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Bidirectional Relationship Between Atopic Dermatitis and Psychiatric Comorbidities in Individuals of European Ancestry: A Mendelian Randomization Study

Acta Dermato Venereologica, Год журнала: 2025, Номер 105, С. adv43133 - adv43133

Опубликована: Май 15, 2025

Atopic dermatitis is a chronic inflammatory skin disorder that significantly impacts quality of life and often associated with psychiatric comorbidities. How-ever, the causal relationship between atopic disorders remains unclear. This study employed bidirectional 2-sample Mendelian randomization to investigate potential relationships 8 conditions: depression, anxiety, autism spectrum disorder, attention deficit hyperactivity suicidality, bipolar obsessive-compulsive schizophrenia. Genetic instruments were derived from large-scale genome-wide association studies European ancestry. Forward analysis indicated causally increases risk anxiety (inverse variance weighting p = 0.016; odds ratio 1.110, 95% confidence interval: 1.019–1.208). Reverse revealed significant effect on increasing 0.005; 1.062, 1.018–1.107). No found for other conditions. Sensitivity analyses confirmed robustness these findings, no evidence horizontal pleiotropy. These results highlight need integrated dermatological care, emphasizing early mental health screening patients evaluation individuals disorder. Future research should explore underlying biological mechanisms validate findings across diverse populations.

Язык: Английский

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Analysis of Psychological Status and Influencing Factors in Children with Allergic Rhinitis

Advances in Clinical Medicine, Год журнала: 2025, Номер 15(05), С. 1380 - 1389

Опубликована: Янв. 1, 2025

Язык: Английский

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Cost-effectiveness of shared decision-making in determining challenge setting for nonsevere food protein-induced enterocolitis syndrome

Annals of Allergy Asthma & Immunology, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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