Current Opinion in Pediatrics,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 4, 2024
Purpose
of
review
To
share
important
highlights
on
the
management
anaphylaxis
from
latest
2023
practice
parameter.
Recent
findings
The
Allergy
Immunology
Joint
Task
Force
Practice
Parameters
(JTFPP)
parameter
provides
updated
guidance.
Criteria
for
diagnosis
are
reviewed.
that
while
is
not
more
severe
in
younger
children,
age-specific
symptoms
can
vary.
Activation
emergency
medical
services
may
be
required
patients
who
experience
prompt
resolution
following
epinephrine
use
and
caregivers
comfortable
with
observation.
For
children
weighing
<15
kg,
suggests
clinician
prescribe
either
0.1
mg
or
0.15
autoinjector,
0.3
autoinjector
prescribed
those
25
kg
greater.
In
heart
disease,
discontinuing
changing
beta
blockers
and/or
angiotensin
converting
enzyme
inhibitors
pose
a
larger
risk
worsened
cardiovascular
disease
compared
medication
continuation.
Furthermore,
history
perioperative
anaphylaxis,
shared
decision-making
based
diagnostic
testing
clinical
recommended
prior
to
repeat
anesthesia
use.
Beyond
recent
update,
novel
contemporary
therapies
decrease
community
anaphylaxis.
Summary
JTFPP
Anaphylaxis
Guidelines
offer
up-to-date
guidance
infants,
adults.
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(2), P. 329 - 329
Published: Jan. 31, 2025
Nutrition,
the
gut
microbiota
and
immunity
are
all
important
factors
in
maintenance
of
health.
However,
there
is
a
growing
realization
complex
interplay
between
these
elements
coalescing
nutrition-gut
microbiota-immunity
axis.
This
regulatory
axis
critical
for
health
with
disruption
being
implicated
broad
range
diseases,
including
autoimmune
disorders,
allergies
mental
disorders.
new
perspective
continues
to
underpin
number
innovative
therapeutic
strategies
targeting
different
this
treat
relevant
diseases.
review
describes
inter-relationships
nutrition,
immunity.
It
then
details
several
human
diseases
where
has
been
identified
presents
examples
how
various
may
be
targeted
therapeutically
as
alternate
treatment
Journal of Translational Medicine,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: April 15, 2025
The
intricate
shared
genetic
architecture
underlying
allergic
disorders-including
asthma,
atopic
dermatitis,
contact
rhinitis,
conjunctivitis,
urticaria,
anaphylaxis,
and
eosinophilic
esophagitis-remains
incompletely
characterized.
Our
study
employed
genomic
structural
equation
modeling
(Genomic
SEM)
to
define
the
common
factor
representing
of
disorders.
Coupled
with
diverse
post-GWAS
analytical
methods,
we
aimed
discover
susceptible
loci
investigate
associations
external
traits.
Furthermore,
explored
enriched
pathways,
cellular
layers,
elements,
investigated
putative
plasma
protein
biomarkers.
Polygenic
risk
score
(PRS)
analyses,
leveraging
our
integrated
GWAS
data,
were
conducted
assess
chromosomal-level
for
A
well-fitted
SEM
revealing
We
identified
a
total
2038
genome-wide
significant
SNP
(p
<
5e-8),
including
31
previously
unreported
loci.
Fine-mapping
variants
gene
sets
pinpointed
2
causal
candidate
genes.
Genetic
correlation
analyses
further
illuminated
multiple
traits,
notably
psychiatric
Preliminary
findings
four
Notably,
this
presents
first
comprehensive
characterization
disorders
through
analysis
an
unmeasured
composite
phenotype,
providing
novel
insights
into
etiological
pathways
across
these
conditions.
Romanian Journal of Medical Rehabilitation Physical Medicine and Balneoclimatology,
Journal Year:
2025,
Volume and Issue:
1(3), P. 192 - 200
Published: Feb. 15, 2025
The
need
for
knowledge
of
the
field
in
context
MR,
underdiagnosis
mixed
pathology
situations,
slow
evolution,
fear
disease
and
slide
towards
extreme
virtual
situations
are
reasons
to
understand
much
better
pathological
provide
customized
solutions
with
case
application.
In
history
medical
studies,
psychosomatic
conception
has
presented
few
but
extremely
fast
dynamic
last
two
centuries,
through
acquisition
applied
knowledge.
A
lot
studies
try
define
PS
there
numerous
questions
related
causality
some
sufferings.
It
remains
a
situation
that
still
faces
many
clinical
cases.
These
require
presentation
agora,
multitude
data,
repeatability
connection
somatic,
both
theoretical
practical
recognition
definition
diagnostic
establishment
an
adapted
therapeutic
conduct.
rehabilitation,
somatic-psychological
interference
occurs
frequently
major
impact
evolution
recovery
aspects.
From
point
view
it
is
difficult
take
into
account
psycho-behavioral
level
clinical-functional
analysis
decision
diagnosis.
justification
objectives
cores
confusions
stage
results
targets
QoL,
defined
by
five
criteria,
three
them
being
level.
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 1, 2025
Abstract
Background
The
intricate
shared
genetic
architecture
underlying
allergic
disorders—including
asthma,
atopic
dermatitis,
contact
rhinitis,
conjunctivitis,
urticaria,
anaphylaxis,
and
eosinophilic
esophagitis—remains
incompletely
characterized.
Methods
Our
study
employed
genomic
structural
equation
modeling
(Genomic
SEM)
to
define
the
common
factor
representing
of
disorders.
Coupled
with
diverse
post-GWAS
analytical
methods,
we
aimed
discover
susceptible
loci
investigate
associations
external
traits.
Furthermore,
explored
enriched
pathways,
cellular
layers,
elements,
investigated
putative
plasma
protein
biomarkers.
Polygenic
risk
score
(PRS)
analyses,
leveraging
our
integrated
GWAS
data,
were
conducted
assess
chromosomal-level
for
Results
A
well-fitted
SEM
revealing
We
identified
a
total
2038
genome-wide
significant
SNP
(p
<
5e-8),
including
31
previously
unreported
loci.
Fine-mapping
variants
gene
sets
pinpointed
2
causal
candidate
genes.
Genetic
correlation
analyses
further
illuminated
multiple
traits,
notably
psychiatric
Preliminary
findings
four
Conclusion
Notably,
this
presents
first
comprehensive
characterization
disorders
through
analysis
an
unmeasured
composite
phenotype,
providing
novel
insights
into
etiological
pathways
across
these
conditions.
