Mechanisms through which exercise reduces symptom severity and/or functional impairment in posttraumatic stress disorder (PTSD): Protocol for a living systematic review of human and non-human studies

Wellcome Open Research, Год журнала: 2025, Номер 8, С. 494 - 494

Опубликована: Янв. 13, 2025

Background Exercise can play an important role in reducing symptom severity and improving functional impairment patients with posttraumatic stress disorder (PTSD). However, the precise mechanisms underpinning effect of exercise PTSD management are not fully understood. This living systematic review aims to synthesize triangulate evidence from non-human human studies gain insight into biopsychosocial through which reduces impairment. Methods Independent searches will be conducted electronic databases identify eligible studies. Two reviewers independently conduct study selection, data extraction, risk bias assessment. We extract outcome variables that act as modifiers or mediators exercise. For studies, include equivalents clusters. primary severity. The secondary outcomes avoidance severity, reexperiencing hyperarousal negative cognitions mood impairment, loss diagnosis, dropout rates. To explain affects interest, we effects relate impact on potential mediating later outcomes. Comparison within-study direct indirect obtained mediation analysis, when reported, provide importance examined mediator. If appropriate, results using meta-analyses. examine total understand better symptoms function (when possible). about association between PTSD-related considered a consensus meeting sufficient is available. Protocol registration PROSPERO-ID: 453615

Язык: Английский

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Current Treatments for Anxiety and Trauma-Related Disorders

Oxford University Press eBooks, Год журнала: 2025, Номер unknown, С. 571 - 582

Опубликована: Янв. 1, 2025

Abstract Abstract: Anxiety and trauma-related disorders are some of the most commonly occurring mental health conditions have a significant impact on quality life and/or functioning. This chapter highlights evidence-based pharmacotherapy, psychotherapy, integrative interventions for common anxiety disorders, including generalized disorder, social panic post-traumatic stress disorder. First-line generally include selective serotonin reuptake inhibitors serotonin–norepinephrine inhibitors, as well cognitive–behavioral therapy approaches. However, patient preference, resources, access, clinical presentation factors such comorbidity must be considered when selecting treatment. Digital also offer alternatives to increase access scalability interventions. Future directions emphasis processes change mechanisms action, novel augmentation strategies, further optimize personalize disorders.

Язык: Английский

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Group integrated exercise versus recovery class for veterans with posttraumatic stress disorder: a randomized clinical trial

BMC Psychiatry, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 28, 2025

Abstract There are no reported randomized trials testing exercise versus an active comparator for Posttraumatic Stress Disorder (PTSD). This clinical trial assessed the effectiveness of group psychoeducation to improve quality life and reduces symptomatic severity in Veterans with PTSD. who met criteria current PTSD (DSM-5) and/or endorsed moderate levels symptoms (CAPS 5 score ≥ 23) were randomly assigned treatment. Integrative Exercise (IE) combines fitness exercises (aerobics, resistance training, stretching) mindful body/breath awareness Recovery Class (REC) control condition. A total 84 participants enrolled which 41 IE 43 REC. significant pre-post differences change WHOQOL Psychological Domain either group. was a modest reduction CAPS-5 both groups (IE: -8.2 (9.9), p < .001: REC: -7.8 (2.0), .001) but across two conditions. In subsample that remote, there greater improvement symptom (F[1, 50] = 4.62, .036) (F(1, 47) 6.46, .014) those attended more sessions. Trial registration ClinicalTrials.gov Identifier: NCT02856412 (registration date: February 27, 2017).

Язык: Английский

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Aerobic exercise after extinction learning reduces return of fear and enhances memory of items encoded during extinction learning

Mental health and physical activity, Год журнала: 2023, Номер 24, С. 100510 - 100510

Опубликована: Фев. 11, 2023

Язык: Английский

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Adding physical activity to intensive trauma-focused treatment for post-traumatic stress disorder: results of a randomized controlled trial

Frontiers in Psychology, Год журнала: 2023, Номер 14

Опубликована: Июль 20, 2023

Introduction This randomized controlled trial examined the effectiveness of physical activity added to an intensive trauma-focused treatment (TFT) for post-traumatic stress disorder (PTSD) in comparison adding non-physical control activities. Methods A total 119 patients with PTSD were randomly assigned a condition (PA; n = 59) or (nPA; 60). The 8-day TFT programme consisted daily prolonged exposure, EMDR therapy, and psychoeducation, which was complemented activities versus mixtures guided (creative) tasks. As primary outcome, change clinician self-reported symptoms from pre-to post-treatment at 6 months follow-up measured. Results Intent-to-treat linear mixed-effects models showed no significant differences between PA nPA conditions on severity. Clinician significantly decreased both conditions, large effect sizes (e.g., CAPS-5 d pre-post 2.28). At post-treatment, 80.0% PA, 82.7% longer met diagnostic criteria PTSD. Regarding loss Complex diagnoses this 92.5% 95.0%, respectively. Conclusion Either additional activities, is very effective (Complex) PTSD, as reflected by status groups. Clinical registration Trialregister.nl Identifier: Trial NL9120.

Язык: Английский

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Mechanisms through which exercise reduces symptom severity and/or functional impairment in posttraumatic stress disorder (PTSD): Protocol for a living systematic review of human and non-human studies

Wellcome Open Research, Год журнала: 2025, Номер 8, С. 494 - 494

Опубликована: Апрель 14, 2025

Background Exercise can play an important role in reducing symptom severity and improving functional impairment patients with posttraumatic stress disorder (PTSD). However, the precise mechanisms underpinning effect of exercise PTSD management are not fully understood. This living systematic review aims to synthesize triangulate evidence from non-human human studies gain insight into biopsychosocial through which reduces impairment. Methods Independent searches will be conducted electronic databases identify eligible studies. Two reviewers independently conduct study selection, data extraction, risk bias assessment. We extract outcome variables that act as modifiers or mediators exercise. For studies, include equivalents clusters. primary severity. The secondary outcomes avoidance severity, reexperiencing hyperarousal negative cognitions mood impairment, loss diagnosis, dropout rates. To explain affects interest, we effects relate impact on potential mediating later outcomes. Comparison within-study direct indirect obtained mediation analysis, when reported, provide importance examined mediator. If appropriate, results using meta-analyses. examine total understand better symptoms function (when possible). about association between PTSD-related considered a consensus meeting sufficient is available. Protocol registration PROSPERO-ID: 453615

Язык: Английский

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High-intensity interval training in individuals with posttraumatic stress disorder: A randomized controlled pilot trial

Mental health and physical activity, Год журнала: 2024, Номер 26, С. 100579 - 100579

Опубликована: Фев. 5, 2024

Язык: Английский

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Mechanisms through which exercise reduces symptom severity and/or functional impairment in posttraumatic stress disorder (PTSD): Protocol for a living systematic review of human and non-human studies

Wellcome Open Research, Год журнала: 2023, Номер 8, С. 494 - 494

Опубликована: Окт. 25, 2023

Background Exercise can play an important role in reducing symptom severity and improving functional impairment patients with posttraumatic stress disorder (PTSD). However, the precise mechanisms underpinning effect of exercise PTSD management are not fully understood. This living systematic review aims to synthesize triangulate evidence from non-human human studies gain insight into biopsychosocial through which reduces impairment. Methods Independent searches will be conducted electronic databases identify eligible studies. Two reviewers independently conduct study selection, data extraction, risk bias assessment. We extract outcome variables that act as modifiers or mediators exercise. For studies, include equivalents clusters. primary severity. The secondary outcomes avoidance severity, reexperiencing hyperarousal negative cognitions mood impairment, loss diagnosis, dropout rates. To explain affects interest, we effects relate impact on potential mediating later outcomes. Comparison within-study direct indirect obtained mediation analysis, when reported, provide importance examined mediator. If appropriate, results using meta-analyses. examine total understand better symptoms function (when possible). about association between PTSD-related considered a consensus meeting sufficient is available. Protocol registration PROSPERO-ID: 453615

Язык: Английский

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Pharmacological manipulations of the dorsomedial and dorsolateral striatum during fear extinction have opposing effects on fear renewal

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Янв. 20, 2024

Abstract Systemic manipulations that enhance dopamine (DA) transmission around the time of fear extinction can strengthen and reduce conditioned relapse. Prior studies investigating brain regions where DA augments focus on targets mesolimbic mesocortical systems originating in ventral tegmental area, given role these neurons prediction error. The dorsal striatum (DS), a primary target nigrostriatal system substantia nigra (SN), is implicated behaviors beyond its canonical movement, such as reward punishment, goal-directed action, stimulus-response associations, but whether DS contributes to unknown. We have observed chemogenetic stimulation SN during prevents return contexts different from context, form relapse called renewal. This effect mimicked by D1 receptor (D1R) agonist injected into DS, thus implicating extinction. Different subregions subserve unique functions it unclear D1R acts Furthermore, although increases neural activity subregions, causally involved To explore extinction, adult, male Long-Evans rats received microinjections either SKF38393 or cocktail consisting GABA A /GABA B agonists muscimol/baclofen selectively dorsomedial (DMS) dorsolateral (DLS) immediately prior retention renewal were subsequently assessed drug-free. While increasing signaling DMS did not impact renewal, inactivation reduced later In contrast, DLS had no These data suggest opposing effects with promoting Mechanisms through which could influence contextual gating are discussed. Highlights Dorsolateral reduces Neural permits Dorsal roles Graphical

Язык: Английский

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Healthcare Practitioners’ Perceptions of the Barriers to Prescribing or Promoting Exercise in the Treatment of People with Mental Illness: A Scoping Review

Health & Social Care in the Community, Год журнала: 2024, Номер 2024, С. 1 - 20

Опубликована: Апрель 10, 2024

Contemporary healthcare for those experiencing mental illness requires practitioners (HCPs) to effectively incorporate the prescription of exercise in their treatment, accordance with clinical guidelines. However, there has been a lack effective implementation such recommendations. The purpose this review was identify barriers treatment people diagnosed as perceived by HCPs. APA PsycINFO, CINAHL, MEDLINE, and PubMed electronic databases were searched relevant articles published period from January 2005 September 2023. A total 18 papers included thematic synthesis. Four key themes identified across qualitative (8), quantitative (6), mixed method (4) papers, including knowledge confidence HCPs prescribing exercise; role responsibility; HCPs’ misconceptions client barriers; systemic issues impacting practices. or most common barrier. Some indicated desire develop skills prescription, while others preference an professional take responsibility aspect treatment. Systemic spread range issues, time, excessive workload, difficulties accessing qualified staff commonly cited. This provides further insight into faced makes recommendations regarding how address these order better implement guidelines thus improve quality provided illness.

Язык: Английский

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