Drug Advances in NAFLD: Individual and Combination Treatment Strategies of Natural Products and Small-Synthetic-Molecule Drugs

Biomolecules, Год журнала: 2025, Номер 15(1), С. 140 - 140

Опубликована: Янв. 17, 2025

Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic and is closely associated with metabolic diseases such as obesity, type 2 diabetes mellitus (T2DM), syndrome. However, effective treatment strategies for NAFLD are still lacking. In recent years, progress been made in understanding pathogenesis of NAFLD, identifying multiple therapeutic targets providing new directions drug development. This review summarizes advances focusing on mechanisms action natural products, small-synthetic-molecule drugs, combination therapy strategies. aims to provide insights treating NAFLD.

Язык: Английский

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State-of-the-art review of theabrownins: from preparation, structural characterization to health-promoting benefits

Critical Reviews in Food Science and Nutrition, Год журнала: 2023, Номер 64(31), С. 11321 - 11340

Опубликована: Авг. 16, 2023

As far as health benefit is concerned, dark tea one of the best beverages in world. Theabrownins are major ingredient contributing to benefits and known "the soft gold tea." A growing body evidence indicated that theabrownins macromolecular pigments with reddish-brown color mellow taste, mainly derived from oxidative polymerization polyphenols. main active ingredients which brings multiple health-promoting effects modulating lipid metabolism, reducing weight gain, attenuating diabetes, mitigating NAFLD, scavenging ROS, preventing tumors. More importantly, it's their substantial generation microbial fermentation endows much stronger hypolipidemic effect compared other types tea. This review firstly summarizes most recent findings on preparation, structural characteristics, theabrownins, emphasizing underlying molecular mechanism, especially different mechanisms behind theabrownins-mediated gut microbiota host's benefits. Furthermore, this points out limitations current research potential future directions, hoping provide updated scientific for better theoretical industrial utilization.

Язык: Английский

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Shenling Baizhu San ameliorates non-alcoholic fatty liver disease in mice by modulating gut microbiota and metabolites

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Апрель 24, 2024

The prevalence of non-alcoholic fatty liver disease (NAFLD) and its related mortality is increasing at an unprecedented rate. Traditional Chinese medicine (TCM) has been shown to offer potential for early prevention treatment NAFLD. new mechanism "Shenling Baizhu San" (SLBZS) examined in this study the NAFLD preclinical level.

Язык: Английский

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Theabrownin as a Potential Prebiotic Compound Regulates Lipid Metabolism via the Gut Microbiota, Microbiota-Derived Metabolites, and Hepatic FoxO/PPAR Signaling Pathways

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(15), С. 8506 - 8520

Опубликована: Апрель 3, 2024

The dysregulation of lipid metabolism poses a significant health threat, necessitating immediate dietary intervention. Our previous research unveiled the prebiotic-like properties theabrownin. This study aimed to further investigate theabrownin-gut microbiota interactions and their downstream effects on using integrated physiological, genomic, metabolomic, transcriptomic approaches. results demonstrated that theabrownin significantly ameliorated dyslipidemia, hepatic steatosis, systemic inflammation induced by high-fat/high-cholesterol diet (HFD). Moreover, improved HFD-induced gut dysbiosis alterations in microbiota-derived metabolites. Additionally, detailed interplay between was revealed. Analysis transcriptome indicated FoxO PPAR signaling pathways played pivotal roles response interactions, primarily through upregulating

Язык: Английский

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Formation, physicochemical properties, and biological activities of theabrownins

Food Chemistry, Год журнала: 2024, Номер 448, С. 139140 - 139140

Опубликована: Апрель 3, 2024

Язык: Английский

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Exploring the molecular mechanisms of tirzepatide in alleviating metabolic dysfunction-associated fatty liver in mice through integration of metabolomics, lipidomics, and proteomics

Lipids in Health and Disease, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 10, 2025

Clinical studies have suggested that tirzepatide may also possess hepatoprotective effects; however, the molecular mechanisms underlying this association remain unclear. In our study, we performed biochemical analyses of serum and histopathological examinations liver tissue in mice. To preliminarily explore on metabolic dysfunction-associated fatty disease (MAFLD), liquid chromatography-mass spectrometry (LC-MS) was employed for comprehensive metabolomic, lipidomic, proteomic MAFLD mice fed a high-fat diet (HFD). The results demonstrated significantly reduced levels alanine transaminase (ALT) aspartate (AST), as well hepatic triglycerides (TG) total cholesterol (TC), indicating its efficacy treating MAFLD. Further findings revealed acid uptake by downregulating Cd36 Fabp2/4, enhance mitochondrial-lysosomal function upregulating Lamp1/2. addition, promoted efflux reabsorption expression Hnf4a, Abcg5, Abcg8. These suggest exerts therapeutic effects reducing uptake, promoting excretion, enhancing function, providing theoretical basis understanding tirzepatide.

Язык: Английский

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Theabrownin from Dark Tea Ameliorates Insulin Resistance via Attenuating Oxidative Stress and Modulating IRS-1/PI3K/Akt Pathway in HepG2 Cells

Nutrients, Год журнала: 2023, Номер 15(18), С. 3862 - 3862

Опубликована: Сен. 5, 2023

Dark tea has great potential in regulating glycolipid metabolism, and theabrownin (TB) is considered to be the characteristic bioactive constituent of dark tea. This study evaluated ability TB1 (fermented for 7 days) TB2 14 isolated from reverse insulin resistance (IR) HepG2 cells. The results indicated that TB significantly ameliorated oxidative stress by improving mitochondrial function. In addition, improved glycogen synthesis glucose consumption, inhibited gluconeogenesis fatty acid synthesis, GSK3β (Glycogen synthase kinase 3β), G6Pase (Glucose-6-phosphatase), GCK (Glucokinase), PEPCK1 (Phosphoenolpyruvate carboxy 1), SREBP-1C (sterol regulatory element-binding protein 1C), FASN (fatty synthase), ACC (Acetyl-CoA carboxylase). Additionally, Western blot real-time PCR experiments demonstrated modulated glucolipid metabolism through IRS-1 (Insulin receptor substrate 1)/PI3K (phosphatidylinositol-3 kinase)/Akt (protein B) signaling pathway. Treatment with PI3K inhibitor a favorable correlation between activation action on metabolism. Notably, we observed had greater effect compared TB1, which, due its prolonged fermentation time, increased degree polymerization TB.

Язык: Английский

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Coffee, tea, and cocoa in obesity prevention: Mechanisms of action and future prospects

Current Research in Food Science, Год журнала: 2024, Номер 8, С. 100741 - 100741

Опубликована: Янв. 1, 2024

Obesity, a major public health problem, causes numerous complications that threaten human and increase the socioeconomic burden. The pathophysiology of obesity is primarily attributed to lipid metabolism disorders. Conventional anti-obesity medications have high abuse potential frequently deliver insufficient efficacy negative side-effects. Hence, functional foods are regarded as effective alternatives address obesity. Coffee, tea, cocoa, three widely consumed beverages, long been considered prevent obesity, several studies focused on their intrinsic molecular mechanisms in past few years. Therefore, this review, we discuss by which bioactive ingredients these beverages counteract from aspects adipogenesis, lipolysis, energy expenditure (thermogenesis). future prospects challenges for coffee, cocoa products treatment also discussed, can be pursued drug development prevention strategies against

Язык: Английский

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Recent Advances of Electrochemical and Optical Point-of-care Biosensors for Detecting Neurotransmitter Serotonin Biomarkers

Biosensors and Bioelectronics, Год журнала: 2024, Номер 267, С. 116743 - 116743

Опубликована: Сен. 6, 2024

Язык: Английский

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Heptamethoxyflavone Alleviates Metabolic Syndrome in High-Fat Diet-Fed Mice by Regulating the Composition, Function, and Metabolism of Gut Microbiota

Journal of Agricultural and Food Chemistry, Год журнала: 2023, Номер 71(26), С. 10050 - 10064

Опубликована: Июнь 22, 2023

3,5,6,7,8,3',4'-Heptamethoxyflavone (HMF) could prevent obesity and hyperlipidemia, but its effects on gut microbiota fecal metabolites remain unclear. Here, the effect of HMF metabolic syndrome (MS) was evaluated in high-fat diet (HFD)-fed mice, underlying mechanisms were revealed by integrative metagenomic metabolomic analyses. We demonstrated that effectively ameliorate HFD-induced MS alleviating body-weight gain, fat accumulation, hepatic steatosis, lipid glucose abnormalities. significantly altered composition HFD-fed mice with enrichment short-chain fatty acid (SCFA)- bile acid-producing beneficial bacteria inhibition harmful bacteria. Also, improved microbial functions up-regulating metabolism down-regulating inflammatory response-related pathways. Consistent changes, metabolite profile mainly characterized increasing SCFA several levels as well lowering lysophospholipids levels. Correlation analysis indicated three key species Faecalibaculum rodentium, Collinsella aerofaciens, Lactobacillus fermentum increase metabolites, i.e., SCFAs secondary acids, might play a positive role MS. Our results suggested alleviated possibly modulating composition, function, microbiota.

Язык: Английский

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