Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Ноя. 16, 2023
Abstract
Background
Ecological
imbalance
of
the
gut
microbiota
may
be
an
important
endogenous
trigger
mastitis,
but
underlying
mechanisms
are
unclear.
Recent
findings
indicated
that
selected
bacteria
maternal
gastrointestinal
can
reach
mammary
gland
through
entero-mammary
pathway.
In
addition,
metabolic
disturbances
one
most
prominent
ways
in
which
dysbiosis
promote
distal
organ
diseases.
Results
present
study,
we
found
Gastrointestinal-associated
mastitis
showed
significant
changes
levels,
among
succinate
was
significantly
increased.
treatment
exacerbates
endotoxemia-induced
mice.
Meanwhile,
induced
intestinal
ecological
dysregulation.
Further
experiments
demonstrated
increased
production
extracellular
vesicles
containing
microbial
(mEVs)
lipopolysaccharides,
could
diffuse
across
damaged
barrier
into
glands.
mEVs
promotes
inflammation
mainly
activation
TLR4/NF-κB
Conclusions
Our
suggest
proliferatio
enteric
pathogens
and
production,
suggesting
a
potential
strategy
for
intervention
based
on
regulation
pathogen
inhibition.
The
role
interspecific
communication
has
also
been
elucidated.
iScience,
Год журнала:
2024,
Номер
27(6), С. 110111 - 110111
Опубликована: Май 24, 2024
Osteophyte
formation,
a
key
indicator
of
osteoarthritis
(OA)
severity,
remains
poorly
understood
in
its
relation
to
gut
microbiota
and
metabolites
knee
(KOA).
We
conducted
16S
rDNA
sequencing
untargeted
metabolomics
on
fecal
serum
samples
from
20
healthy
volunteers,
80
KOA
patients
Guangdong,
100
Inner
Mongolia,
respectively.
Through
bioinformatics
analysis,
we
identified
3
genera
5
associated
with
osteophyte
formation.
Blautia
abundance
negatively
correlated
meat,
cheese,
bean
consumption.
The
dairy,
beef,
sugar,
salt
intake,
yet
positively
age
oil
Higher
levels
the
may
contribute
LTB4
PGD2
potentially
serving
as
biomarkers.
Mongolia
exhibited
lower
reduced
expression
metabolites,
possibly
due
cheese
consumption
habits,
resulting
less
Dairy
cow
mastitis
is
a
common
and
prevalent
disease
arose
by
various
complicated
pathogeny,
which
poses
serious
threat
to
the
health
of
cows,
safety
dairy
product
economic
benefits
for
pastures.
Due
high
stealthiness
long
incubation
period,
subclinical
(SM)
cows
causes
enormous
losses.
Besides
infection
exogenous
pathogenic
microorganisms,
previous
studies
demonstrated
that
gastrointestinal
microbial
dysbiosis
one
crucial
occurrence
development
based
on
theory
entero-mammary
axis.
Whereas,
limited
researches
have
been
conducted
potential
pathological
metabolic
mechanisms
underlying
relationship
between
gut
microbiota
SM
in
cows.
The
differences
blood
parameters,
microbiome,
plasma
fecal
metabolome
healthy
were
compared
performing
16
S
rDNA
sequencing
non-targeted
metabolomic
analysis
current
study.
content
total
cholesterol
(TC),
high-density
lipoprotein
(HDL-C),
activity
catalase
(CAT),
antioxidant
capacity(T-AOC)
significantly
decreased,
while
malondialdehyde
(MDA)
concentration
was
dramatically
increased
serum
comparison
with
harbored
more
abundant
Cyanobacteria,
Proteobacteria,
Succinivibrio
Lactobacillus_iners.
Moreover,
abundance
Paraprevotella,
Coprococcus,
Succiniclasticum,
Desulfovibrio
Bifidobacterium_pseudolongum
observably
reduced
Furthermore,
higher
pro-inflammatory
metabolites
observed
feces
(9(S)-HPODE,
25-hydroxycholesterol,
dodecanedioic
acid,
etc.)
(9-hydroxy-10,12-octadecadienoic
13,14-dihydro
PGF1α,
5,6-dehydro
arachidonic
myristic
histamine,
certain
anti-inflammatory
properties
(mandelic
gamma-tocotrienol,
deoxycholic
notably
decreased
or
SM.
intestinal
composition
profiles
distinct,
characterized
symbiotic
bacteria,
probiotics
anti-inflammatory,
compounds,
along
lipid
metabolites,
oxidative
stress
suffered
from
results
this
study
further
enriched
our
understanding
correlations
SM,
provided
insight
into
formulation
management
strategies
Veterinary Sciences,
Год журнала:
2025,
Номер
12(4), С. 370 - 370
Опубликована: Апрель 15, 2025
Piglets
weaned
per
sow
year
(PSY)
is
a
crucial
metric
for
assessing
the
reproductive
performances
of
sows
and
directly
affects
both
productivity
economic
profitability
pig
farms
[...]
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 25, 2024
The
modulation
of
intestinal
flora
by
various
polysaccharides
has
been
shown
to
mitigate
disease
progression.
Recent
research
reveals
a
significant
link
between
and
the
progression
mastitis.
This
study
demonstrates
that
oral
administration
