Important Factors Affecting Induction of Cell Death, Oxidative Stress and DNA Damage by Nano- and Microplastic Particles In Vitro

Cells, Год журнала: 2024, Номер 13(9), С. 768 - 768

Опубликована: Апрель 30, 2024

We have described the influence of selected factors that increase toxicity nanoplastics (NPs) and microplastics (MPs) with regard to cell viability, various types death, reactive oxygen species (ROS) induction, genotoxicity. These include plastic particle size (NPs/MPs), zeta potential, exposure time, concentration, functionalization, environmental type. Studies unequivocally shown smaller particles are more cytotoxic, penetrate cells easily, ROS formation, induce oxidative damage proteins, lipids, DNA. The toxic effects also concentration incubation time. NPs positive potential than those a negative because negatively charged, inducing stronger interactions. deleterious MPs increased by functionalization anionic or carboxyl groups, due greater interaction membrane components. Cationic NPs/MPs particularly their cellular uptake and/or on lysosomal membranes. polystyrene (PS) vary from one type another, normal sensitive cancerous ones. can be enhanced factors, including UV radiation, as they cause shrink change shape, which is important consideration when working environmentally-changed NPs/MPs. In summary, cytotoxicity, properties, genotoxicity depends duration action, Also, diameter exposed functionalized amino demonstrate higher larger, non-functionalized environmentally-unchanged potential.

Язык: Английский

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Polystyrene nanoplastics-induced lung apoptosis and ferroptosis via ROS-dependent endoplasmic reticulum stress

The Science of The Total Environment, Год журнала: 2023, Номер 912, С. 169260 - 169260

Опубликована: Дек. 10, 2023

Язык: Английский

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Ferritinophagy Mediated by Oxidative Stress-Driven Mitochondrial Damage Is Involved in the Polystyrene Nanoparticles-Induced Ferroptosis of Lung Injury

ACS Nano, Год журнала: 2023, Номер 17(24), С. 24988 - 25004

Опубликована: Дек. 12, 2023

Nanoplastics are a common type of contaminant in the air. However, no investigations have focused on toxic mechanism lung injury induced by nanoplastic exposure. In present study, polystyrene nanoplastics (PS-NPs) caused ferroptosis epithelial cells, which could be alleviated ferrostatin-1, deferoxamine, and N-acetylcysteine. Further investigation found that PS-NPs disturbed mitochondrial structure function triggered autophagy. Mechanistically, oxidative stress-derived damage contributed to ferroptosis, autophagy-dependent ferritinophagy was pivotal intermediate link, resulting ferritin degradation iron ion release. Furthermore, inhibition using ferrostatin-1 pulmonary systemic toxicity reverse mouse inhalation. Most importantly, lung-on-a-chip further used clarify role PS-NPs-induced visualizing stress, alveolar-capillary barrier dysfunction at organ level. summary, our study indicated an important for nanoplastics-induced through different inhalation models, three-dimensional-based lung-on-a-chip, providing insightful reference assessment nanoplastics.

Язык: Английский

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Synergistic effect of PS-MPs and Cd on male reproductive toxicity: Ferroptosis via Keap1-Nrf2 pathway

Journal of Hazardous Materials, Год журнала: 2023, Номер 461, С. 132584 - 132584

Опубликована: Сен. 20, 2023

Язык: Английский

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Mitochondria as a Target of Micro- and Nanoplastic Toxicity

Cambridge Prisms Plastics, Год журнала: 2024, Номер 2

Опубликована: Янв. 1, 2024

Abstract Mitochondria are unique organelles to perform critical functions such as energy production, lipid oxidation, calcium homeostasis, and steroid hormone synthesis in eukaryotic cells. The proper functioning of mitochondria is crucial for cellular survival, bioenergetics. Mitochondrial structure function maintained by the mitochondrial quality control system, which consists processes biogenesis, dynamics (fusion/fission), mitophagy, unfolded protein response UPR MT . dysfunction and/or damage associated with initiation progression several human diseases, including neurodegenerative, cardiovascular, age-related diabetes, cancer. Environmental stress contaminants may exacerbate sensitivity causes dysfunction. There growing evidence about impact nanoplastics (NPs) microplastics (MPs) on health function. MPs/NPs were reported trigger oxidative reactive oxygen species eventually change membrane potential. can cross through biological barriers body be internalized cells, potentially altering dynamics, bioenergetics, signaling pathways, thus impacting metabolism This review states effects homeostasis well apoptosis discussed.

Язык: Английский

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Acute exposure to polystyrene nanoparticles promotes liver injury by inducing mitochondrial ROS-dependent necroptosis and augmenting macrophage-hepatocyte crosstalk

Particle and Fibre Toxicology, Год журнала: 2024, Номер 21(1)

Опубликована: Апрель 12, 2024

Abstract Background The global use of plastic materials has undergone rapid expansion, resulting in the substantial generation degraded and synthetic microplastics nanoplastics (MNPs), which have potential to impose significant environmental burdens cause harmful effects on living organisms. Despite this, detrimental impacts MNPs exposure towards host cells tissues not been thoroughly characterized. Results In present study, we elucidated a previously unidentified hepatotoxic effect 20 nm polystyrene nanoparticles (PSNPs), rather than larger PS beads, by selectively inducing necroptosis macrophages. Mechanistically, PSNPs were rapidly internalized macrophages accumulated mitochondria, where they disrupted mitochondrial integrity, leading heightened production reactive oxygen species (mtROS). This elevated mtROS essentially triggered macrophages, enhanced crosstalk with hepatocytes, ultimately hepatocyte damage. Additionally, it was demonstrated that induced promoted acute liver injury mice. significantly mitigated administration inhibitor or systemic depletion prior injection. Conclusion Collectively, our study suggests profound toxicity PSNP triggering macrophage necroptosis, turn induces hepatotoxicity via intercellular between hepatocytes hepatic microenvironment.

Язык: Английский

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A review on advancements in atmospheric microplastics research: The pivotal role of machine learning

The Science of The Total Environment, Год журнала: 2024, Номер 945, С. 173966 - 173966

Опубликована: Июнь 17, 2024

Язык: Английский

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Realistic Nanoplastics Induced Pulmonary Damage via the Crosstalk of Ferritinophagy and Mitochondrial Dysfunction

ACS Nano, Год журнала: 2024, Номер 18(26), С. 16790 - 16807

Опубликована: Июнь 13, 2024

The smaller size fraction of plastics may be more substantially existing and detrimental than larger-sized particles. However, reports on nanoplastics (NPs), especially their airborne occurrences potential health hazards to the respiratory system, are scarce. Previous studies limit understanding real effects, since sphere-type polystyrene (PS) nanoparticles differ from NPs occurring in nature with respect physicochemical properties. Here, we employ a mechanical breakdown method, producing directly bulk plastic, preserving NP properties nature. We report that among four relatively high abundance materials PS, polyethylene terephthalate (PET), polyvinyl chloride (PVC), (PE) 100 nm, PVC induced slightly severe lung toxicity profiles compared other plastics. cytotoxicity is higher commercial PS comparable natural particles silicon dioxide (SiO2) anatase titanium (TiO2). Mechanistically, BH3-interacting domain death agonist (Bid) transactivation-mediated mitochondrial dysfunction nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy or ferroptosis likely common mechanisms regardless chemical composition. This study provides comprehensive data for evaluating risk atmospheric health.

Язык: Английский

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Systematic review of pulmonary toxicity induced by microplastics and nanoplastics: Insights from in vivo and in vitro studies

Annales de Toxicologie Analytique, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Multi-dimensional evaluation of cardiotoxicity in mice following respiratory exposure to polystyrene nanoplastics

Particle and Fibre Toxicology, Год журнала: 2023, Номер 20(1)

Опубликована: Ноя. 29, 2023

Nanoplastics (NPs) could be released into environment through the degradation of plastic products, and their content in air cannot ignored. To date, no studies have focused on cardiac injury effects underlying mechanisms induced by respiratory exposure to NPs.

Язык: Английский

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