Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 9, 2024
Neonatal
calf
diarrhea
(NCD)
remains
a
significant
contributor
to
mortality
within
the
first
3
weeks
of
life,
prompting
widespread
antibiotic
use
with
associated
concerns
about
antimicrobial
resistance
and
disruption
gut
microbiota.
Recent
research
exploring
NCD
treatments
targeting
microbiota
dysbiosis
has
highlighted
probiotic
supplementation
as
promising
safe
strategy
for
homeostasis.
However,
varying
treatment
outcomes
across
studies
suggest
need
efficient
options.
In
this
study,
we
evaluated
potential
probiotics
Limosilactobacillus
reuteri,
formally
known
Lactobacillus
isolated
from
healthy
neonatal
calves
treat
NCD.
Through
in
silico
whole
genome
analysis
vitro
assays,
identified
nine
L.
reuteri
strains,
which
were
then
administered
Calves
treated
strains
shed
feces
demonstrated
restored
normal
animal
behavior.
Leveraging
machine
learning
model,
profiles
bacterial
taxa
health
that
elevated
by
administration.
These
findings
represent
crucial
advancement
towards
sustainable
alternatives
managing
NCD,
contributing
significantly
global
efforts
mitigating
promoting
overall
welfare.
Microorganisms,
Год журнала:
2025,
Номер
13(2), С. 241 - 241
Опубликована: Янв. 23, 2025
The
gut
microbiota
has
emerged
as
a
critical
player
in
metabolic
and
liver
health,
with
its
influence
extending
to
the
pathogenesis
progression
of
steatotic
diseases.
This
review
delves
into
gut-liver
axis,
dynamic
communication
network
linking
microbiome
through
metabolic,
immunological,
inflammatory
pathways.
Dysbiosis,
characterized
by
altered
microbial
composition,
contributes
significantly
development
hepatic
steatosis,
inflammation,
fibrosis
via
mechanisms
such
barrier
dysfunction,
metabolite
production,
systemic
inflammation.
Dietary
patterns,
including
Mediterranean
diet,
are
highlighted
for
their
role
modulating
microbiota,
improving
axis
integrity,
attenuating
injury.
Additionally,
emerging
microbiota-based
interventions,
fecal
transplantation
bacteriophage
therapy,
show
promise
therapeutic
strategies
disease.
However,
challenges
population
heterogeneity,
methodological
variability,
knowledge
gaps
hinder
translational
application
current
findings.
Addressing
these
barriers
standardized
approaches
integrative
research
will
pave
way
microbiota-targeted
therapies
mitigate
global
burden
The Egyptian Journal of Internal Medicine,
Год журнала:
2024,
Номер
36(1)
Опубликована: Июль 25, 2024
Abstract
Background
The
gut
microbiota
(GM)
and
their
metabolites
have
garnered
significant
attention
for
roles
in
metabolic
syndrome
(MetS)
associated
conditions.
MetS,
characterized
by
a
cluster
of
abnormalities,
significantly
increases
the
risk
cardiovascular
disease
(CVD),
obesity,
insulin
resistance,
type
2
diabetes
mellitus
(T2DM).
dysbiosis
microbiota,
marked
changes
microbial
composition
function,
has
been
implicated
pathogenesis
MetS.
Main
body
This
review
synthesizes
recent
findings
elucidating
influence
GM
microbiota-derived
on
MetS
progression.
Notably,
alterations
dysregulation
such
as
short-chain
fatty
acids
(SCFAs),
trimethylamine
N-oxide
(TMAO),
polyamines,
amino
acids,
indole
derivatives
development.
These
play
crucial
processes,
imbalance
can
trigger
or
exacerbate
disturbances
with
Various
therapeutic
approaches,
including
dietary
interventions,
probiotics,
prebiotics,
precision
medicine
targeting
specific
metabolites,
offer
promising
strategies
managing
interventions
aim
to
restore
healthy
balance
regulate
production
beneficial
metabolites.
Conclusion
complexity
interactions
systemic
effects
necessitate
more
standardized
research
methodologies.
Future
investigations
focusing
personalized
non-invasive
diagnostic
tools
are
warranted
address
complexities
management.
Advancing
our
understanding
GM-metabolite-MetS
axis
will
be
developing
effective,
targeted
treatments
improving
patient
outcomes
Nutrients,
Год журнала:
2024,
Номер
16(22), С. 3830 - 3830
Опубликована: Ноя. 8, 2024
Aging
is
the
result
of
a
complex
interplay
physical,
environmental,
and
social
factors,
leading
to
an
increased
prevalence
chronic
age-related
diseases
that
burden
health
care
systems.
As
global
population
ages,
it
crucial
understand
aged
immune
system,
which
undergoes
declines
in
both
innate
adaptive
immunity.
This
decline
exacerbates
aging
process,
creating
feedback
loop
accelerates
onset
diseases,
including
infectious
autoimmune
disorders,
cancer.
Intervention
strategies,
dietary
adjustments,
pharmacological
treatments,
immunomodulatory
therapies,
represent
promising
approaches
counteract
immunosenescence.
These
interventions
aim
enhance
function
by
improving
activity
interactions
aging-affected
cells,
or
modulating
inflammatory
responses
through
suppression
excessive
cytokine
secretion
pathway
activation.
Such
strategies
have
potential
restore
homeostasis
mitigate
inflammation,
thus
reducing
risk
linked
aging.
In
summary,
this
review
provides
insights
into
effects
underlying
mechanisms
immunosenescence,
as
well
its
interventions,
with
particular
emphasis
on
relationship
between
aging,
immunity,
nutritional
factors.
Biomedicines,
Год журнала:
2024,
Номер
12(8), С. 1716 - 1716
Опубликована: Авг. 1, 2024
The
term
'inflammaging'
has
been
coined
to
describe
the
chronic
state
of
inflammation
derived
from
ongoing
cycles
tissue
damage
and
subsequent
immune
responses.
This
inflammatory
status
contributes
decline
organs
physiological
functions,
accelerates
aging
process,
increases
risk
age-related
illnesses
death.
During
aging,
gut
microbiota
(GM)
undergoes
significant
changes,
including
a
decreased
diversity
species,
in
beneficial
bacteria,
rise
proinflammatory
ones,
resulting
persistent
low-grade
inflammation.
Moreover,
environmental
factors,
such
as
diet
medications,
contribute
changes
GM
function,
preventing
or
promoting
inflammaging.
narrative
review
aims
clarify
underlying
mechanisms
inflammaging
specifically
investigate
influence
several
factors
on
these
mechanisms,
while
also
exploring
potential
differences
related
sex.
lifestyle
pharmacological
interventions
will
be
suggested
promote
healthy
aging.
