RSAD2: A pathogenic interferon-stimulated gene at the maternal-fetal interface of patients with systemic lupus erythematosus

Cell Reports Medicine, Год журнала: 2025, Номер unknown, С. 101974 - 101974

Опубликована: Фев. 1, 2025

Pregnancy disorders in patients with autoimmune diseases or viral infections are often associated an excessive response of type I interferons. We identify radical S-adenosyl methionine domain containing 2 (RSAD2) as a pathogenic interferon-stimulated gene (ISG) pregnancy complications systemic lupus erythematosus (SLE). The increased expression RSAD2 mainly occurs macrophages and structural cell populations at the maternal-fetal interface pregnant SLE. elevation leads to accumulation diacylglycerol lipids placenta, impairing necessary vascular development for fetus. Depletion Rsad2 mice models exposed interferon inducers significantly reduces lipid accumulation, injury, embryo disorders. An inhibitor, L-chicoric acid (LCA), alleviates damage, improving outcomes SLE-induced spontaneous mouse models. This study proposes potential targeting improve individuals heightened response.

Язык: Английский

---

Risk and protective factors of disease flare during pregnancy in systemic lupus erythematosus: a systematic review and meta-analysis

Clinical Rheumatology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

Язык: Английский

---

B cells: roles in physiology and pathology of pregnancy

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Окт. 7, 2024

B cells constitute a diverse and adaptable immune cell population with functions that can vary according to the environment circumstances. The involvement of in pregnancy, as well associated molecular pathways, has yet be investigated. This review consolidates current knowledge on activities regulation during particular focus roles various subsets effects cell-derived factors pregnancy outcomes. Moreover, examines significance cell-associated autoantibodies, cytokines, signaling pathways relation complications such loss, preeclampsia, preterm birth.

Язык: Английский

---

Effect of hydroxychloroquine on pregnancy outcome in patients with SLE: a systematic review and meta-analysis

Lupus Science & Medicine, Год журнала: 2024, Номер 11(2), С. e001239 - e001239

Опубликована: Окт. 1, 2024

Hydroxychloroquine (HCQ) is an antimalarial drug employed in the treatment of systemic lupus erythematosus (SLE). Prior studies reported inconsistent results regarding association between HCQ use during pregnancy and adverse outcomes. This study aimed to evaluate impact on pregnancy-related outcomes women with SLE.

Язык: Английский

---

2025 SWHR Women’s Health Research Agenda: Prioritizing Uterine Fibroids, Lupus, and Metabolism

Journal of Women s Health, Год журнала: 2025, Номер unknown

Опубликована: Янв. 29, 2025

Women face unique and multifaceted challenges throughout their lifespans, shaped by biological, societal, health care-related factors. These have led to gender disparities in disease burden, access care, representation medical research, underscoring the need increase targeted investments women's health. Historically, research on diseases that disproportionately affect women has been underfunded, hindering progress closing gaps. In March 2024, President of United States signed an Executive Order Women's Health Research Innovation, signaling a new commitment federal government prioritize address these disparities. The Society for (SWHR) consistently charge identify gaps advocate evidence-based initiatives improve well-being women. celebration its 35th anniversary, SWHR introduces 2025 Agenda, which outlines key priorities areas uterine health, autoimmune disease, cardiometabolic This agenda serves as strategic roadmap stakeholders engage with critical fostering collaboration accelerating unmet needs across lifespan.

Язык: Английский

---

Uncovering latent biological function associations through gene set embeddings

BMC Bioinformatics, Год журнала: 2025, Номер 26(1)

Опубликована: Март 24, 2025

Abstract Background The complexity of biological systems has increasingly been unraveled through computational methods, with network analysis now focusing on the construction and exploration well-defined interaction networks. Traditional graph-theoretical approaches have instrumental in mapping key processes using high-confidence data. However, these methods often struggle incomplete or/and heterogeneous datasets. In this study, we extend beyond conventional bipartite models by integrating attribute-driven knowledge from Molecular Signatures Database (MSigDB) node2vec algorithm. Results Our approach explores unsupervised relationships uncovers potential associations between genes terms connectivity analysis. By embedding both human mouse data into a shared vector space, validate our findings cross-species, further strengthening robustness method. Conclusions This integrative framework reveals expected novel insights, offering comprehensive perspective that complements traditional paves way for deeper understanding complex diseases.

Язык: Английский

---

Pregnancy outcomes and risk factors for thrombocytopenia in pregnant patients with systemic lupus erythematosus

BMC Pregnancy and Childbirth, Год журнала: 2025, Номер 25(1)

Опубликована: Март 25, 2025

To compare pregnancy outcomes between systemic lupus erythematosus (SLE) patients with thrombocytopenia and those without, to develop a nomogram for assessing the risk of developing SLE-related during pregnancy. Clinical data from 178 pregnant SLE were analyzed. Patients classified into normal platelet groups using count cutoff < 100 × 10^9/L. Pregnancy compared these groups. A was developed identify factors associated based on univariate multivariable logistic regression analyses. The performance assessed through receiver operating characteristic (ROC) curves, calibration decision curve analysis (DCA). Among patients, 34 in group 144 group. had significantly higher rate active disease (55.9% vs. 5.6%, P 0.001) SLE-Pregnancy Disease Activity Index (SLEPDAI) (4.71 ± 3.04 2.29 1.88, 0.001). When comparing (categorized by counts 50 10^9/L > 10^9/L) control group, incidence severe preeclampsia (20.00% 15.79% 4.86%, = 0.027) postpartum hemorrhage (26.32% 6.67% 3.47%, 0.007) also This exhibited elevated rates loss (73.33% 31.58% 4.17%, stillbirth 0.69%, Active disease, previous abortion, anti-β2GPI antibodies positivity identified as independent area under 0.833 (95% CI: 0.753–0.913). Both DCA indicated that model performed well. Thrombocytopenia is increased activity adverse outcomes, including stillbirth. may help clinicians improve management this patients. not applicable.

Язык: Английский

---

Bibliometric analysis of systemic lupus erythematosus during pregnancy from 2003 to 2024

Immunological Medicine, Год журнала: 2025, Номер unknown, С. 1 - 17

Опубликована: Март 28, 2025

Autoimmune diseases such as systemic lupus erythematosus (SLE) and antiphospholipid antibody syndrome have a significant impact on pregnancy, potentially exacerbating SLE symptoms leading to miscarriage, pre-eclampsia other pregnancy complications. To ensure the safety of patients during experts conducted in-depth research provided recommendations. Therefore, it is necessary provide thorough summary current status, hotspots emerging trends in this field. We systematically searched Web Science Core Collection database for studies from 1 January 2003 24 March 2024. then utilized CiteSpace generate knowledge visualization map. This analysis included total 2239 pregnancy. The yearly volume publications exhibits persistent increasing trend. United States had highest number was country, while Czech Republic centrality influence. focused three main areas: (1) outcomes autoimmune diseases, (2) newborn-related complications (3) medication management with Our study offers both visual scientific synopsis concerning furnishing valuable insights opening up new avenues researchers.

Язык: Английский

---

Challenges of anticoagulation in patients with systemic lupus erythematosus

Expert Opinion on Pharmacotherapy, Год журнала: 2025, Номер unknown

Опубликована: Апрель 20, 2025

Anticoagulation is frequently required for patients with systemic lupus erythematosus (SLE), given their high prevalence of cardiovascular disease and thrombosis, due to the complexity pathophysiology, some overlap antiphospholipid syndrome (APS), comorbidities, prevalent risk factors treatment complications. This article outlines epidemiology pathophysiology arterial and/or venous thrombosis in SLE, with/without APS. We discuss common comorbidities thrombotic disorders that may present as a complication SLE APS highlight recommendations current guidelines anticoagulation management, alongside relevant disease-specific considerations. specifically comment on use direct oral anticoagulants (DOACs) thromboembolism(VTE) these patients. Assessment aPL profile paramount While warfarin preferred high-risk patients, DOACs can be used selected group VTE no prior history thrombosis. Initiating setting Catastrophic (CAPS) extremely challenging. Knowledge gaps remain regarding management recurrent despite anticoagulation. Research needed optimize strategies reduce events

Язык: Английский

---

The causal effects of age at menarche, age at first live birth, and estradiol levels on systemic lupus erythematosus: A two-sample Mendelian randomization analysis

Lupus, Год журнала: 2023, Номер 32(8), С. 928 - 935

Опубликована: Май 29, 2023

To determine whether age at menarche (AAM), first live birth (AFB), and estradiol levels are causally correlated with the development of systemic lupus erythematosus (SLE).A two-sample Mendelian randomization (MR) analysis was performed after data collected from a dataset genome-wide association studies (GWASs) related to SLE (as outcome), open access databases find statistics AAM, AFB, exposure).In our study, negative causal correlation between AAM confirmed by MR (MR egger: beta = 0.116, SE 0.948, p 0.909; weighted median: -0.416, 0.192, 0.030; IVW: -0.395, 0.165, 0.016). However, there were no genetic effects AFB on SLE, based results as follows: - 2.815, 1.469, 0.065; Weighted 0.334, 0.378, 0.377; 0.188, 0.282, 0.505) 0.139, 0.294, 0.651; 0.063, 0.108, 0.559; 0.126, 0.097, 0.192).Our findings revealed that may be associated increased risk while such levels.

Язык: Английский

---