Journal of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
13(9), P. 2483 - 2483
Published: April 24, 2024
Systemic
autoimmune
rheumatic
diseases
(SARDs)
in
pregnancy
represent
a
complex
challenge
for
both
patients
and
healthcare
providers.
Timely
preparation
enables
adequate
disease
control,
thereby
reducing
the
risk
of
flare
complications.
Interdisciplinary
care
starting
from
pre-pregnancy
period
throughout
during
breastfeeding
ensures
better
fetal
maternal
outcomes.
This
review
provides
comprehensive
guide
to
counselling
SARDs,
an
overview
medication
management
strategies
tailored
pregnancy,
activity
monitoring
patients,
promotion
shared
decision
making
between
providers
patients.
Guidelines
international
organizations
were
selected
provide
basis
this
guidance
through
quintessential
discussion
points
care.
Cell Reports Medicine,
Journal Year:
2025,
Volume and Issue:
unknown, P. 101974 - 101974
Published: Feb. 1, 2025
Pregnancy
disorders
in
patients
with
autoimmune
diseases
or
viral
infections
are
often
associated
an
excessive
response
of
type
I
interferons.
We
identify
radical
S-adenosyl
methionine
domain
containing
2
(RSAD2)
as
a
pathogenic
interferon-stimulated
gene
(ISG)
pregnancy
complications
systemic
lupus
erythematosus
(SLE).
The
increased
expression
RSAD2
mainly
occurs
macrophages
and
structural
cell
populations
at
the
maternal-fetal
interface
pregnant
SLE.
elevation
leads
to
accumulation
diacylglycerol
lipids
placenta,
impairing
necessary
vascular
development
for
fetus.
Depletion
Rsad2
mice
models
exposed
interferon
inducers
significantly
reduces
lipid
accumulation,
injury,
embryo
disorders.
An
inhibitor,
L-chicoric
acid
(LCA),
alleviates
damage,
improving
outcomes
SLE-induced
spontaneous
mouse
models.
This
study
proposes
potential
targeting
improve
individuals
heightened
response.
Lupus Science & Medicine,
Journal Year:
2024,
Volume and Issue:
11(2), P. e001239 - e001239
Published: Oct. 1, 2024
Hydroxychloroquine
(HCQ)
is
an
antimalarial
drug
employed
in
the
treatment
of
systemic
lupus
erythematosus
(SLE).
Prior
studies
reported
inconsistent
results
regarding
association
between
HCQ
use
during
pregnancy
and
adverse
outcomes.
This
study
aimed
to
evaluate
impact
on
pregnancy-related
outcomes
women
with
SLE.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Oct. 7, 2024
B
cells
constitute
a
diverse
and
adaptable
immune
cell
population
with
functions
that
can
vary
according
to
the
environment
circumstances.
The
involvement
of
in
pregnancy,
as
well
associated
molecular
pathways,
has
yet
be
investigated.
This
review
consolidates
current
knowledge
on
activities
regulation
during
particular
focus
roles
various
subsets
effects
cell-derived
factors
pregnancy
outcomes.
Moreover,
examines
significance
cell-associated
autoantibodies,
cytokines,
signaling
pathways
relation
complications
such
loss,
preeclampsia,
preterm
birth.
Journal of Women s Health,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 29, 2025
Women
face
unique
and
multifaceted
challenges
throughout
their
lifespans,
shaped
by
biological,
societal,
health
care-related
factors.
These
have
led
to
gender
disparities
in
disease
burden,
access
care,
representation
medical
research,
underscoring
the
need
increase
targeted
investments
women's
health.
Historically,
research
on
diseases
that
disproportionately
affect
women
has
been
underfunded,
hindering
progress
closing
gaps.
In
March
2024,
President
of
United
States
signed
an
Executive
Order
Women's
Health
Research
Innovation,
signaling
a
new
commitment
federal
government
prioritize
address
these
disparities.
The
Society
for
(SWHR)
consistently
charge
identify
gaps
advocate
evidence-based
initiatives
improve
well-being
women.
celebration
its
35th
anniversary,
SWHR
introduces
2025
Agenda,
which
outlines
key
priorities
areas
uterine
health,
autoimmune
disease,
cardiometabolic
This
agenda
serves
as
strategic
roadmap
stakeholders
engage
with
critical
fostering
collaboration
accelerating
unmet
needs
across
lifespan.
BMC Bioinformatics,
Journal Year:
2025,
Volume and Issue:
26(1)
Published: March 24, 2025
Abstract
Background
The
complexity
of
biological
systems
has
increasingly
been
unraveled
through
computational
methods,
with
network
analysis
now
focusing
on
the
construction
and
exploration
well-defined
interaction
networks.
Traditional
graph-theoretical
approaches
have
instrumental
in
mapping
key
processes
using
high-confidence
data.
However,
these
methods
often
struggle
incomplete
or/and
heterogeneous
datasets.
In
this
study,
we
extend
beyond
conventional
bipartite
models
by
integrating
attribute-driven
knowledge
from
Molecular
Signatures
Database
(MSigDB)
node2vec
algorithm.
Results
Our
approach
explores
unsupervised
relationships
uncovers
potential
associations
between
genes
terms
connectivity
analysis.
By
embedding
both
human
mouse
data
into
a
shared
vector
space,
validate
our
findings
cross-species,
further
strengthening
robustness
method.
Conclusions
This
integrative
framework
reveals
expected
novel
insights,
offering
comprehensive
perspective
that
complements
traditional
paves
way
for
deeper
understanding
complex
diseases.
Expert Opinion on Pharmacotherapy,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 20, 2025
Anticoagulation
is
frequently
required
for
patients
with
systemic
lupus
erythematosus
(SLE),
given
their
high
prevalence
of
cardiovascular
disease
and
thrombosis,
due
to
the
complexity
pathophysiology,
some
overlap
antiphospholipid
syndrome
(APS),
comorbidities,
prevalent
risk
factors
treatment
complications.
This
article
outlines
epidemiology
pathophysiology
arterial
and/or
venous
thrombosis
in
SLE,
with/without
APS.
We
discuss
common
comorbidities
thrombotic
disorders
that
may
present
as
a
complication
SLE
APS
highlight
recommendations
current
guidelines
anticoagulation
management,
alongside
relevant
disease-specific
considerations.
specifically
comment
on
use
direct
oral
anticoagulants
(DOACs)
thromboembolism(VTE)
these
patients.
Assessment
aPL
profile
paramount
While
warfarin
preferred
high-risk
patients,
DOACs
can
be
used
selected
group
VTE
no
prior
history
thrombosis.
Initiating
setting
Catastrophic
(CAPS)
extremely
challenging.
Knowledge
gaps
remain
regarding
management
recurrent
despite
anticoagulation.
Research
needed
optimize
strategies
reduce
events
BMC Pregnancy and Childbirth,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: March 25, 2025
To
compare
pregnancy
outcomes
between
systemic
lupus
erythematosus
(SLE)
patients
with
thrombocytopenia
and
those
without,
to
develop
a
nomogram
for
assessing
the
risk
of
developing
SLE-related
during
pregnancy.
Clinical
data
from
178
pregnant
SLE
were
analyzed.
Patients
classified
into
normal
platelet
groups
using
count
cutoff
<
100
×
10^9/L.
Pregnancy
compared
these
groups.
A
was
developed
identify
factors
associated
based
on
univariate
multivariable
logistic
regression
analyses.
The
performance
assessed
through
receiver
operating
characteristic
(ROC)
curves,
calibration
decision
curve
analysis
(DCA).
Among
patients,
34
in
group
144
group.
had
significantly
higher
rate
active
disease
(55.9%
vs.
5.6%,
P
0.001)
SLE-Pregnancy
Disease
Activity
Index
(SLEPDAI)
(4.71
±
3.04
2.29
1.88,
0.001).
When
comparing
(categorized
by
counts
50
10^9/L
>
10^9/L)
control
group,
incidence
severe
preeclampsia
(20.00%
15.79%
4.86%,
=
0.027)
postpartum
hemorrhage
(26.32%
6.67%
3.47%,
0.007)
also
This
exhibited
elevated
rates
loss
(73.33%
31.58%
4.17%,
stillbirth
0.69%,
Active
disease,
previous
abortion,
anti-β2GPI
antibodies
positivity
identified
as
independent
area
under
0.833
(95%
CI:
0.753–0.913).
Both
DCA
indicated
that
model
performed
well.
Thrombocytopenia
is
increased
activity
adverse
outcomes,
including
stillbirth.
may
help
clinicians
improve
management
this
patients.
not
applicable.
Immunological Medicine,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 17
Published: March 28, 2025
Autoimmune
diseases
such
as
systemic
lupus
erythematosus
(SLE)
and
antiphospholipid
antibody
syndrome
have
a
significant
impact
on
pregnancy,
potentially
exacerbating
SLE
symptoms
leading
to
miscarriage,
pre-eclampsia
other
pregnancy
complications.
To
ensure
the
safety
of
patients
during
experts
conducted
in-depth
research
provided
recommendations.
Therefore,
it
is
necessary
provide
thorough
summary
current
status,
hotspots
emerging
trends
in
this
field.
We
systematically
searched
Web
Science
Core
Collection
database
for
studies
from
1
January
2003
24
March
2024.
then
utilized
CiteSpace
generate
knowledge
visualization
map.
This
analysis
included
total
2239
pregnancy.
The
yearly
volume
publications
exhibits
persistent
increasing
trend.
United
States
had
highest
number
was
country,
while
Czech
Republic
centrality
influence.
focused
three
main
areas:
(1)
outcomes
autoimmune
diseases,
(2)
newborn-related
complications
(3)
medication
management
with
Our
study
offers
both
visual
scientific
synopsis
concerning
furnishing
valuable
insights
opening
up
new
avenues
researchers.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(9), P. e30393 - e30393
Published: April 27, 2024
Hydroxychloroquine
(HCQ)
has
gained
significant
attention
as
a
therapeutic
option
for
systemic
lupus
erythematosus
(SLE)
because
of
its
multifaceted
mechanism
action.
It
is
lipophilic,
lysosomotropic
drug,
that
easily
traverses
cell
membranes
and
accumulates
in
lysosomes.
Once
accumulated,
HCQ
alkalizes
lysosomes
within
the
cytoplasm,
thereby
disrupting
their
function
interfering
with
processes
like
antigen
presentation.
Additionally,
shown
potential
modulating
T-cell
responses,
inhibiting
cytokine
production,
influencing
Toll-like
receptor
signaling.
Its
immunomodulatory
effects
have
generated
interest
application
autoimmune
disorders.
Despite
established
efficacy,
uncertainties
persist
regarding
optimal
concentrations
correlation
adverse
such
retinal
toxicity.
Therefore,
standardized
dosing
monitoring
guidelines
are
crucial.
In
this
study,
we
provide
comprehensive
review
mechanisms,
variations,
toxicity
profiles
HCQ,
which
essential
to
optimize
SLE
treatment
protocols
ensure
patient
safety.
