The FASEB Journal,
Год журнала:
2024,
Номер
38(20)
Опубликована: Окт. 24, 2024
LC3-associated
phagocytosis
(LAP)
is
a
distinct
type
of
autophagy
that
involves
the
sequestration
extracellular
material
by
phagocytes.
Beyond
removal
dead
cells
and
cellular
debris
from
eukaryotic
cells,
LAP
also
involved
in
variety
pathogens,
including
bacteria,
fungi,
viruses.
These
events
are
integral
to
multiple
physiological
pathological
processes,
such
as
host
defense,
inflammation,
tissue
homeostasis.
Dysregulation
has
been
associated
with
pathogenesis
several
human
diseases,
infectious
autoimmune
neurodegenerative
diseases.
Thus,
understanding
molecular
mechanisms
underlying
its
involvement
diseases
may
provide
new
insights
into
development
novel
therapeutic
strategies
for
these
conditions.
In
this
review,
we
summarize
highlight
current
consensus
on
role
biological
functions
disease
progression
propose
strategies.
Further
studies
needed
illustrate
precise
determine
targets
LAP-associated
pathologies.
Pathology & Oncology Research,
Год журнала:
2024,
Номер
30
Опубликована: Фев. 23, 2024
Geroscience,
a
burgeoning
discipline
at
the
intersection
of
aging
and
disease,
aims
to
unravel
intricate
relationship
between
process
pathogenesis
age-related
diseases.
This
paper
explores
pivotal
role
played
by
geroscience
in
reshaping
our
understanding
pathology,
with
particular
focus
on
These
diseases,
spanning
cardiovascular
cerebrovascular
disorders,
malignancies,
neurodegenerative
conditions,
significantly
contribute
morbidity
mortality
older
individuals.
We
delve
into
fundamental
cellular
molecular
mechanisms
underpinning
aging,
including
mitochondrial
dysfunction
senescence,
elucidate
their
profound
implications
for
various
Emphasis
is
placed
importance
assessing
key
biomarkers
biological
age
within
realm
pathology.
also
scrutinize
interplay
senescence
cancer
biology
as
central
area
focus,
underscoring
its
paramount
significance
contemporary
pathological
research.
Moreover,
we
shed
light
integration
anti-aging
interventions
that
target
processes,
such
senolytics,
mitochondria-targeted
treatments,
influence
epigenetic
regulation
domain
pathology
In
conclusion,
concepts
research
heralds
transformative
paradigm
shift
disease
promises
breakthroughs
prevention
treatment.
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Май 14, 2024
Interstitial
lung
disease
(ILD)
represents
a
significant
complication
of
rheumatoid
arthritis
(RA)
that
lacks
effective
treatment
options.
This
study
aimed
to
investigate
the
intrinsic
mechanism
by
which
resveratrol
attenuates
complicated
with
interstitial
through
AKT/TMEM175
pathway.
Abstract
Autophagy,
a
highly
conserved
cellular
self‐degradation
pathway,
has
emerged
with
novel
roles
in
the
realms
of
immunity
and
inflammation.
Genome‐wide
association
studies
have
unveiled
correlation
between
genetic
variations
autophagy‐related
genes
heightened
susceptibility
to
autoimmune
inflammatory
diseases.
Subsequently,
substantial
progress
been
made
unraveling
intricate
involvement
autophagy
inflammation
through
functional
studies.
The
pathway
plays
crucial
role
both
innate
adaptive
immunity,
encompassing
various
key
functions
such
as
pathogen
clearance,
antigen
processing
presentation,
cytokine
production,
lymphocyte
differentiation
survival.
Recent
research
identified
approaches
which
its
associated
proteins
modulate
immune
response,
including
noncanonical
autophagy.
This
review
provides
an
overview
latest
advancements
understanding
regulation
It
summarizes
associations
variants
range
diseases,
while
also
examining
utilizing
transgenic
animal
models
uncover
vivo
Furthermore,
delves
into
mechanisms
by
dysregulation
contributes
development
three
common
diseases
highlights
potential
for
autophagy‐targeted
therapies.
Cellular & Molecular Biology Letters,
Год журнала:
2024,
Номер
29(1)
Опубликована: Янв. 16, 2024
Abstract
Rheumatoid
arthritis
(RA)
is
an
autoimmune
disease
involving
T
and
B
lymphocytes.
Autoantibodies
contribute
to
joint
deterioration
worsening
symptoms.
Adenosine
deaminase
(ADA),
enzyme
in
purine
metabolism,
influences
adenosine
levels
inflammation.
Inhibiting
ADA
could
impact
RA
progression.
Intracellular
ATP
breakdown
generates
adenosine,
which
increases
hypoxic
inflammatory
conditions.
Lymphocytes
with
play
a
role
RA.
lymphocytic
activity
has
immune-regulatory
effect.
Synovial
fluid
of
are
closely
associated
the
disease’s
systemic
activity,
making
it
useful
parameter
for
evaluating
Flavonoids,
such
as
quercetin
(QUE),
natural
substances
that
can
inhibit
activity.
QUE
demonstrates
effects
restores
T-cell
homeostasis,
promising
candidate
therapy.
In
this
review,
we
will
explore
suppressing
reducing
produced
inflammation
RA,
including
preclinical
investigations
clinical
trials.
Graphical
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 16, 2024
Autophagy
is
a
cellular
process
that
functions
to
maintain
intracellular
homeostasis
via
the
degradation
and
recycling
of
defective
organelles
or
damaged
proteins.
This
dynamic
mechanism
participates
in
various
biological
processes,
such
as
regulation
differentiation,
proliferation,
survival,
modulation
inflammation
immune
responses.
Recent
evidence
has
demonstrated
involvement
polymorphisms
autophagy-related
genes
skin
autoimmune
diseases.
In
addition,
autophagy,
along
with
proteins,
also
contributes
maintenance
skin,
which
associated
disorders.
review
aims
provide
an
overview
multifaceted
role
autophagy
diseases
shed
light
on
potential
autophagy-targeting
therapeutic
strategies
dermatology.
Journal of Biochemical and Molecular Toxicology,
Год журнала:
2025,
Номер
39(1)
Опубликована: Янв. 1, 2025
ABSTRACT
The
eye
is
considered
to
be
an
immune‐privileged
region.
However,
several
parts
of
the
have
distinct
mechanisms
for
delivering
immune
cells
injury
sites
or
even
in
response
aging.
Although
these
responses
are
intended
protective,
visual
acuity
can
compromised
by
release
pro‐inflammatory
cytokines
cells,
which
induce
chronic
inflammation
and
fibrosis.
Age‐related
diseases
(AREDs)
primary
cause
vision
impairment
(VI)
elderly,
with
a
poor
comprehension
their
pathophysiology.
affect
both
anterior
posterior
segments,
resulting
diminished
quality
life
risk
irreversible
blindness.
Immune
system
dysregulation
upregulation
been
linked
AREDs,
underscoring
need
comprehend
inflammation's
impact
on
ocular
disorders
enhance
patient
symptom
management.
In
this
framework,
PubMed
database
was
searched
using
medical
subject
headings
(MeSH)
terms
“Age‐related
diseases,”
“dry
syndrome,”
“glaucoma,”
“cataract,”
“diabetic
retinopathy,”
“inflammation,”
“interleukin,”
“cytokine”
aim
overview
role
AREDs
discuss
potential
therapeutic
approaches.
Biology,
Год журнала:
2025,
Номер
14(1), С. 97 - 97
Опубликована: Янв. 18, 2025
Autophagy
is
a
vital
cellular
pathway
in
eukaryotic
cells,
including
neurons,
where
it
plays
significant
roles
neurodevelopment
and
maintenance.
A
crucial
step
autophagy
the
formation
of
class
III
phosphatidylinositol
3-kinase
complex
1
(PI3KC3-C1),
which
essential
for
initiating
autophagosome
biogenesis.
Beclin
key
component
PI3KC3-C1,
its
interactors
have
been
reported
to
affect
autophagy.
The
brain-enriched
adaptor
protein
FE65
has
shown
interact
with
Alzheimer’s
disease
amyloid
precursor
(APP)
alter
processing
APP.
Additionally,
implicated
various
pathways,
We
demonstrate
here
that
positively
regulates
FE65,
through
C-terminus,
1.
Notably,
overexpression
enhances
1-mediated
autophagy,
whereas
this
process
attenuated
knockout
cells.
Moreover,
stimulatory
effect
on
diminished
by
an
C-terminus
deletion
mutant
disrupts
FE65–Beclin
interaction.
Lastly,
we
found
FE65-Beclin
interaction
modulates
kinase
activity
PI3KC3-C1
complex.
Together,
identified
as
novel
interactor,
potentiates
PLoS ONE,
Год журнала:
2025,
Номер
20(1), С. e0318280 - e0318280
Опубликована: Янв. 27, 2025
Lupus
nephritis
(LN)
is
one
of
the
most
frequent
and
serious
organic
manifestations
systemic
lupus
erythematosus
(SLE).
Autophagy,
a
new
form
programmed
cell
death,
has
been
implicated
in
variety
renal
diseases,
but
relationship
between
autophagy
LN
remains
unelucidated.
We
analyzed
differentially
expressed
genes
(DEGs)
kidney
tissues
from
14
patients
7
normal
controls
using
GSE112943
dataset.
Key
modules
their
contained
were
identified
utilizing
weighted
gene
co-expression
network
analysis
(WGCNA).
Differentially
autophagy-related
(DE-ARGs)
among
DEGs,
key
module
(ARGs)
obtained
by
venn
plot,
subjected
to
protein-protein
interaction
construction.
Two
machine
learning
methods
applied
identify
signature
genes.
The
area
under
receiver
operating
characteristic
(ROC)
curves
was
used
assess
accuracy
also
immune
infiltration
LN.
Additionally,
association
diseases
predicted.
Finally,
expression
verified
clinical
samples
animal
experiments.
A
total
10304
DEGs
GSE1129943
29
WGCNA.
Among
them,
brown
coral
2
exhibited
significant
correlation
with
(cor
=
0.86,
-0.84,
p<0.001).
Machine
techniques
5
genes,
only
validated
external
dataset
GSE32591,
namely
MAP1LC3B
(AUC
0.920)
TNFSF10
0.937),
which
are
involved
apoptosis.
Immune
suggested
that
these
may
be
associated
In
addition,
have
linked
mice.
These
potential
provide
insights
into
molecular
diagnosis
treatment
