LC3‐associated phagocytosis and human diseases: Insights from mechanisms to therapeutic potential DOI
Xu Chen, Qi Su, Rui‐Ze Gong

et al.

The FASEB Journal, Journal Year: 2024, Volume and Issue: 38(20)

Published: Oct. 24, 2024

LC3-associated phagocytosis (LAP) is a distinct type of autophagy that involves the sequestration extracellular material by phagocytes. Beyond removal dead cells and cellular debris from eukaryotic cells, LAP also involved in variety pathogens, including bacteria, fungi, viruses. These events are integral to multiple physiological pathological processes, such as host defense, inflammation, tissue homeostasis. Dysregulation has been associated with pathogenesis several human diseases, infectious autoimmune neurodegenerative diseases. Thus, understanding molecular mechanisms underlying its involvement diseases may provide new insights into development novel therapeutic strategies for these conditions. In this review, we summarize highlight current consensus on role biological functions disease progression propose strategies. Further studies needed illustrate precise determine targets LAP-associated pathologies.

Language: Английский

Geroscience and pathology: a new frontier in understanding age-related diseases DOI Creative Commons
Mónika Fekete, Dávid Major,

Ágnes Fehér

et al.

Pathology & Oncology Research, Journal Year: 2024, Volume and Issue: 30

Published: Feb. 23, 2024

Geroscience, a burgeoning discipline at the intersection of aging and disease, aims to unravel intricate relationship between process pathogenesis age-related diseases. This paper explores pivotal role played by geroscience in reshaping our understanding pathology, with particular focus on These diseases, spanning cardiovascular cerebrovascular disorders, malignancies, neurodegenerative conditions, significantly contribute morbidity mortality older individuals. We delve into fundamental cellular molecular mechanisms underpinning aging, including mitochondrial dysfunction senescence, elucidate their profound implications for various Emphasis is placed importance assessing key biomarkers biological age within realm pathology. also scrutinize interplay senescence cancer biology as central area focus, underscoring its paramount significance contemporary pathological research. Moreover, we shed light integration anti-aging interventions that target processes, such senolytics, mitochondria-targeted treatments, influence epigenetic regulation domain pathology In conclusion, concepts research heralds transformative paradigm shift disease promises breakthroughs prevention treatment.

Language: Английский

Citations

29
Cadmium toxicity and autophagy: a review DOI

Yueting Shao,

Liting Zheng,

Yiguo Jiang

et al.

BioMetals, Journal Year: 2024, Volume and Issue: 37(3), P. 609 - 629

Published: Jan. 26, 2024

Language: Английский

Citations

13
PPARG-mediated autophagy activation alleviates inflammation in rheumatoid arthritis DOI

Qishun Geng,

Jiahe Xu,

Xiaoxue Cao

et al.

Journal of Autoimmunity, Journal Year: 2024, Volume and Issue: 146, P. 103214 - 103214

Published: April 21, 2024

Language: Английский

Citations

9
Resveratrol attenuates inflammation and fibrosis in rheumatoid arthritis-associated interstitial lung disease via the AKT/TMEM175 pathway DOI Creative Commons
Nannan Liu,

Xuefei Fan,

Yubao Shao

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: May 14, 2024

Interstitial lung disease (ILD) represents a significant complication of rheumatoid arthritis (RA) that lacks effective treatment options. This study aimed to investigate the intrinsic mechanism by which resveratrol attenuates complicated with interstitial through AKT/TMEM175 pathway.

Language: Английский

Citations

7
Modulation of the immunity and inflammation by autophagy DOI Creative Commons
Ting Gan,

Shu Qu,

Hong Zhang

et al.

MedComm, Journal Year: 2023, Volume and Issue: 4(4)

Published: July 2, 2023

Abstract Autophagy, a highly conserved cellular self‐degradation pathway, has emerged with novel roles in the realms of immunity and inflammation. Genome‐wide association studies have unveiled correlation between genetic variations autophagy‐related genes heightened susceptibility to autoimmune inflammatory diseases. Subsequently, substantial progress been made unraveling intricate involvement autophagy inflammation through functional studies. The pathway plays crucial role both innate adaptive immunity, encompassing various key functions such as pathogen clearance, antigen processing presentation, cytokine production, lymphocyte differentiation survival. Recent research identified approaches which its associated proteins modulate immune response, including noncanonical autophagy. This review provides an overview latest advancements understanding regulation It summarizes associations variants range diseases, while also examining utilizing transgenic animal models uncover vivo Furthermore, delves into mechanisms by dysregulation contributes development three common diseases highlights potential for autophagy‐targeted therapies.

Language: Английский

Citations

14
Mechanistic role of quercetin as inhibitor for adenosine deaminase enzyme in rheumatoid arthritis: systematic review DOI Creative Commons

Amira Atta,

Maha M. Salem, Karim Samy El-Said

et al.

Cellular & Molecular Biology Letters, Journal Year: 2024, Volume and Issue: 29(1)

Published: Jan. 16, 2024

Abstract Rheumatoid arthritis (RA) is an autoimmune disease involving T and B lymphocytes. Autoantibodies contribute to joint deterioration worsening symptoms. Adenosine deaminase (ADA), enzyme in purine metabolism, influences adenosine levels inflammation. Inhibiting ADA could impact RA progression. Intracellular ATP breakdown generates adenosine, which increases hypoxic inflammatory conditions. Lymphocytes with play a role RA. lymphocytic activity has immune-regulatory effect. Synovial fluid of are closely associated the disease’s systemic activity, making it useful parameter for evaluating Flavonoids, such as quercetin (QUE), natural substances that can inhibit activity. QUE demonstrates effects restores T-cell homeostasis, promising candidate therapy. In this review, we will explore suppressing reducing produced inflammation RA, including preclinical investigations clinical trials. Graphical

Language: Английский

Citations

5
The multifaceted role of autophagy in skin autoimmune disorders: a guardian or culprit? DOI Creative Commons
Yi Lin,

Xiuyi Wu,

Yiwen Yang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: April 16, 2024

Autophagy is a cellular process that functions to maintain intracellular homeostasis via the degradation and recycling of defective organelles or damaged proteins. This dynamic mechanism participates in various biological processes, such as regulation differentiation, proliferation, survival, modulation inflammation immune responses. Recent evidence has demonstrated involvement polymorphisms autophagy-related genes skin autoimmune diseases. In addition, autophagy, along with proteins, also contributes maintenance skin, which associated disorders. review aims provide an overview multifaceted role autophagy diseases shed light on potential autophagy-targeting therapeutic strategies dermatology.

Language: Английский

Citations

4
Lights and Shadows of Cytokines in Age‐Related Eye Diseases: A Narrative Literature Review DOI Open Access

Yuyu Xue,

Lu Ye,

Chan Huang

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2025, Volume and Issue: 39(1)

Published: Jan. 1, 2025

ABSTRACT The eye is considered to be an immune‐privileged region. However, several parts of the have distinct mechanisms for delivering immune cells injury sites or even in response aging. Although these responses are intended protective, visual acuity can compromised by release pro‐inflammatory cytokines cells, which induce chronic inflammation and fibrosis. Age‐related diseases (AREDs) primary cause vision impairment (VI) elderly, with a poor comprehension their pathophysiology. affect both anterior posterior segments, resulting diminished quality life risk irreversible blindness. Immune system dysregulation upregulation been linked AREDs, underscoring need comprehend inflammation's impact on ocular disorders enhance patient symptom management. In this framework, PubMed database was searched using medical subject headings (MeSH) terms “Age‐related diseases,” “dry syndrome,” “glaucoma,” “cataract,” “diabetic retinopathy,” “inflammation,” “interleukin,” “cytokine” aim overview role AREDs discuss potential therapeutic approaches.

Language: Английский

Citations

0
Beclin 1-Mediated Autophagy Is Potentiated by an Interaction with the Neuronal Adaptor FE65 DOI Creative Commons
Wai Wa Ray Chan, Jessica Chow, Dennis Dik‐Long Chau

et al.

Biology, Journal Year: 2025, Volume and Issue: 14(1), P. 97 - 97

Published: Jan. 18, 2025

Autophagy is a vital cellular pathway in eukaryotic cells, including neurons, where it plays significant roles neurodevelopment and maintenance. A crucial step autophagy the formation of class III phosphatidylinositol 3-kinase complex 1 (PI3KC3-C1), which essential for initiating autophagosome biogenesis. Beclin key component PI3KC3-C1, its interactors have been reported to affect autophagy. The brain-enriched adaptor protein FE65 has shown interact with Alzheimer’s disease amyloid precursor (APP) alter processing APP. Additionally, implicated various pathways, We demonstrate here that positively regulates FE65, through C-terminus, 1. Notably, overexpression enhances 1-mediated autophagy, whereas this process attenuated knockout cells. Moreover, stimulatory effect on diminished by an C-terminus deletion mutant disrupts FE65–Beclin interaction. Lastly, we found FE65-Beclin interaction modulates kinase activity PI3KC3-C1 complex. Together, identified as novel interactor, potentiates

Language: Английский

Citations

0
Identification and validation of key autophagy-related genes in lupus nephritis by bioinformatics and machine learning DOI Creative Commons
Su Zhang,

Weitao Hu,

Young Tang

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0318280 - e0318280

Published: Jan. 27, 2025

Lupus nephritis (LN) is one of the most frequent and serious organic manifestations systemic lupus erythematosus (SLE). Autophagy, a new form programmed cell death, has been implicated in variety renal diseases, but relationship between autophagy LN remains unelucidated. We analyzed differentially expressed genes (DEGs) kidney tissues from 14 patients 7 normal controls using GSE112943 dataset. Key modules their contained were identified utilizing weighted gene co-expression network analysis (WGCNA). Differentially autophagy-related (DE-ARGs) among DEGs, key module (ARGs) obtained by venn plot, subjected to protein-protein interaction construction. Two machine learning methods applied identify signature genes. The area under receiver operating characteristic (ROC) curves was used assess accuracy also immune infiltration LN. Additionally, association diseases predicted. Finally, expression verified clinical samples animal experiments. A total 10304 DEGs GSE1129943 29 WGCNA. Among them, brown coral 2 exhibited significant correlation with (cor = 0.86, -0.84, p<0.001). Machine techniques 5 genes, only validated external dataset GSE32591, namely MAP1LC3B (AUC 0.920) TNFSF10 0.937), which are involved apoptosis. Immune suggested that these may be associated In addition, have linked mice. These potential provide insights into molecular diagnosis treatment

Language: Английский

Citations

0