Microbiota and immune dynamics in rheumatoid arthritis: Mechanisms and therapeutic potential

Best Practice & Research Clinical Rheumatology, Год журнала: 2025, Номер unknown, С. 102035 - 102035

Опубликована: Янв. 1, 2025

Язык: Английский

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Current landscape of fecal microbiota transplantation in treating depression

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Июнь 25, 2024

Depression, projected to be the predominant contributor global disease burden, is a complex condition with diverse symptoms including mood disturbances and cognitive impairments. Traditional treatments such as medication psychotherapy often fall short, prompting pursuit of alternative interventions. Recent research has highlighted significant role gut microbiota in mental health, influencing emotional neural regulation. Fecal transplantation (FMT), infusion fecal matter from healthy donor into patient, emerges promising strategy ameliorate depressive by restoring microbial balance. The microbial-gut-brain (MGB) axis represents critical pathway through which potentially rectify dysbiosis modulate neuropsychiatric outcomes. Preclinical studies reveal that FMT can enhance neurochemicals reduce inflammatory markers, thereby alleviating behaviors. Moreover, shown promise clinical settings, improving gastrointestinal overall quality life patients depression. review highlights gut-brain depression need for further validate long-term safety efficacy FMT, identify specific therapeutic strains, develop targeted modulation strategies. Advancing our understanding could revolutionize treatment, shifting paradigm toward microbiome-targeting therapies.

Язык: Английский

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Gut microbiota and skin pathologies: Mechanism of the gut-skin axis in atopic dermatitis and psoriasis

International Immunopharmacology, Год журнала: 2024, Номер 141, С. 112658 - 112658

Опубликована: Авг. 12, 2024

Язык: Английский

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Harnessing CD8⁺ T cell dynamics in hepatitis B virus‐associated liver diseases: Insights, therapies and future directions

Clinical and Translational Medicine, Год журнала: 2024, Номер 14(7)

Опубликована: Июнь 27, 2024

Abstract Hepatitis B virus (HBV) infection playsa significant role in the etiology and progression of liver‐relatedpathologies, encompassing chronic hepatitis, fibrosis, cirrhosis, eventual hepatocellularcarcinoma (HCC). Notably, HBV stands as primary etiologicalfactor driving development HCC. Given contribution ofHBV to liver diseases, a comprehensive understanding immunedynamics microenvironment, spanning infection,fibrosis, HCC, is essential. In this review, we focused on thefunctional alterations CD8 + T cells within pathogenic livermicroenvironment from We thoroughly reviewed roles ofhypoxia, acidic pH, metabolic reprogramming, amino acid deficiency, inhibitory checkpointmolecules, immunosuppressive cytokines, gut‐liver communication shapingthe dysfunction microenvironment. Thesefactors significantly impact clinical prognosis. Furthermore, comprehensivelyreviewed cell‐based therapy strategies for diseases,encompassing infection, Strategies includeimmune checkpoint blockades, T‐cell targeting therapy, therapeuticT‐cell vaccination, adoptive transfer genetically engineered cells, along with combined usage programmed cell death protein‐1/programmeddeath ligand‐1 (PD‐1/PD‐L1) inhibitors mitochondria‐targeted antioxidants.Given that at various stages hepatitis Bvirus‐induced hepatocellular carcinoma (HBV HCC) shows promise, reviewedthe ongoing need research elucidate complex interplay between microenvironment toHCC. also discussed personalized treatment regimens, combining therapeuticstrategies harnessing gut microbiota modulation, which holds potential forenhanced benefits. conclusion, review delves into changes, during HCC progression, andrelated diseases.

Язык: Английский

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Staunch the Age Related Decline into Dementia, Cancer, Autoimmunity (Long Covid), Obesity, and Other Diseases with a Prebiotic, Probiotic, Postbiotic Triple Play

Qeios, Год журнала: 2024, Номер unknown

Опубликована: Апрель 9, 2024

“All diseases originate in the gut.” Hippocrates (400 BC) A healthy gut microbiome via gut-brain-axis elevates heart rate variability (HRV), a general measure of health and well-being. dysbiotic microbiome, low biodiversity butyrate producers, can alter tryptophan metabolism (ATM) increase kynurenine to ratio (KTR) with release proinflammatory cytokines, predominantly TNF-α, IL-6, IL-1β. These also characterize chronic inflammation, oxidative stress, multitude diseases. Also proposed is gut-lung dysbiosis concept consequent degradation ACE2 (richest lungs gut). Leaky (and lung) induced autoantibodies (AAs) related G-protein coupled receptors (GPCRs) combination increased Ang II further potentiate stress. The underappreciated pathogenic role these on invading Candida hyphae explored. efficacy fecal transplantation (FMT) treating dementia, cancer, autoimmunity supports plausibility success “FMT-lite”. This triple play prebiotic (d-mannose), probiotic (bifidobacteria lactobacilli), postbiotic (butyrate) might improve intestinal barrier integrity, oppose entry GPCR antigens (epitopes), suppress inflammatory cytokine triad, balance IFN-γ TGF-β, depress KTR, elevate HRV, extend lifespan its quality.

Язык: Английский

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Magnesium and Longevity

Опубликована: Ноя. 7, 2024

Magnesium (Mg) is not prominent among the list of well known anti-aging agents. Yet signs and symptoms aging mimic those Mg deficiency. required for over 800 enzymatic reactions (as 2022). This review does correlate status with clinical data on agents linked to longevity. The approach physiologic highlights specific dependent by these longevity biomarkers. Many share common pathways extend healthspan. a cofactor in synthesis vitamin D melatonin activation six eight B vitamins. It all CYP450 enzymes. directly responsible appropriate methylation proteins DNA, which control epigenome. MTHFR (methylenetetrahydrofolate reductase) 677T allele that compromises present majority Americans. Aberrant predicts severity Covid-19 its persistence into long Covid. silent benefactor may indirectly link agents, but only if viewed context calcium (Ca), i.e., Ca:Mg. Both compete same receptor. To fully exploit sufficient required. pertinent physiology presented.

Язык: Английский

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Intestinal Microbiota and Its Effect on Vaccine-Induced Immune Amplification and Tolerance

Vaccines, Год журнала: 2024, Номер 12(8), С. 868 - 868

Опубликована: Авг. 1, 2024

This review provides the potential of intestinal microbiota in vaccine design and application, exploring current insights into interplay between immune system, with a focus on its intermediary function efficacy. It summarizes families genera bacteria that are part may enhance or diminish efficacy discusses foundational principles sequence application gut microbial characteristics development. Future research should further investigate use multi-omics technologies to elucidate interactive mechanisms vaccine-induced responses, aiming optimize improve design.

Язык: Английский

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Molecular mimicry in the pathogenesis of autoimmune rheumatic diseases

Journal of Translational Autoimmunity, Год журнала: 2025, Номер 10, С. 100269 - 100269

Опубликована: Янв. 8, 2025

Autoimmune rheumatic diseases (ARDs) are a heterogeneous group of conditions characterized by excessive and misdirected immune responses against the body's own musculoskeletal tissues. Their exact aetiology remains unclear, with genetic, demographic, behavioural environmental factors implicated in disease onset. One prominent hypothesis for initial breach tolerance (leading to autoimmunity) is molecular mimicry, which describes structural or sequence similarities between human microbial proteins (mimotopes). This similarity can lead cross-reactive antibodies T-cell receptors, resulting an response autoantigens. Both commensal microbes microbiome pathogens trigger thereby potentially contributing onset ARDs. In this review, we focus on role mimicry rheumatoid arthritis systemic lupus erythematosus. Moreover, implications also briefly discussed ankylosing spondylitis, sclerosis myositis.

Язык: Английский

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Evidence from mendelian randomization identifies several causal relationships between primary membranous nephropathy and gut microbiota

Renal Failure, Год журнала: 2024, Номер 46(1)

Опубликована: Май 21, 2024

Research has showcased a correlation between disruptions in gut microbiota and primary membranous nephropathy (pMN), giving rise to the concept of 'gut-kidney axis'. However, precise relationship pMN remains elusive. Hence, this study endeavors investigate whether causal exists utilizing Mendelian randomization (MR) analysis.

Язык: Английский

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Fecal Microbiota Transplantation: Indications, Methods, and Challenges

The Journal of Microbiology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 18, 2024

Язык: Английский

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