Pediatrics Consilium Medicum,
Journal Year:
2024,
Volume and Issue:
2, P. 173 - 178
Published: Oct. 16, 2024
New
data
on
the
association
of
intestinal
microbiome
changes
with
some
serious
diseases
raised
question
role
bacteria
living
in
intestine
maintaining
human
health.
One
way
to
study
composition
and
function
adjust
it
is
fecal
microbiota
transplantation
(FMT),
which
refers
transfer
donor's
into
recipient's
body
modify
species
diversity.
Currently,
FMT
included
standards
care
for
relapsed
refractory
types
clostridial
infection
many
countries.
Its
possible
effect
course
such
as
inflammatory
bowel
disease,
irritable
syndrome,
metabolic
neurological
other
being
studied.
Fecal
biomaterial
storage
banks
have
been
established
Europe,
Asia,
USA
facilitate
donor
selection,
delivery
recipient
simplify
control
procedure,
safety
adverse
events.
In
Australia,
a
medicinal
product
approved,
includes
feces
specially
examined
prepared
donors.
Despite
unresolved
technological,
legal
ethical
issues,
has
already
promising
potential
treatment
diseases.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: June 25, 2024
Depression,
projected
to
be
the
predominant
contributor
global
disease
burden,
is
a
complex
condition
with
diverse
symptoms
including
mood
disturbances
and
cognitive
impairments.
Traditional
treatments
such
as
medication
psychotherapy
often
fall
short,
prompting
pursuit
of
alternative
interventions.
Recent
research
has
highlighted
significant
role
gut
microbiota
in
mental
health,
influencing
emotional
neural
regulation.
Fecal
transplantation
(FMT),
infusion
fecal
matter
from
healthy
donor
into
patient,
emerges
promising
strategy
ameliorate
depressive
by
restoring
microbial
balance.
The
microbial-gut-brain
(MGB)
axis
represents
critical
pathway
through
which
potentially
rectify
dysbiosis
modulate
neuropsychiatric
outcomes.
Preclinical
studies
reveal
that
FMT
can
enhance
neurochemicals
reduce
inflammatory
markers,
thereby
alleviating
behaviors.
Moreover,
shown
promise
clinical
settings,
improving
gastrointestinal
overall
quality
life
patients
depression.
review
highlights
gut-brain
depression
need
for
further
validate
long-term
safety
efficacy
FMT,
identify
specific
therapeutic
strains,
develop
targeted
modulation
strategies.
Advancing
our
understanding
could
revolutionize
treatment,
shifting
paradigm
toward
microbiome-targeting
therapies.
Clinical and Translational Medicine,
Journal Year:
2024,
Volume and Issue:
14(7)
Published: June 27, 2024
Abstract
Hepatitis
B
virus
(HBV)
infection
playsa
significant
role
in
the
etiology
and
progression
of
liver‐relatedpathologies,
encompassing
chronic
hepatitis,
fibrosis,
cirrhosis,
eventual
hepatocellularcarcinoma
(HCC).
Notably,
HBV
stands
as
primary
etiologicalfactor
driving
development
HCC.
Given
contribution
ofHBV
to
liver
diseases,
a
comprehensive
understanding
immunedynamics
microenvironment,
spanning
infection,fibrosis,
HCC,
is
essential.
In
this
review,
we
focused
on
thefunctional
alterations
CD8
+
T
cells
within
pathogenic
livermicroenvironment
from
We
thoroughly
reviewed
roles
ofhypoxia,
acidic
pH,
metabolic
reprogramming,
amino
acid
deficiency,
inhibitory
checkpointmolecules,
immunosuppressive
cytokines,
gut‐liver
communication
shapingthe
dysfunction
microenvironment.
Thesefactors
significantly
impact
clinical
prognosis.
Furthermore,
comprehensivelyreviewed
cell‐based
therapy
strategies
for
diseases,encompassing
infection,
Strategies
includeimmune
checkpoint
blockades,
T‐cell
targeting
therapy,
therapeuticT‐cell
vaccination,
adoptive
transfer
genetically
engineered
cells,
along
with
combined
usage
programmed
cell
death
protein‐1/programmeddeath
ligand‐1
(PD‐1/PD‐L1)
inhibitors
mitochondria‐targeted
antioxidants.Given
that
at
various
stages
hepatitis
Bvirus‐induced
hepatocellular
carcinoma
(HBV
HCC)
shows
promise,
reviewedthe
ongoing
need
research
elucidate
complex
interplay
between
microenvironment
toHCC.
also
discussed
personalized
treatment
regimens,
combining
therapeuticstrategies
harnessing
gut
microbiota
modulation,
which
holds
potential
forenhanced
benefits.
conclusion,
review
delves
into
changes,
during
HCC
progression,
andrelated
diseases.
Qeios,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 9, 2024
“All
diseases
originate
in
the
gut.”
Hippocrates
(400
BC)
A
healthy
gut
microbiome
via
gut-brain-axis
elevates
heart
rate
variability
(HRV),
a
general
measure
of
health
and
well-being.
dysbiotic
microbiome,
low
biodiversity
butyrate
producers,
can
alter
tryptophan
metabolism
(ATM)
increase
kynurenine
to
ratio
(KTR)
with
release
proinflammatory
cytokines,
predominantly
TNF-α,
IL-6,
IL-1β.
These
also
characterize
chronic
inflammation,
oxidative
stress,
multitude
diseases.
Also
proposed
is
gut-lung
dysbiosis
concept
consequent
degradation
ACE2
(richest
lungs
gut).
Leaky
(and
lung)
induced
autoantibodies
(AAs)
related
G-protein
coupled
receptors
(GPCRs)
combination
increased
Ang
II
further
potentiate
stress.
The
underappreciated
pathogenic
role
these
on
invading
Candida
hyphae
explored.
efficacy
fecal
transplantation
(FMT)
treating
dementia,
cancer,
autoimmunity
supports
plausibility
success
“FMT-lite”.
This
triple
play
prebiotic
(d-mannose),
probiotic
(bifidobacteria
lactobacilli),
postbiotic
(butyrate)
might
improve
intestinal
barrier
integrity,
oppose
entry
GPCR
antigens
(epitopes),
suppress
inflammatory
cytokine
triad,
balance
IFN-γ
TGF-β,
depress
KTR,
elevate
HRV,
extend
lifespan
its
quality.
Magnesium
(Mg)
is
not
prominent
among
the
list
of
well
known
anti-aging
agents.
Yet
signs
and
symptoms
aging
mimic
those
Mg
deficiency.
required
for
over
800
enzymatic
reactions
(as
2022).
This
review
does
correlate
status
with
clinical
data
on
agents
linked
to
longevity.
The
approach
physiologic
highlights
specific
dependent
by
these
longevity
biomarkers.
Many
share
common
pathways
extend
healthspan.
a
cofactor
in
synthesis
vitamin
D
melatonin
activation
six
eight
B
vitamins.
It
all
CYP450
enzymes.
directly
responsible
appropriate
methylation
proteins
DNA,
which
control
epigenome.
MTHFR
(methylenetetrahydrofolate
reductase)
677T
allele
that
compromises
present
majority
Americans.
Aberrant
predicts
severity
Covid-19
its
persistence
into
long
Covid.
silent
benefactor
may
indirectly
link
agents,
but
only
if
viewed
context
calcium
(Ca),
i.e.,
Ca:Mg.
Both
compete
same
receptor.
To
fully
exploit
sufficient
required.
pertinent
physiology
presented.
Journal of Translational Autoimmunity,
Journal Year:
2025,
Volume and Issue:
10, P. 100269 - 100269
Published: Jan. 8, 2025
Autoimmune
rheumatic
diseases
(ARDs)
are
a
heterogeneous
group
of
conditions
characterized
by
excessive
and
misdirected
immune
responses
against
the
body's
own
musculoskeletal
tissues.
Their
exact
aetiology
remains
unclear,
with
genetic,
demographic,
behavioural
environmental
factors
implicated
in
disease
onset.
One
prominent
hypothesis
for
initial
breach
tolerance
(leading
to
autoimmunity)
is
molecular
mimicry,
which
describes
structural
or
sequence
similarities
between
human
microbial
proteins
(mimotopes).
This
similarity
can
lead
cross-reactive
antibodies
T-cell
receptors,
resulting
an
response
autoantigens.
Both
commensal
microbes
microbiome
pathogens
trigger
thereby
potentially
contributing
onset
ARDs.
In
this
review,
we
focus
on
role
mimicry
rheumatoid
arthritis
systemic
lupus
erythematosus.
Moreover,
implications
also
briefly
discussed
ankylosing
spondylitis,
sclerosis
myositis.
Renal Failure,
Journal Year:
2024,
Volume and Issue:
46(1)
Published: May 21, 2024
Research
has
showcased
a
correlation
between
disruptions
in
gut
microbiota
and
primary
membranous
nephropathy
(pMN),
giving
rise
to
the
concept
of
'gut-kidney
axis'.
However,
precise
relationship
pMN
remains
elusive.
Hence,
this
study
endeavors
investigate
whether
causal
exists
utilizing
Mendelian
randomization
(MR)
analysis.
Vaccines,
Journal Year:
2024,
Volume and Issue:
12(8), P. 868 - 868
Published: Aug. 1, 2024
This
review
provides
the
potential
of
intestinal
microbiota
in
vaccine
design
and
application,
exploring
current
insights
into
interplay
between
immune
system,
with
a
focus
on
its
intermediary
function
efficacy.
It
summarizes
families
genera
bacteria
that
are
part
may
enhance
or
diminish
efficacy
discusses
foundational
principles
sequence
application
gut
microbial
characteristics
development.
Future
research
should
further
investigate
use
multi-omics
technologies
to
elucidate
interactive
mechanisms
vaccine-induced
responses,
aiming
optimize
improve
design.
